产品: COQ5 抗体
货号: DF12910
描述: Rabbit polyclonal antibody to COQ5
应用: WB
反应: Human, Mouse
预测: Pig, Bovine, Horse, Sheep, Rabbit, Dog
分子量: 37 kDa, 30 kDa; 37kD(Calculated).
蛋白号: Q5HYK3
RRID: AB_2845871

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse
预测:
Pig(92%), Bovine(83%), Horse(92%), Sheep(83%), Rabbit(83%), Dog(92%)
克隆:
Polyclonal
特异性:
COQ5 Antibody detects endogenous levels of total COQ5.
RRID:
AB_2845871
引用格式: Affinity Biosciences Cat# DF12910, RRID:AB_2845871.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

2-methoxy-6-polyprenyl-1; 4-benzoquinol methylase; COQ5; COQ5_HUMAN; mitochondrial; Ubiquinone biosynthesis methyltransferase COQ5; Ubiquinone biosynthesis methyltransferase COQ5, mitochondrial;

抗原和靶标

免疫原:
Uniprot:
基因/基因ID:
表达:
Q5HYK3 COQ5_HUMAN:

Widely expressed, with highest levels in liver, lung, placenta and skeletal muscle.

序列:
MAAPGSCALWSYCGRGWSRAMRGCQLLGLRSSWPGDLLSARLLSQEKRAAETHFGFETVSEEEKGGKVYQVFESVAKKYDVMNDMMSLGIHRVWKDLLLWKMHPLPGTQLLDVAGGTGDIAFRFLNYVQSQHQRKQKRQLRAQQNLSWEEIAKEYQNEEDSLGGSRVVVCDINKEMLKVGKQKALAQGYRAGLAWVLGDAEELPFDDDKFDIYTIAFGIRNVTHIDQALQEAHRVLKPGGRFLCLEFSQVNNPLISRLYDLYSFQVIPVLGEVIAGDWKSYQYLVESIRRFPSQEEFKDMIEDAGFHKVTYESLTSGIVAIHSGFKL

种属预测

种属预测:

score>80的预测可信度较高,可尝试用于WB检测。*预测模型主要基于免疫原序列比对,结果仅作参考,不作为质保凭据。

Species
Results
Score
Pig
92
Horse
92
Dog
92
Bovine
83
Sheep
83
Rabbit
83
Chicken
75
Xenopus
58
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - Q5HYK3 作为底物

Site PTM Type Enzyme
T58 Phosphorylation
S60 Phosphorylation
Y69 Phosphorylation
K95 Ubiquitination
Y283 Phosphorylation

研究背景

功能:

Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).

细胞定位:

Mitochondrion inner membrane>Peripheral membrane protein>Matrix side.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Widely expressed, with highest levels in liver, lung, placenta and skeletal muscle.

亚基结构:

Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.

蛋白家族:

Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.

研究领域

· Metabolism > Metabolism of cofactors and vitamins > Ubiquinone and other terpenoid-quinone biosynthesis.

· Metabolism > Global and overview maps > Metabolic pathways.

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