| 产品: | CCM2 抗体 |
| 货号: | DF12886 |
| 描述: | Rabbit polyclonal antibody to CCM2 |
| 应用: | WB |
| 反应: | Human, Mouse |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| 分子量: | 52 kDa; 49kD(Calculated). |
| 蛋白号: | Q9BSQ5 |
| RRID: | AB_2845847 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF12886, RRID:AB_2845847.
展开/折叠
C7orf22; Ccm2; CCM2 gene; CCM2_HUMAN; Cerebral cavernous malformation 2; Cerebral cavernous malformations 2 protein; Chromosome 7 open reading frame 22; Malcavernin; MGC4067; MGC4607; MGC74868; OSM; Osmosensing scaffold for MEKK3; OTTHUMP00000159554; OTTHUMP00000214270; OTTHUMP00000214271; OTTHUMP00000214273; PP10187;
抗原和靶标
- Q9BSQ5 CCM2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEEEGKKGKKPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLSDYIEKEVKYLGQLTSIPGYLNPSSRTEILHFIDNAKRAHQLPGHLTQEHDAVLSLSAYNVKLAWRDGEDIILRVPIHDIAAVSYVRDDAAHLVVLKTAQDPGISPSQSLCAESSRGLSAGSLSESAVGPVEACCLVILAAESKVAAEELCCLLGQVFQVVYTESTIDFLDRAIFDGASTPTHHLSLHSDDSSTKVDIKETYEVEASTFCFPESVDVGGASPHSKTISESELSASATELLQDYMLTLRTKLSSQEIQQFAALLHEYRNGASIHEFCINLRQLYGDSRKFLLLGLRPFIPEKDSQHFENFLETIGVKDGRGIITDSFGRHRRALSTTSSSTTNGNRATGSSDDRSAPSEGDEWDRMISDISSDIEALGCSMDQDSA
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9BSQ5 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K6 | Acetylation | Uniprot | |
| S15 | Phosphorylation | Uniprot | |
| K65 | Ubiquitination | Uniprot | |
| Y69 | Phosphorylation | Uniprot | |
| K96 | Ubiquitination | Uniprot | |
| S164 | Phosphorylation | Uniprot | |
| S168 | Phosphorylation | Uniprot | |
| S238 | Phosphorylation | Uniprot | |
| T239 | Phosphorylation | Uniprot | |
| T241 | Phosphorylation | Uniprot | |
| S248 | Phosphorylation | Uniprot | |
| S280 | Phosphorylation | Uniprot | |
| S384 | Phosphorylation | O00506 (STK25) | Uniprot |
| S393 | Phosphorylation | Uniprot | |
| T394 | Phosphorylation | Uniprot | |
| S396 | Phosphorylation | Uniprot | |
| S397 | Phosphorylation | Uniprot | |
| S398 | Phosphorylation | Uniprot | |
| S416 | Phosphorylation | Uniprot |
研究背景
Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity).
Cytoplasm.
Part of a complex with MAP2K3, MAP3K3 and RAC1. Binds RAC1 directly and independently of its nucleotide-bound state (By similarity). Interacts with HEG1 and KRIT1; KRIT1 greatly facilitates the interaction with HEG1 (By similarity). Interacts with PDCD10.
The C-terminal region constitutes an independently folded domain that has structural similarity with the USH1C (harmonin) N-terminus, despite very low sequence similarity.
Belongs to the CCM2 family.
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