PCSK9 Antibody - #DF12687

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产品: PCSK9 抗体
货号: DF12687
描述: Rabbit polyclonal antibody to PCSK9
应用: WB IF/ICC
文献验证: WB
反应: Human, Mouse, Rat
预测: Pig, Zebrafish, Horse, Rabbit, Xenopus
蛋白号: Q8NBP7
RRID: AB_2845649

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   规格 价格 库存
 50ul RMB¥ 1500 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MS Report
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说明书
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实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
PCSK9 Antibody detects endogenous levels of total PCSK9.
RRID:
AB_2845649
引用格式: Affinity Biosciences Cat# DF12687, RRID:AB_2845649.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Convertase subtilisin/kexin type 9 preproprotein; FH3; HCHOLA3; Hypercholesterolemia autosomal dominant 3; LDLCQ1; NARC 1; NARC-1; NARC1; Neural apoptosis regulated convertase 1; Neural apoptosis-regulated convertase 1; PC 9; PC9; PCSK 9; PCSK9; PCSK9_HUMAN; Proprotein convertase 9; Proprotein convertase PC9; Proprotein convertase subtilisin/kexin type 9; PSEC0052; Subtilisin/kexin like protease PC9; Subtilisin/kexin-like protease PC9;

抗原和靶标

免疫原:

A synthesized peptide derived from human PCSK9, corresponding to a region within the internal amino acids.

基因/基因ID:
PCSK9(255738)

研究领域

· Organismal Systems > Digestive system > Cholesterol metabolism.

文献引用

1). Decreased protein activator of interferon induced protein kinase (PRKRA) involved in menopause-related cholesterol metabolic disorders by regulating cholesterol biosynthesis. Lipids in health and disease, 2025 (PubMed: 40349061) [IF=4.5]

Application: WB    Species: human    Sample: HepG2 cells

Fig. 5 Transcriptomic analysis revealed significant enrichment of the cholesterol synthesis pathway in PRKRA knockdown cells. (A) Differentially expressed genes in the si-NC vs. si-1 comparison in HepG2 cells. (B) A cluster heatmap displayed the gene expression profiles between si-NC and si-1groups. (C) Gene set enrichment analysis demonstrated significant upregulation of the cholesterol biosynthesis pathway in the si-PRKRA group. (D) A bubble chart illustrating the results of the Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses demonstrating that the cholesterol biosynthesis pathway was enriched in the PRKRA knockdown group. (E) The mRNA levels of genes associated with cholesterol synthesis in HepG2 cells. (F-G) The protein levels of molecules associated with cholesterol synthesis and LDL uptake in HepG2 cells. (H-I) The protein levels of molecules associated with cholesterol metabolism in HuH7 cells. The data are shown as the mean ± SEM. Statistical significance is denoted as *P 

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