Cathepsin L Antibody - #DF12880

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产品: Cathepsin L 抗体
货号: DF12880
描述: Rabbit polyclonal antibody to Cathepsin L
应用: WB IF/ICC
文献验证: WB
反应: Human, Mouse
蛋白号: P07711
RRID: AB_2845841

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MS Report
HPLC Report
MSDS
说明书
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实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse
克隆:
Polyclonal
特异性:
Cathepsin L Antibody detects endogenous levels of total Cathepsin L.
RRID:
AB_2845841
引用格式: Affinity Biosciences Cat# DF12880, RRID:AB_2845841.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Cathepsin L; cathepsin L, 1 b; Cathepsin L1; Cathepsin L1 light chain; CathepsinL; CATL; CATL1_HUMAN; cb15; CTSL; CTSL1; ctsl1b; FLJ31037; hgg1; Major excreted protein; MEP; MGC123162; wu:fb30g09;

抗原和靶标

免疫原:

A synthesized peptide derived from human Cathepsin L, corresponding to a region within the internal amino acids.

基因/基因ID:
CTSL(1514)

研究领域

· Cellular Processes > Transport and catabolism > Autophagy - animal.   (View pathway)

· Cellular Processes > Transport and catabolism > Lysosome.   (View pathway)

· Cellular Processes > Transport and catabolism > Phagosome.   (View pathway)

· Cellular Processes > Cell growth and death > Apoptosis.   (View pathway)

· Human Diseases > Cancers: Overview > Proteoglycans in cancer.

· Human Diseases > Immune diseases > Rheumatoid arthritis.

· Organismal Systems > Immune system > Antigen processing and presentation.   (View pathway)

文献引用

1). TFE3 regulates the function of the autophagy-lysosome pathway to drive the invasion and metastasis of papillary thyroid carcinoma. Analytical Cellular Pathology, 2021 (PubMed: 34660181) [IF=2.6]

Application: WB    Species: Human    Sample: PTC cells

Figure 5 TFE3 induces autophagy-lysosome in PTC cells. (a, b) After transfection with pcDNA3.1-TFE3 or si-TFE3, BCPAP and KTC-1 cells showed significant changes in TFE3 protein levels. Overexpression of TFE3 increased the expression of P62/SQSTM1, and the opposite results were observed in BCPAP and KTC-1 cells transfected with si-TFE3. The ratio of LC3II/LC3Iin BCPAP and KTC-1 cells increased significantly after pcDNA3.1-TFE3 transfection, and the opposite results appeared after si-TFE3 transfection. (c) After knocking down TFE3, the expression of LC3 and P62/SQSTM1 in PTC cells was decreased, and overexpression of TFE3 increased the expression of LC3 and P62/SQSTM1 in PTC cells (∗P < 0.05). (d) After knocking down TFE3, the expression of CTSB and CTSL in PTC cells was decreased, while TFE3 is overexpression, the expression of CTSB and CTSL in PTC cells increased (∗P < 0.05).
2). Proteome-wide analysis of the hippocampus in adolescent male mice with learning and memory impairment caused by chronic ethanol exposure. Neurobiology of learning and memory, 2022 (PubMed: 35878712) [IF=2.2]

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