产品: | 磷酸化 CaMKII beta/ gamma/ delta (Thr287) 抗体 |
货号: | AF3434 |
描述: | Rabbit polyclonal antibody to Phospho-CaMKII beta/ gamma/ delta (Thr287) |
应用: | WB IHC |
反应: | Human, Mouse, Rat |
预测: | Pig, Bovine, Horse, Sheep, Rabbit, Xenopus |
分子量: | 50kDa,65kDa; 73kD,63kD,56kD(Calculated). |
蛋白号: | Q13554 | Q13555 | Q13557 |
RRID: | AB_2834876 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF3434, RRID:AB_2834876.
展开/折叠
Calcium/calmodulin-dependent protein kinase type II subunit alpha; Calcium/calmodulin-dependent protein kinase type II subunit delta; CaM kinase II subunit alpha; CaM kinase II subunit delta; CAM2; CaMK-II subunit alpha; CaMK-II subunit delta; CAMK2A; CAMK2B; CAMKA; CAMKB; CAMKD; CaMKII alpha; KIAA0968; CaM kinase II; CaM kinase II gamma chain; CaM kinase II subunit gamma; CAMK; CAMK II; CaMK II subunit gamma; CAMK2G; CAMKG; CAMKII; Calcium / calmodulin dependent protein kinase 2 delta; Calcium / calmodulin dependent protein kinase II delta; calcium/calmodulin-dependent protein kinase (CaM kinase) II delta; calcium/calmodulin-dependent protein kinase type II delta chain; Calcium/calmodulin-dependent protein kinase type II subunit delta; CAM kinase 2 delta; CAM kinase II delta; CaM kinase II delta subunit; CaM kinase II subunit delta; CaM-kinase II delta chain; CAMK 2d; CaMK-II delta subunit; CaMK-II subunit delta; CAMK2D; CAMKD; CAMKI; KCC2D_HUMAN; RATCAMKI;
抗原和靶标
Widely expressed. Expressed in adult and fetal brain. Expression is slightly lower in fetal brain. Expressed in skeletal muscle.
Q13555 KCC2G_HUMAN:Expressed in skeletal muscle.
Q13557 KCC2D_HUMAN:Expressed in cardiac muscle and skeletal muscle. Isoform Delta 3, isoform Delta 2, isoform Delta 8 and isoform Delta 9 are expressed in cardiac muscle. Isoform Delta 11 is expressed in skeletal muscle.
- Q13554 KCC2B_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MATTVTCTRFTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKLKGAILTTMLATRNFSVGRQTTAPATMSTAASGTTMGLVEQAKSLLNKKADGVKPQTNSTKNSAAATSPKGTLPPAALEPQTTVIHNPVDGIKESSDSANTTIEDEDAKAPRVPDILSSVRRGSGAPEAEGPLPCPSPAPFSPLPAPSPRISDILNSVRRGSGTPEAEGPLSAGPPPCLSPALLGPLSSPSPRISDILNSVRRGSGTPEAEGPSPVGPPPCPSPTIPGPLPTPSRKQEIIKTTEQLIEAVNNGDFEAYAKICDPGLTSFEPEALGNLVEGMDFHRFYFENLLAKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRDGKWQNVHFHCSGAPVAPLQ
- Q13555 KCC2G_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MATTATCTRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSAAKSLLNKKSDGGVKKRKSSSSVHLMPQSNNKNSLVSPAQEPAPLQTAMEPQTTVVHNATDGIKGSTESCNTTTEDEDLKGRVPEGRSSRDRTAPSAGMQPQPSLCSSAMRKQEIIKITEQLIEAINNGDFEAYTKICDPGLTSFEPEALGNLVEGMDFHKFYFENLLSKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRDGKWLNVHYHCSGAPAAPLQ
- Q13557 KCC2D_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLLKKPDGVKESTESSNTTIEDEDVKARKQEIIKVTEQLIEAINNGDFEAYTKICDPGLTAFEPEALGNLVEGMDFHRFYFENALSKSNKPIHTIILNPHVHLVGDDAACIAYIRLTQYMDGSGMPKTMQSEETRVWHRRDGKWQNVHFHRSGSPTVPIKPPCIPNGKENFSGGTSLWQNI
种属预测
