Phospho-CDC37 (Ser13) Antibody - #AF3458

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产品: 磷酸化 CDC37 (Ser13) 抗体
货号: AF3458
描述: Rabbit polyclonal antibody to Phospho-CDC37 (Ser13)
应用: WB IHC IF/ICC
反应: Human, Mouse, Rat
预测: Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
分子量: 44kDa; 44kD(Calculated).
蛋白号: Q16543
RRID: AB_2834896

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MSDS
说明书
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实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
预测:
Zebrafish(100%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%), Chicken(100%), Xenopus(100%)
克隆:
Polyclonal
特异性:
Phospho-CDC37 (Ser13) Antibody detects endogenous levels of CDC37 only when phosphorylated at Serine 13.
RRID:
AB_2834896
引用格式: Affinity Biosciences Cat# AF3458, RRID:AB_2834896.
偶联:
Unconjugated.
纯化:
The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

CDC 37; Cdc37; CDC37 cell division cycle 37 homolog; CDC37 cell division cycle 37 S cerevisiae homolog; CDC37 cell division cycle 37, S cerevisiae, homolog of; Cdc37 homolog; CDC37 protein; CDC37_HUMAN; CDC37A; cell division cycle 37; Cell division cycle 37 homolog; Hsp90 chaperone protein kinase targeting subunit; Hsp90 chaperone protein kinase targeting subunit p50Cdc37; Hsp90 chaperone protein kinase-targeting subunit; Hsp90 co chaperone Cdc37; Hsp90 co-chaperone Cdc37; p50; p50Cdc37; S cerevisiae hypothetical protein CDC37;

抗原和靶标

免疫原:
Uniprot:

Q16543(CDC37_HUMAN) >>Visit HPA database.

基因/基因ID:
CDC37(11140)
描述:
The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction.
序列:
MVDYSVWDHIEVSDDEDETHPNIDTASLFRWRHQARVERMEQFQKEKEELDRGCRECKRKVAECQRKLKELEVAEGGKAELERLQAEAQQLRKEERSWEQKLEEMRKKEKSMPWNVDTLSKDGFSKSMVNTKPEKTEEDSEEVREQKHKTFVEKYEKQIKHFGMLRRWDDSQKYLSDNVHLVCEETANYLVIWCIDLEVEEKCALMEQVAHQTIVMQFILELAKSLKVDPRACFRQFFTKIKTADRQYMEGFNDELEAFKERVRGRAKLRIEKAMKEYEEEERKKRLGPGGLDPVEVYESLPEELQKCFDVKDVQMLQDAISKMDPTDAKYHMQRCIDSGLWVPNSKASEAKEGEEAGPGDPLLEAVPKTGDEKDVSV

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Horse
100
Bovine
100
Sheep
100
Dog
100
Xenopus
100
Zebrafish
100
Chicken
100
Rabbit
100
Pig
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - Q16543 作为底物

Site PTM Type Enzyme
M1 Acetylation
V2 Acetylation
Y4 Phosphorylation
S5 Phosphorylation
S13 Phosphorylation P19784 (CSNK2A2) , P68400 (CSNK2A1)
K45 Acetylation
K67 Ubiquitination
K69 Acetylation
K69 Ubiquitination
K78 Acetylation
K93 Ubiquitination
S97 Phosphorylation
K101 Ubiquitination
K110 Ubiquitination
S111 Phosphorylation
T118 Phosphorylation
S120 Phosphorylation
K121 Ubiquitination
K126 Ubiquitination
S127 Phosphorylation
T131 Phosphorylation
K132 Sumoylation
K135 Ubiquitination
T136 Phosphorylation
S140 Phosphorylation
K154 Acetylation
K157 Acetylation
K240 Acetylation
R246 Methylation
K260 Ubiquitination
Y278 Phosphorylation
Y298 Phosphorylation P07947 (YES1)
S300 Phosphorylation
K307 Ubiquitination
C308 S-Nitrosylation
K312 Ubiquitination
S322 Phosphorylation
K323 Ubiquitination
K330 Acetylation
K330 Ubiquitination
C336 S-Nitrosylation
S339 Phosphorylation
S346 Phosphorylation
K347 Ubiquitination
K352 Ubiquitination
K369 Ubiquitination
T370 Phosphorylation
K374 Ubiquitination
S377 Phosphorylation

研究背景

功能:

Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. Inhibits HSP90AA1 ATPase activity.

翻译修饰:

Constitutively sumoylated by UBE2I.

细胞定位:

Cytoplasm.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
亚基结构:

Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones STIP1/HOP, CDC37, PPP5C, PTGES3/p23, TSC1 and client protein TSC2. Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones CDC37, PPP5C, TSC1 and client protein TSC2, CDK4, AKT, RAF1 and NR3C1; this complex does not contain co-chaperones STIP1/HOP and PTGES3/p23. Forms a complex with Hsp90/HSP90AB1 and CDK6. Interacts with HSP90AA1. Interacts with AR, CDK4, CDK6 and EIF2AK1. Interacts with RB1 (By similarity). Interacts with KSR1. Interacts with FLCN, FNIP1 and FNIP2.

蛋白家族:

Belongs to the CDC37 family.

研究领域

· Environmental Information Processing > Signal transduction > PI3K-Akt signaling pathway.   (View pathway)

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