| 产品: | DDRGK1 抗体 |
| 货号: | DF12933 |
| 描述: | Rabbit polyclonal antibody to DDRGK1 |
| 应用: | WB |
| 反应: | Human, Mouse |
| 分子量: | 36 kDa; 36kD(Calculated). |
| 蛋白号: | Q96HY6 |
| RRID: | AB_2845894 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF12933, RRID:AB_2845894.
展开/折叠
1110001I20Rik; 2600009E05Rik; C20orf116; Chromosome 20 open reading frame 116; Dashurin; DDRGK domain containing 1; DDRGK domain containing protein 1; DDRGK domain-containing protein 1; DDRGK_HUMAN; Ddrgk1; dJ1187M17.3; MGC2592; OTTHUMP00000030088; RGD1309979; RP23-100C5.9; UFM1-binding and PCI domain-containing protein 1;
抗原和靶标
Widely expressed (at protein level). In the brain, highest levels in medulla oblongata, followed by cerebral cortex, cerebellum and frontal lobe.
- Q96HY6 DDRGK_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MVAPVWYLVAAALLVGFILFLTRSRGRAASAGQEPLHNEELAGAGRVAQPGPLEPEEPRAGGRPRRRRDLGSRLQAQRRAQRVAWAEADENEEEAVILAQEEEGVEKPAETHLSGKIGAKKLRKLEEKQARKAQREAEEAEREERKRLESQREAEWKKEEERLRLEEEQKEEEERKAREEQAQREHEEYLKLKEAFVVEEEGVGETMTEEQSQSFLTEFINYIKQSKVVLLEDLASQVGLRTQDTINRIQDLLAEGTITGVIDDRGKFIYITPEELAAVANFIRQRGRVSIAELAQASNSLIAWGRESPAQAPA
研究背景
Protein which interacts with the E3 UFM1-protein ligase UFL1 and one of its substrates TRIP4 and is required for TRIP4 ufmylation. Through TRIP4 ufmylation may regulate nuclear receptors-mediated transcription. May play a role in NF-kappa-B-mediated transcription through regulation of the phosphorylation and the degradation of NFKBIA, the inhibitor of NF-kappa-B. May also play a role in the cellular response to endoplasmic reticulum stress (By similarity). Plays a role in cartilage development through SOX9, inhibiting the ubiquitin-mediated proteasomal degradation of this transcriptional regulator.
Ubiquitinated. Ubiquitination probably triggers proteasomal degradation and is negatively regulated by UFL1, the enzyme involved in the ufmylation of DDRGK1.
Ufmylated. Conjugated to ubiquitin-like protein UFM1, probably at Lys-267 by UFL1.
Endoplasmic reticulum.
Widely expressed (at protein level). In the brain, highest levels in medulla oblongata, followed by cerebral cortex, cerebellum and frontal lobe.
Interacts with TRIP4; the interaction with TRIP4 is direct. Interacts with UFL1. Interacts with NFKBIA. Interacts with CDK5RAP3. Interacts with SOX9.
Belongs to the DDRGK1 family.
限制条款
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