score>80的预测可信度较高,可尝试用于WB检测。*预测模型主要基于免疫原序列比对,结果仅作参考,不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q13554/Q13555/Q13557 作为底物
Site | PTM Type | Enzyme | Source |
---|---|---|---|
K57 | Ubiquitination | Uniprot | |
S79 | Phosphorylation | Uniprot | |
K138 | Ubiquitination | Uniprot | |
S146 | Phosphorylation | Uniprot | |
K227 | Acetylation | Uniprot | |
K227 | Ubiquitination | Uniprot | |
Y231 | Phosphorylation | Uniprot | |
S235 | Phosphorylation | Uniprot | |
K246 | Ubiquitination | Uniprot | |
T254 | Phosphorylation | Uniprot | |
K259 | Ubiquitination | Uniprot | |
K268 | Ubiquitination | Uniprot | |
S276 | Phosphorylation | Uniprot | |
S280 | Phosphorylation | Uniprot | |
T287 | Phosphorylation | Q13554 (CAMK2B) | Uniprot |
K299 | Methylation | Uniprot | |
K301 | Methylation | Uniprot | |
T306 | Phosphorylation | Uniprot | |
T307 | Phosphorylation | Uniprot | |
T311 | Phosphorylation | Uniprot | |
S315 | Phosphorylation | Uniprot | |
T328 | Phosphorylation | Uniprot | |
K342 | Acetylation | Uniprot | |
S394 | Phosphorylation | Uniprot | |
S395 | Phosphorylation | Uniprot | |
S397 | Phosphorylation | Uniprot | |
T400 | Phosphorylation | Uniprot | |
T401 | Phosphorylation | Uniprot | |
S423 | Phosphorylation | Uniprot | |
S436 | Phosphorylation | Uniprot | |
S441 | Phosphorylation | Uniprot | |
S456 | Phosphorylation | Uniprot | |
S461 | Phosphorylation | Uniprot | |
T463 | Phosphorylation | Uniprot | |
S471 | Phosphorylation | Uniprot | |
S479 | Phosphorylation | Uniprot | |
S499 | Phosphorylation | Uniprot | |
S504 | Phosphorylation | Uniprot | |
T506 | Phosphorylation | Uniprot | |
S522 | Phosphorylation | Uniprot |
Site | PTM Type | Enzyme | Source |
---|---|---|---|
Y14 | Phosphorylation | Uniprot | |
K22 | Ubiquitination | Uniprot | |
S26 | Phosphorylation | Uniprot | |
K34 | Ubiquitination | Uniprot | |
T35 | Phosphorylation | Uniprot | |
K43 | Ubiquitination | Uniprot | |
K57 | Ubiquitination | Uniprot | |
K69 | Ubiquitination | Uniprot | |
S79 | Phosphorylation | Uniprot | |
S114 | Phosphorylation | Uniprot | |
K138 | Ubiquitination | Uniprot | |
S146 | Phosphorylation | Uniprot | |
K227 | Acetylation | Uniprot | |
K227 | Ubiquitination | Uniprot | |
Y231 | Phosphorylation | Uniprot | |
S235 | Phosphorylation | Uniprot | |
K246 | Ubiquitination | Uniprot | |
T254 | Phosphorylation | Uniprot | |
K259 | Ubiquitination | Uniprot | |
K268 | Ubiquitination | Uniprot | |
C273 | S-Nitrosylation | Uniprot | |
S276 | Phosphorylation | Uniprot | |
S280 | Phosphorylation | Q13555 (CAMK2G) | Uniprot |
T287 | Phosphorylation | Q13555 (CAMK2G) | Uniprot |
K299 | Methylation | Uniprot | |
K301 | Methylation | Uniprot | |
T306 | Phosphorylation | Uniprot | |
T307 | Phosphorylation | Uniprot | |
S311 | Phosphorylation | Uniprot | |
S315 | Phosphorylation | Uniprot | |
S319 | Phosphorylation | Q13555 (CAMK2G) | Uniprot |
S325 | Phosphorylation | Uniprot | |
S334 | Phosphorylation | Uniprot | |
S336 | Phosphorylation | Uniprot | |
S349 | Phosphorylation | Uniprot | |
