产品: KLK3 抗体
货号: AF0246
描述: Rabbit polyclonal antibody to KLK3
应用: WB IHC
反应: Human, Mouse
分子量: 34kDa; 29kD(Calculated).
蛋白号: P07288
RRID: AB_2833421

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:3000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse
克隆:
Polyclonal
特异性:
KLK3 Antibody detects endogenous levels of total KLK3.
RRID:
AB_2833421
引用格式: Affinity Biosciences Cat# AF0246, RRID:AB_2833421.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

antigen, prostate-specific; APS; Gamma seminoprotein; Gamma-seminoprotein; hK3; Kallikrein 3; Kallikrein related peptidase 3; Kallikrein-3; KLK 3; KLK2A1; Klk3; KLK3_HUMAN; P-30 antigen; P30 antigen; Prostate-specific antigen; Psa; Semenogelase; Seminin;

抗原和靶标

免疫原:
Uniprot:
基因/基因ID:
描述:
KLK3 Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum. Belongs to the peptidase S1 family. Kallikrein subfamily.
序列:
MWVPVVFLTLSVTWIGAAPLILSRIVGGWECEKHSQPWQVLVASRGRAVCGGVLVHPQWVLTAAHCIRNKSVILLGRHSLFHPEDTGQVFQVSHSFPHPLYDMSLLKNRFLRPGDDSSHDLMLLRLSEPAELTDAVKVMDLPTQEPALGTTCYASGWGSIEPEEFLTPKKLQCVDLHVISNDVCAQVHPQKVTKFMLCAGRWTGGKSTCSGDSGGPLVCNGVLQGITSWGSEPCALPERPSLYTKVVHYRKWIKDTIVANP

翻译修饰 - P07288 作为底物

Site PTM Type Enzyme
T143 Phosphorylation
T167 Phosphorylation
K251 Ubiquitination
K254 Ubiquitination

研究背景

功能:

Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.

细胞定位:

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
亚基结构:

Forms a heterodimer with SERPINA5.

蛋白家族:

Belongs to the peptidase S1 family. Kallikrein subfamily.

研究领域

· Human Diseases > Cancers: Overview > Pathways in cancer.   (View pathway)

· Human Diseases > Cancers: Specific types > Prostate cancer.   (View pathway)

文献引用

1). Pongamol Alleviates Neuroinflammation and Promotes Autophagy in Alzheimer's Disease by Regulating the Akt/mTOR Signaling Pathway. Journal of agricultural and food chemistry, 2024 (PubMed: 38841893) [IF=5.7]

2). Dihydroartemisinin-ursodeoxycholic acid conjugate is a potential treatment agent for inflammatory bowel disease. International Immunopharmacology, 2023 (PubMed: 36842236) [IF=4.8]

3). Revealing the mechanism of ethyl acetate extracts of Semen Impatientis against prostate cancer based on network pharmacology and transcriptomics. Journal of ethnopharmacology, 2024 (PubMed: 38643863) [IF=4.8]

4). Sodium Danshensu Cream Promotes the Healing of Pressure Ulcers in Mice through the Nrf2/HO-1 and NF-κB Pathways. Pharmaceuticals, 2022 (PubMed: 36558999) [IF=4.6]

Application: WB    Species: Mouse    Sample:

Figure 7. Effect of SDSS on the protein levels of the NF-κB pathway (n = 5). (A) Western blot; the protein expression levels of NF-κB p65 (B), NF-κB p50 (C), IKKα (D), IKKβ (E), and IκBα (F) levels. * p < 0.05, ** p < 0.01 when compared to the control group. # p < 0.05, ## p < 0.01 when compared to the positive group.

5). Sodium acetate alleviated high-carbohydrate induced intestinal inflammation by suppressing MAPK and NF-κB signaling pathways in Nile tilapia (Oreochromis niloticus). Fish & Shellfish Immunology, 2020 (PubMed: 31730927) [IF=4.1]

6). Wenshenqianlie capsule improves benign prostatic hyperplasia via its anti-inflammatory and antioxidant effects. Aging, 2024 (PubMed: 39237304) [IF=3.9]

Application: IHC    Species: Mouse    Sample:

Figure 3. WSQL improved BPH symptoms and reduced serum hormone and growth factor levels. (A) IHC staining for PSA in prostate. Magnification: 200×, scale bar: 50 μm. (B) Quantitative analyses of IHC staining for PSA in prostate were reported as the fold change of the Ctrl group. Effect of WSQL on levels of (C) DHT, (D) T, (E) ASD and (F) TGF-α in serum. The data are presented as the mean ± SEM. ### p < 0.001, ## p < 0.01 and # p < 0.05 vs. Ctrl group, *** p < 0.001, ** p < 0.01 and * p < 0.05 vs. BPH group. n = 3 for (A) and (B) and n = 6 for (C–F).

7). The beneficial effects of Rosuvastatin in inhibiting inflammation in sepsis. Aging, 2024 (PubMed: 38885061) [IF=3.9]

8). Laminaria japonica fucoidan ameliorates cyclophosphamide‐induced liver and kidney injury possibly by regulating Nrf2/HO‐1 and TLR4/NF‐κB signaling pathways. Journal of the Science of Food and Agriculture, 2022 (PubMed: 34689333) [IF=3.3]

9). Capsaicin reduces blood glucose and prevents prostate growth by regulating androgen, RAGE/IGF-1/Akt, TGF-β/Smad signalling pathway and reversing epithelial-mesenchymal transition in streptozotocin-induced diabetic mice. Naunyn-Schmiedeberg's archives of pharmacology, 2024 (PubMed: 38700794) [IF=3.1]

10). Pyrroloquinoline quinone ameliorates liver injury in mice induced by cyclophosphamide. Environmental Science and Pollution Research, 2022 (PubMed: 34997497)

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