| 产品: | RMI1 抗体 |
| 货号: | DF12724 |
| 描述: | Rabbit polyclonal antibody to RMI1 |
| 应用: | WB |
| 反应: | Human |
| 分子量: | 75 kDa; 70kD(Calculated). |
| 蛋白号: | Q9H9A7 |
| RRID: | AB_2845685 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF12724, RRID:AB_2845685.
展开/折叠
BLAP75; BLM associated polypeptide 75 kDa; BLM associated protein 75 kDa; BLM-associated protein of 75 kDa; C9orf76; FAAP75; FLJ12888; Homolog of yeast RecQ mediated genome instability 1; RecQ mediated genome instability 1; RecQ-mediated genome instability protein 1; Rmi1; RMI1 homolog; RMI1 RecQ mediated genome instability 1 homolog; RMI1_HUMAN; RP11-346I8;
抗原和靶标
- Q9H9A7 RMI1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MNVTSIALRAETWLLAAWHVKVPPMWLEACINWIQEENNNVNLSQAQMNKQVFEQWLLTDLRDLEHPLLPDGILEIPKGELNGFYALQINSLVDVSQPAYSQIQKLRGKNTTNDLVTAEAQVTPKPWEAKPSRMLMLQLTDGIVQIQGMEYQPIPILHSDLPPGTKILIYGNISFRLGVLLLKPENVKVLGGEVDALLEEYAQEKVLARLIGEPDLVVSVIPNNSNENIPRVTDVLDPALGPSDEELLASLDENDELTANNDTSSERCFTTGSSSNTIPTRQSSFEPEFVISPRPKEEPSNLSIHVMDGELDDFSLEEALLLEETVQKEQMETKELQPLTFNRNADRSIERFSHNPNTTNNFSLTCKNGNNNWSEKNVSEQMTNEDKSFGCPSVRDQNRSIFSVHCNVPLAHDFTNKEKNLETDNKIKQTSSSDSHSLNNKILNREVVNYVQKRNSQISNENDCNLQSCSLRSSENSINLSIAMDLYSPPFVYLSVLMASKPKEVTTVKVKAFIVTLTGNLSSSGGIWSITAKVSDGTAYLDVDFVDEILTSLIGFSVPEMKQSKKDPLQYQKFLEGLQKCQRDLIDLCCLMTISFNPSLSKAMVLALQDVNMEHLENLKKRLNK
翻译修饰 - Q9H9A7 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| T4 | Phosphorylation | Uniprot | |
| K109 | Ubiquitination | Uniprot | |
| T111 | Phosphorylation | Uniprot | |
| T112 | Phosphorylation | Uniprot | |
| T123 | Phosphorylation | Uniprot | |
| K125 | Ubiquitination | Uniprot | |
| K130 | Ubiquitination | Uniprot | |
| S132 | Phosphorylation | Uniprot | |
| K205 | Ubiquitination | Uniprot | |
| S219 | Phosphorylation | Uniprot | |
| S225 | Phosphorylation | Uniprot | |
| S250 | Phosphorylation | Uniprot | |
| T277 | Phosphorylation | Uniprot | |
| T280 | Phosphorylation | Uniprot | |
| S283 | Phosphorylation | Uniprot | |
| S284 | Phosphorylation | Uniprot | |
| S292 | Phosphorylation | Uniprot | |
| K334 | Sumoylation | Uniprot | |
| K334 | Ubiquitination | Uniprot | |
| T359 | Phosphorylation | Uniprot | |
| S363 | Phosphorylation | Uniprot | |
| K376 | Ubiquitination | Uniprot | |
| T383 | Phosphorylation | Uniprot | |
| K387 | Ubiquitination | Uniprot | |
| S388 | Phosphorylation | Uniprot | |
| S400 | Phosphorylation | Uniprot | |
| S403 | Phosphorylation | Uniprot | |
| T415 | Phosphorylation | Uniprot | |
| K428 | Ubiquitination | Uniprot | |
| K441 | Ubiquitination | Uniprot | |
| Y450 | Phosphorylation | Uniprot | |
| K453 | Ubiquitination | Uniprot | |
| S456 | Phosphorylation | Uniprot | |
| S524 | Phosphorylation | Uniprot | |
| K566 | Ubiquitination | Uniprot | |
| K573 | Ubiquitination | Uniprot | |
| K580 | Ubiquitination | Uniprot |
研究背景
Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.
Nucleus.
Note: Forms foci in response to DNA damage.
Component of the RMI complex, containing at least TOP3A, RMI1 and RMI2. The RMI complex interacts with BLM. Directly interacts with RMI2 and TOP3A. May bind DHJ. Interacts (via N-terminal region) with BLM; the interaction is direct.
Belongs to the RMI1 family.
研究领域
· Genetic Information Processing > Replication and repair > Fanconi anemia pathway.
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