S352 | Phosphorylation | Uniprot | |
T382 | Phosphorylation | Uniprot | |
S384 | Phosphorylation | Uniprot | |
T388 | Phosphorylation | Uniprot | |
S419 | Phosphorylation | Uniprot | |
S484 | Phosphorylation | Uniprot |
Site | PTM Type | Enzyme | Source |
---|---|---|---|
A2 | Acetylation | Uniprot | |
S3 | Phosphorylation | Uniprot | |
K43 | Ubiquitination | Uniprot | |
K57 | Ubiquitination | Uniprot | |
K69 | Ubiquitination | Uniprot | |
S79 | Phosphorylation | Uniprot | |
K138 | Ubiquitination | Uniprot | |
S146 | Phosphorylation | Uniprot | |
K227 | Acetylation | Uniprot | |
K227 | Ubiquitination | Uniprot | |
Y231 | Phosphorylation | Uniprot | |
S235 | Phosphorylation | Uniprot | |
K246 | Ubiquitination | Uniprot | |
K251 | Ubiquitination | Uniprot | |
T254 | Phosphorylation | Uniprot | |
S264 | Phosphorylation | Uniprot | |
S276 | Phosphorylation | Uniprot | |
S280 | Phosphorylation | Uniprot | |
T287 | Phosphorylation | Q13557 (CAMK2D) | Uniprot |
K299 | Methylation | Uniprot | |
K301 | Methylation | Uniprot | |
T306 | Phosphorylation | Uniprot | |
T307 | Phosphorylation | Uniprot | |
T311 | Phosphorylation | Uniprot | |
S315 | Phosphorylation | Uniprot | |
K318 | Acetylation | Uniprot | |
K318 | Ubiquitination | Uniprot | |
S319 | Phosphorylation | Uniprot | |
S330 | Phosphorylation | Uniprot | |
T331 | Phosphorylation | Uniprot | |
S333 | Phosphorylation | Uniprot | |
S334 | Phosphorylation | Uniprot | |
T336 | Phosphorylation | Uniprot | |
T337 | Phosphorylation | Uniprot | |
C373 | S-Nitrosylation | Uniprot | |
S404 | Phosphorylation | Uniprot | |
S441 | Phosphorylation | Uniprot | |
S472 | Phosphorylation | Uniprot | |
T474 | Phosphorylation | Uniprot | |
S490 | Phosphorylation | Uniprot |
翻译修饰 - Q13554/Q13555/Q13557 作为激酶
Substrate | Site | Source |
---|---|---|
O14490-2 (DLGAP1) | S349 | Uniprot |
O14490-2 (DLGAP1) | S393 | Uniprot |
P14921-1 (ETS1) | S251 | Uniprot |
P14921-1 (ETS1) | S257 | Uniprot |
P14921-1 (ETS1) | S282 | Uniprot |
P14921-1 (ETS1) | S285 | Uniprot |
P16949 (STMN1) | S16 | Uniprot |
P26678 (PLN) | T17 | Uniprot |
P35222 (CTNNB1) | T332 | Uniprot |
P35222 (CTNNB1) | T472 | Uniprot |
P35222 (CTNNB1) | S552 | Uniprot |
P42224 (STAT1) | S727 | Uniprot |
P49840 (GSK3A) | S21 | Uniprot |
Q01970-1 (PLCB3) | S537 | Uniprot |
Q12879-1 (GRIN2A) | S1291 | Uniprot |
Q13131 (PRKAA1) | T183 | Uniprot |
Q13224 (GRIN2B) | S383 | Uniprot |
Q13224 (GRIN2B) | S1303 | Uniprot |
Q13554-1 (CAMK2B) | T287 | Uniprot |
Q9NQC7 (CYLD) | S362 | Uniprot |
Q9NQC7 (CYLD) | S418 | Uniprot |
Q9NQC7 (CYLD) | S772 | Uniprot |
Substrate | Site | Source |
---|---|---|
O60266-1 (ADCY3) | S1076 | Uniprot |
P00533-1 (EGFR) | S1070 | Uniprot |
P00533-1 (EGFR) | S1071 | Uniprot |
P07101-1 (TH) | S19 | Uniprot |
P10276 (RARA) | T210 | Uniprot |
P17600-2 (SYN1) | S568 | Uniprot |
P17600-2 (SYN1) | S605 | Uniprot |
P18846-1 (ATF1) | S63 | Uniprot |
P21333-2 (FLNA) | S2515 | Uniprot |
P21817-1 (RYR1) | S2843 | Uniprot |
