| 产品: | NECAB2 抗体 |
| 货号: | DF13179 |
| 描述: | Rabbit polyclonal antibody to NECAB2 |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse, Rat |
| 分子量: | 42 kDa; 43kD(Calculated). |
| 蛋白号: | Q7Z6G3 |
| RRID: | AB_2846139 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF13179, RRID:AB_2846139.
展开/折叠
EF hand calcium binding protein 2; EF-hand calcium-binding protein 2; N-terminal EF-hand calcium-binding protein 2; NECA2_HUMAN; Necab2; Neuronal calcium binding protein 2; Neuronal calcium-binding protein 2; Stip 2; Stip-2; Stip2; Synaptotagmin interacting protein 2; Synaptotagmin-interacting protein 2;
抗原和靶标
Expressed in brain. Expressed in the spinal dorsal horn with especially strong expression in lamina IIi; found in excitory synaptic boutons and in ependymal cells (at protein level).
- Q7Z6G3 NECA2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MCERAARLCRAGAHRLLREPPQQGRALGGLLRWVGARMGEPRESLAPAAPADPGPASPRGGTAVILDIFRRADKNDDGKLSLEEFQLFFADGVLNEKELEDLFHTIDSDNTNHVDTKELCDYFVDHMGDYEDVLASLETLNHSVLKAMGYTKKVYEGGSNVDQFVTRFLLKETANQIQSLLSSVESAVEAIEEQTSQLRQNHIKPSHSAAQTWCGSPTPASAPNHKLMAMEQGKTLPSATEDAKEEGLEAQISRLAELIGRLESKALWFDLQQRLSDEDGTNMHLQLVRQEMAVCPEQLSEFLDSLRQYLRGTTGVRNCFHITAVRLSDGFTFVIYEFWETEEAWKRHLQSPLCKAFRHVKVDTLSQPEALSRILVPAAWCTVGRD
研究背景
May act as a signaling scaffold protein that senses intracellular calcium. Can modulate ligand-induced internalization of ADORA2A and coupling efficiency of mGluR5/GRM5; for both receptors may regulate signaling activity such as promoting MAPK1/3 (ERK1/2) activation.
Cytoplasm. Cell projection>Dendrite. Cell projection>Axon. Cell membrane.
Note: Colocalizes with ADORA2A and/or mGluR5/GRM5 at the plasma membrane (PubMed:17689978, PubMed:19694902). Found in neuronal somata (PubMed:26843217). Detected in the cytoplasm of striatal neurons, at postsynaptic sites, filling dendritic shafts and spines, and at presynaptic sites, filling axon terminals (By similarity).
Expressed in brain. Expressed in the spinal dorsal horn with especially strong expression in lamina IIi; found in excitory synaptic boutons and in ependymal cells (at protein level).
Interacts (calcium-dependent) with ADORA2A and GRM5.
限制条款
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