EHBP1 Antibody - #DF12971

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产品: EHBP1 抗体
货号: DF12971
描述: Rabbit polyclonal antibody to EHBP1
应用: WB IHC
反应: Human, Mouse, Rat
预测: Horse, Rabbit, Dog
分子量: 140 kDa; 140kD(Calculated).
蛋白号: Q8NDI1
RRID: AB_2845932

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   规格 价格 库存
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MS Report
HPLC Report
MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
IHC 1:50-1:200, WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
预测:
Horse(100%), Rabbit(%), Dog(%)
克隆:
Polyclonal
特异性:
EHBP1 Antibody detects endogenous levels of total EHBP1.
RRID:
AB_2845932
引用格式: Affinity Biosciences Cat# DF12971, RRID:AB_2845932.
偶联:
Unconjugated. 130
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

EH domain binding protein 1; NACSIN;

抗原和靶标

免疫原:
Uniprot:

Q8NDI1(EHBP1_HUMAN) >>Visit HPA database.

基因/基因ID:
EHBP1(23301)
序列:
MASVWKRLQRVGKHASKFQFVASYQELMVECTKKWQPDKLVVVWTRRSRRKSSKAHSWQPGIKNPYRGVVVWPVPENIEITVTLFKDPHAEEFEDKEWTFVIENESPSGRRKALATSSINMKQYASPMPTQTDVKLKFKPLSKKVVSAALQFSLSCIFLREGKATDEDMQSLASLMSMKQADIGNLDDFEEDNEDDDENRVNQEEKAAKITEIVNQLNALSSLDEDQDDCIKQANMRSAKSASSSEELINKLNFLDEAEKDLATVNSNPFDDPDAAELNPFGDPDSEEPITETASPRKTEDSFYNNSYNPFKEVQTPQYLNPFDEPEAFVTIKDSPPQSTKRKNIRPVDMSKYLYADSSKTEEEELDESNPFYEPKSTPPPNNLVNPVQELETERRVKRKAPAPPVLSPKTGVLNENTVSAGKDLSTSPKPSPIPSPVLGRKPNASQSLLVWCKEVTKNYRGVKITNFTTSWRNGLSFCAILHHFRPDLIDYKSLNPQDIKENNKKAYDGFASIGISRLLEPSDMVLLAIPDKLTVMTYLYQIRAHFSGQELNVVQIEENSSKSTYKVGNYETDTNSSVDQEKFYAELSDLKREPELQQPISGAVDFLSQDDSVFVNDSGVGESESEHQTPDDHLSPSTASPYCRRTKSDTEPQKSQQSSGRTSGSDDPGICSNTDSTQAQVLLGKKRLLKAETLELSDLYVSDKKKDMSPPFICEETDEQKLQTLDIGSNLEKEKLENSRSLECRSDPESPIKKTSLSPTSKLGYSYSRDLDLAKKKHASLRQTESDPDADRTTLNHADHSSKIVQHRLLSRQEELKERARVLLEQARRDAALKAGNKHNTNTATPFCNRQLSDQQDEERRRQLRERARQLIAEARSGVKMSELPSYGEMAAEKLKERSKASGDENDNIEIDTNEEIPEGFVVGGGDELTNLENDLDTPEQNSKLVDLKLKKLLEVQPQVANSPSSAAQKAVTESSEQDMKSGTEDLRTERLQKTTERFRNPVVFSKDSTVRKTQLQSFSQYIENRPEMKRQRSIQEDTKKGNEEKAAITETQRKPSEDEVLNKGFKDTSQYVVGELAALENEQKQIDTRAALVEKRLRYLMDTGRNTEEEEAMMQEWFMLVNKKNALIRRMNQLSLLEKEHDLERRYELLNRELRAMLAIEDWQKTEAQKRREQLLLDELVALVNKRDALVRDLDAQEKQAEEEDEHLERTLEQNKGKMAKKEEKCVLQ

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Horse
100
Dog
100
Rabbit
100
Bovine
75
Pig
56
Sheep
56
Xenopus
56
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - Q8NDI1 作为底物

Site PTM Type Enzyme
K33 Acetylation
K34 Acetylation
S106 Phosphorylation
K163 Ubiquitination
T165 Phosphorylation
S171 Phosphorylation
S174 Phosphorylation
S177 Phosphorylation
K206 Ubiquitination
T291 Phosphorylation
T293 Phosphorylation
T299 Phosphorylation
S302 Phosphorylation
Y304 Phosphorylation
S307 Phosphorylation
Y319 Phosphorylation
T331 Phosphorylation
S335 Phosphorylation
Y355 Phosphorylation
S358 Phosphorylation
S369 Phosphorylation
T378 Phosphorylation
S408 Phosphorylation
S420 Phosphorylation
S426 Phosphorylation
T427 Phosphorylation
S428 Phosphorylation
S432 Phosphorylation
S436 Phosphorylation
S577 Phosphorylation
S578 Phosphorylation
Y585 Phosphorylation
S589 Phosphorylation
K592 Ubiquitination
T647 Phosphorylation
S649 Phosphorylation
T663 Phosphorylation
S666 Phosphorylation
T694 Phosphorylation
S698 Phosphorylation
Y701 Phosphorylation
S710 Phosphorylation
T718 Phosphorylation
S730 Phosphorylation
S742 Phosphorylation
S747 Phosphorylation
S751 Phosphorylation
T756 Phosphorylation
S759 Phosphorylation
K763 Ubiquitination
Y766 Phosphorylation
S767 Phosphorylation
Y768 Phosphorylation
S769 Phosphorylation
S781 Phosphorylation
S787 Phosphorylation
S812 Phosphorylation
T846 Phosphorylation
S854 Phosphorylation
S887 Phosphorylation
Y888 Phosphorylation
S964 Phosphorylation
S967 Phosphorylation
T974 Phosphorylation
S976 Phosphorylation
S977 Phosphorylation
T1011 Phosphorylation
S1019 Phosphorylation
Y1023 Phosphorylation
S1035 Phosphorylation
T1040 Phosphorylation
T1053 Phosphorylation
S1058 Phosphorylation
T1070 Phosphorylation
K1097 Ubiquitination
Y1101 Phosphorylation
K1188 Ubiquitination

研究背景

功能:

May play a role in actin reorganization. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking. Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity).

翻译修饰:

Prenylated (Probable). Farnelysation (predominant) and geranylgeranylation has been observed in vitro.

细胞定位:

Cytoplasm. Membrane. Endosome.
Note: Mostly found in cytosol and plasma membrane.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
亚基结构:

Interacts with EHD1 (By similarity). Interacts with EHD2. Interacts with RAB8A, RAB10, RAB13 and RAB15 (in their GTP-bound forms); at least in case of RAB8A may bind 2 molecules of RAB8A simultaneously through a high and a low affinity binding site, respectively.

蛋白家族:

The CAAX motif is a signal for prenylation and required for endosomal colocalization with Rab8 and Rab10.

The bivalent Mical/EHBP Rab binding (bMERB) domain, mediates binding to Rab8, Rab10, Rab10, Rab13 and Rab15 (in their GTP-bound forms).

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