P28329 (CHAT) | T574 | Uniprot |
P35270 (SPR) | S213 | Uniprot |
P40763 (STAT3) | S727 | Uniprot |
P42224-1 (STAT1) | S727 | Uniprot |
P42261-1 (GRIA1) | S645 | Uniprot |
P42261-1 (GRIA1) | S849 | Uniprot |
P48058 (GRIA4) | S862 | Uniprot |
P55042 (RRAD) | S273 | Uniprot |
Q01970-1 (PLCB3) | S537 | Uniprot |
Q03060-16 (CREM) | S87 | Uniprot |
Q13555 (CAMK2G) | S280 | Uniprot |
Q13555 (CAMK2G) | T287 | Uniprot |
Q13555 (CAMK2G) | S319 | Uniprot |
Q15121-1 (PEA15) | S116 | Uniprot |
Q15746-1 (MYLK) | S1760 | Uniprot |
Q92934 (BAD) | S134 | Uniprot |
Q9UQL6 (HDAC5) | S259 | Uniprot |
Q9UQL6 (HDAC5) | S498 | Uniprot |
Substrate | Site | Source |
---|---|---|
O15084 (ANKRD28) | S1011 | Uniprot |
P08670 (VIM) | S83 | Uniprot |
P13688-8 (CEACAM1) | T457 | Uniprot |
P13688-8 (CEACAM1) | S459 | Uniprot |
P16220 (CREB1) | S133 | Uniprot |
P16220 (CREB1) | S142 | Uniprot |
P26678 (PLN) | T17 | Uniprot |
P55327 (TPD52) | S176 | Uniprot |
P56524 (HDAC4) | S210 | Uniprot |
P56524 (HDAC4) | S632 | Uniprot |
Q00613 (HSF1) | S230 | Uniprot |
Q03060-16 (CREM) | S87 | Uniprot |
Q08289-2 (CACNB2) | T499 | Uniprot |
Q08289 (CACNB2) | T554 | Uniprot |
Q13557 (CAMK2D) | T287 | Uniprot |
Q13557-1 (CAMK2D) | S315 | Uniprot |
Q13557-8 (CAMK2D) | S319 | Uniprot |
Q13557-1 (CAMK2D) | T331 | Uniprot |
Q13557-1 (CAMK2D) | S333 | Uniprot |
Q13557-1 (CAMK2D) | S334 | Uniprot |
Q13557-8 (CAMK2D) | T337 | Uniprot |
Q14524 (SCN5A) | S516 | Uniprot |
Q14524 (SCN5A) | T594 | Uniprot |
Q14571 (ITPR2) | S150 | Uniprot |
Q14654 (KCNJ11) | T224 | Uniprot |
Q16695 (HIST3H3) | S11 | Uniprot |
Q8WYL5 (SSH1) | S937 | Uniprot |
Q8WYL5 (SSH1) | S978 | Uniprot |
Q8WZ42 (TTN) | S4062 | Uniprot |
Q8WZ42 (TTN) | S11878 | Uniprot |
Q8WZ42 (TTN) | S12022 | Uniprot |
Q92736 (RYR2) | S2814 | Uniprot |
Q9UQL6 (HDAC5) | S498 | Uniprot |
研究背景
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2.
Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state.
Cytoplasm>Cytoskeleton. Cytoplasm>Cytoskeleton>Microtubule organizing center>Centrosome. Sarcoplasmic reticulum membrane>Peripheral membrane protein>Cytoplasmic side. Cell junction>Synapse.
Note: In slow-twitch muscle, evenly distributed between longitudinal SR and junctional SR.
Widely expressed. Expressed in adult and fetal brain. Expression is slightly lower in fetal brain. Expressed in skeletal muscle.
CAMK2 is composed of 4 different chains: alpha (CAMK2A), beta (CAMK2B), gamma (CAMK2G), and delta (CAMK2D). The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 12 subunits with two hexameric rings stacked one on top of the other Ref.19). Interacts with SYNGAP1 and CAMK2N2 (By similarity). Interacts with MPDZ. Interacts with FOXO3 (By similarity). Interacts (when in a kinase inactive state not associated with calmodulin) with ARC; leading to target ARC to inactive synapses (By similarity).
The CAMK2 protein kinases contain a unique C-terminal subunit association domain responsible for oligomerization.
