SLC11A2 Antibody - #DF12740

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产品: SLC11A2 抗体
货号: DF12740
描述: Rabbit polyclonal antibody to SLC11A2
应用: WB IHC
文献验证: WB
反应: Human, Mouse, Rat
预测: Bovine, Horse
蛋白号: P49281
RRID: AB_2845701

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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产品描述

来源:
Rabbit
应用:
IHC 1:50-1:200, WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
SLC11A2 Antibody detects endogenous levels of total SLC11A2.
RRID:
AB_2845701
引用格式: Affinity Biosciences Cat# DF12740, RRID:AB_2845701.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

DCT 1; dct-1; DCT1; Divalent cation transporter 1; Divalent metal transporter 1; DMT 1; DMT-1; DMT1; FLJ37416; Natural resistance associated macrophage protein 2; Natural resistance-associated macrophage protein 2; NRAM2_HUMAN; NRAMP 2; NRAMP2; OK/SW-cl.20; Slc11a2; Solute carrier family 11 (proton coupled divalent metal ion transporters) member 2; Solute carrier family 11 member 2;

抗原和靶标

免疫原:

A synthesized peptide derived from human SLC11A2, corresponding to a region within N-terminal amino acids.

基因/基因ID:
SLC11A2(4891)

研究领域

· Cellular Processes > Transport and catabolism > Lysosome.   (View pathway)

· Cellular Processes > Cell growth and death > Ferroptosis.   (View pathway)

· Organismal Systems > Digestive system > Mineral absorption.

文献引用

1). Bone morphogenetic protein 4 derived from the cerebrospinal fluid in patients with postherpetic neuralgia induces allodynia via the crosstalk between microglia and astrocyte. Brain, behavior, and immunity, 2024 (PubMed: 38735405) [IF=8.8]
2). Magnetic graphene oxide nanocomposites induce cytotoxicity in ADSCs via GPX4 regulating ferroptosis. Ecotoxicology and environmental safety, 2024 (PubMed: 38029583) [IF=6.2]
3). Repurposing flubendazole for glioblastoma ferroptosis by affecting xCT and TFRC proteins. Journal of cellular and molecular medicine, 2024 (PubMed: 39543084) [IF=5.3]

Application: WB    Species: Human    Sample: LN229 and U251 cells

FIGURE 4. Flubendazole affects ferroptosis‐related protein expression in glioblastoma cells. (A, B) After the drug treatment, LN229 and U251 cells showed decreased expression of xCT, FHL and GPX 4, Accumulation of TFRC, DMT 1 and p53 (Flubendazole, 0, 0.125, 0.25, 0.5 μM, 24 h); (C, D) GPX4 depletion in U251 and LN229 cells treated with drugs (Flubendazole, 0.5 μM, 24 h; 400X, 1: 50 μm). (E–G) Flubendazole binds to two sites 229 Gly and 314 Arg in xCT protein. (2D diagram); (F, H) Flubendazole binds to two sites 457 Thr and 516 Gly in TFRC protein. (Student's t‐test was used.).
4). Prostaglandin endoperoxide synthase 2 regulates neuroinflammation to mediate postoperative cognitive dysfunction in mice. Scientific reports, 2025 (PubMed: 40389478) [IF=3.8]

Application: WB    Species: Mouse    Sample:

Fig. 5 PTGS2 mediation of hippocampal oxidative damage in the development of POCD.
5). Bavachin Induces Ferroptosis through the STAT3/P53/SLC7A11 Axis in Osteosarcoma Cells. Oxidative medicine and cellular longevity, 2021 (PubMed: 34707773)

Application: WB    Species: Human    Sample: OS cells

Figure 2 Bavachin-induced ferrous iron accumulation initiates death of osteosarcoma (OS) cells. (a) Bavachin (24 h) induced ferrous iron accumulation in OS cells occurs in a concentration-dependent manner. (b) Deferoxamine (DFO) rescues cells from bavachin-induced cell death. (c, d) Western blotting analysis shows the protein levels of transferrin receptor (TFRC), divalent metal transporter-1 (DMT1), ferritin light chain (FTH), and ferritin heavy chain (FTL) in MG63 and HOS cells treated with bavachin (10 μM, 20 μM, and 40 μM) for 24 h. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, and #p < 0.001 vs. the control group.

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