MED10 Antibody - #DF13141

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产品: MED10 抗体
货号: DF13141
描述: Rabbit polyclonal antibody to MED10
应用: WB IHC IF/ICC
文献验证: WB, IHC
反应: Human, Mouse, Rat
预测: Pig, Zebrafish, Bovine, Sheep, Dog, Chicken, Xenopus
蛋白号: Q9BTT4
RRID: AB_2846101

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   规格 价格 库存
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IF/ICC 1:100-1:500, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
MED10 Antibody detects endogenous levels of total MED10.
RRID:
AB_2846101
引用格式: Affinity Biosciences Cat# DF13141, RRID:AB_2846101.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

L6; med10; MED10_HUMAN; Mediator complex subunit 10; Mediator of RNA polymerase II transcription subunit 10; Mediator of RNA polymerase II transcription, subunit 10 homolog; NUT2; Transformation-related gene 17 protein; Transformation-related gene 20 protein; Transformation-related protein 17; Transformation-related protein 20; TRG-17; TRG-20; TRG17; TRG20;

抗原和靶标

免疫原:

A synthesized peptide derived from human MED10, corresponding to a region within the internal amino acids.

基因/基因ID:
MED10(84246)

文献引用

1). MED10 as a Novel Oncogenic Driver in HCC: Promoting Cell Cycle Progression and Proliferation Through RAF1 Activation. Frontiers in bioscience (Landmark edition), 2025 (PubMed: 40917057) [IF=3.3]

Application: WB    Species: human    Sample:

Fig. 1. MED10 overexpression in HCC correlates with poor prognosis. (A) Expression levels of MED10 across pan-cancer. The red box indicates higher expression of MED10 in liver hepatocellular carcinoma (LIHC) compared to adjacent normal tissues. (B,C) Elevated MED10 in HCC versus adjacent normal liver tissues. (D) Diagnostic receiver operating characteristic (ROC) curve for MED10 in HCC (area under the curve (AUC) = 0.897). (E–G) Survival analyses showing reduced overall survival (OS), disease-specific survival (DSS), and progression-free interval (PFI) in high-MED10 expressors. (H,I) Univariate and multivariate Cox regressions identifying MED10 as independent prognostic factor. (J) Prognostic nomogram predicting 1-/3-/5-year OS. (K) Nomogram calibration curves. (L) Representative Immunohistochemistry (IHC) of MED10 in HCC and normal tissues. Scale bars: 200 μm (top) and 50 μm (bottom). (M) Quantitative IHC scoring in 41 paired samples. (N) Western blotting confirmation of MED10 overexpression.

Application: IHC    Species: human    Sample:

Fig. 1. MED10 overexpression in HCC correlates with poor prognosis. (A) Expression levels of MED10 across pan-cancer. The red box indicates higher expression of MED10 in liver hepatocellular carcinoma (LIHC) compared to adjacent normal tissues. (B,C) Elevated MED10 in HCC versus adjacent normal liver tissues. (D) Diagnostic receiver operating characteristic (ROC) curve for MED10 in HCC (area under the curve (AUC) = 0.897). (E–G) Survival analyses showing reduced overall survival (OS), disease-specific survival (DSS), and progression-free interval (PFI) in high-MED10 expressors. (H,I) Univariate and multivariate Cox regressions identifying MED10 as independent prognostic factor. (J) Prognostic nomogram predicting 1-/3-/5-year OS. (K) Nomogram calibration curves. (L) Representative Immunohistochemistry (IHC) of MED10 in HCC and normal tissues. Scale bars: 200 μm (top) and 50 μm (bottom). (M) Quantitative IHC scoring in 41 paired samples. (N) Western blotting confirmation of MED10 overexpression.

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