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin. In the central nervous system, it is involved in the regulation of neurite formation and arborization. It may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning.
Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state.
Sarcoplasmic reticulum membrane>Peripheral membrane protein>Cytoplasmic side.
Expressed in skeletal muscle.
CAMK2 is composed of 4 different chains: alpha (CAMK2A), beta (CAMK2B), gamma (CAMK2G), and delta (CAMK2D). The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 12 subunits with two hexameric rings stacked one on top of the other.
The CAMK2 protein kinases contain a unique C-terminal subunit association domain responsible for oligomerization.
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program. Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis. May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor.
Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state.
Cell membrane>Sarcolemma>Peripheral membrane protein>Cytoplasmic side. Sarcoplasmic reticulum membrane>Peripheral membrane protein>Cytoplasmic side.
Expressed in cardiac muscle and skeletal muscle. Isoform Delta 3, isoform Delta 2, isoform Delta 8 and isoform Delta 9 are expressed in cardiac muscle. Isoform Delta 11 is expressed in skeletal muscle.
CAMK2 is composed of 4 different chains: alpha (CAMK2A), beta (CAMK2B), gamma (CAMK2G), and delta (CAMK2D). The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 12 subunits with two hexameric rings stacked one on top of the other. Interacts with RRAD and CACNB2 (By similarity).
The CAMK2 protein kinases contain a unique C-terminal subunit association domain responsible for oligomerization.
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
研究领域
· Cellular Processes > Cell growth and death > Oocyte meiosis. (View pathway)
· Cellular Processes > Cell growth and death > Necroptosis. (View pathway)
· Environmental Information Processing > Signal transduction > ErbB signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > Calcium signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > cAMP signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > HIF-1 signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > Wnt signaling pathway. (View pathway)
· Human Diseases > Substance dependence > Amphetamine addiction.
· Human Diseases > Infectious diseases: Bacterial > Tuberculosis.
· Human Diseases > Cancers: Overview > Pathways in cancer. (View pathway)
· Human Diseases > Cancers: Overview > Proteoglycans in cancer.
· Human Diseases > Cancers: Specific types > Glioma. (View pathway)
· Organismal Systems > Circulatory system > Adrenergic signaling in cardiomyocytes. (View pathway)
· Organismal Systems > Development > Axon guidance. (View pathway)
· Organismal Systems > Environmental adaptation > Circadian entrainment.
· Organismal Systems > Nervous system > Long-term potentiation.
· Organismal Systems > Nervous system > Neurotrophin signaling pathway. (View pathway)
· Organismal Systems > Nervous system > Cholinergic synapse.
· Organismal Systems > Nervous system > Dopaminergic synapse.
· Organismal Systems > Sensory system > Olfactory transduction.
· Organismal Systems > Sensory system > Inflammatory mediator regulation of TRP channels. (View pathway)
· Organismal Systems > Endocrine system > Insulin secretion. (View pathway)
· Organismal Systems > Endocrine system > Melanogenesis.
· Organismal Systems > Endocrine system > Oxytocin signaling pathway.
· Organismal Systems > Endocrine system > Glucagon signaling pathway.
· Organismal Systems > Endocrine system > Aldosterone synthesis and secretion.
· Organismal Systems > Digestive system > Gastric acid secretion.
文献引用
Application: WB Species: rat Sample:
限制条款
产品的规格、报价、验证数据请以官网为准,官网链接:www.affbiotech.com | www.affbiotech.cn(简体中文)| www.affbiotech.jp(日本語)产品的数据信息为Affinity所有,未经授权不得收集Affinity官网数据或资料用于商业用途,对抄袭产品数据的行为我们将保留诉诸法律的权利。
产品相关数据会因产品批次、产品检测情况随时调整,如您已订购该产品,请以订购时随货说明书为准,否则请以官网内容为准,官网内容有改动时恕不另行通知。
Affinity保证所销售产品均经过严格质量检测。如您购买的商品在规定时间内出现问题需要售后时,请您在Affinity官方渠道提交售后申请。产品仅供科学研究使用。不用于诊断和治疗。
产品未经授权不得转售。
Affinity Biosciences将不会对在使用我们的产品时可能发生的专利侵权或其他侵权行为负责。Affinity Biosciences, Affinity Biosciences标志和所有其他商标所有权归Affinity Biosciences LTD.