ATP1A1 Antibody - #AF6083

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产品: ATP1A1 抗体
货号: AF6083
描述: Rabbit polyclonal antibody to ATP1A1
应用: WB IHC IF/ICC
文献验证: WB
反应: Human, Mouse, Rat
预测: Pig, Bovine, Horse, Sheep, Rabbit, Dog
蛋白号: P05023
RRID: AB_2834852

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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说明书
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实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
ATP1A1 Antibody detects endogenous levels of total ATP1A1.
RRID:
AB_2834852
引用格式: Affinity Biosciences Cat# AF6083, RRID:AB_2834852.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

A1A1; AT1A1; AT1A1_HUMAN; ATP1A1; Atpa-1; ATPase Na+/K+ transporting alpha 1 polypeptide; ATPase Na+/K+ transporting subunit alpha 1; BC010319; EC 3.6.3.9; MGC3285; MGC38419; MGC51750; Na K ATPase alpha A catalytic polypeptide; Na K ATPase catalytic subunit alpha A protein; Na(+)/K(+) ATPase 1; Na(+)/K(+) ATPase alpha-1 subunit; Na+, K+ ATPase alpha subunit; Na+/K+ ATPase alpha 1 subunit; Na+/K+ ATPase 1; Na,K ATPase alpha 1 subunit; Nkaa1b; Sodium potassium ATPase alpha 1 polypeptide; Sodium pump 1; Sodium pump subunit alpha-1; sodium-potassium ATPase catalytic subunit alpha-1; Sodium/potassium-transporting ATPase subunit alpha-1;

抗原和靶标

免疫原:

A synthesized peptide derived from human ATP1A1, corresponding to a region within N-terminal amino acids.

基因/基因ID:
ATP1A1(476)
描述:
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane.

研究领域

· Environmental Information Processing > Signal transduction > cGMP-PKG signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > cAMP signaling pathway.   (View pathway)

· Organismal Systems > Circulatory system > Cardiac muscle contraction.   (View pathway)

· Organismal Systems > Circulatory system > Adrenergic signaling in cardiomyocytes.   (View pathway)

· Organismal Systems > Endocrine system > Insulin secretion.   (View pathway)

· Organismal Systems > Endocrine system > Thyroid hormone synthesis.

· Organismal Systems > Endocrine system > Thyroid hormone signaling pathway.   (View pathway)

· Organismal Systems > Endocrine system > Aldosterone synthesis and secretion.

· Organismal Systems > Excretory system > Aldosterone-regulated sodium reabsorption.

· Organismal Systems > Excretory system > Endocrine and other factor-regulated calcium reabsorption.

· Organismal Systems > Excretory system > Proximal tubule bicarbonate reclamation.

· Organismal Systems > Digestive system > Salivary secretion.

· Organismal Systems > Digestive system > Gastric acid secretion.

· Organismal Systems > Digestive system > Pancreatic secretion.

· Organismal Systems > Digestive system > Carbohydrate digestion and absorption.

· Organismal Systems > Digestive system > Protein digestion and absorption.

· Organismal Systems > Digestive system > Mineral absorption.

文献引用

1). Compared with High-intensity Interval Exercise, Moderate Intensity Constant Load Exercise is more effective in curbing the Growth and Metastasis of Lung Cancer. Journal of Cancer, 2022 (PubMed: 35371324) [IF=3.3]

Application: WB    Species: Mice    Sample: lung cancer tissues

Figure 5 The effect of exercise on EMT and its inducing factors in lung cancer tissues. A, B. The expression level of E-cadherin in lung cancer tissues (n=6). A, C. N-cadherin expression level in lung cancer tissues (n=6). D, E. The expression level of vimentin in lung cancer tissues (n=6). D, F, G. The expression levels of MMP2 (D, F) and MMP9 (D, G) in lung cancer tissues (n=6). D, H. The expression level of TGF-β1 in lung cancer tissues (n=6). D, I. The expression level of collagen type I in lung cancer tissues (n=6). Note: &, &&&& respectively represent a significant difference compared with the Saline group (P<0.05), (P<0.0001). *, ** respectively represent significant differences compared with CON group (P < 0.05), (P < 0.01).

Application: WB    Species: mouse    Sample: lung cancer

Figure 5.| The effect of exercise on EMT and its inducing factors in lung cancer tissues. A, B. The expression level of E-cadherin in lung cancer tissues (n=6). A, C.N-cadherin expression level in lung cancer tissues (n=6).
2). Exercise modulates polarization of TAMs and expression of related immune checkpoints in mice with lung cancer. Journal of Cancer, 2022 (PubMed: 36186906) [IF=3.3]

Application: WB    Species: Mouse    Sample: lung cancer tissues

Figure 3. The effect of exercise on the expression of immune checkpoints in lung cancer tissues. A: Tumor cell-associated ligand mRNA expression levels (n=8). B: mRNA expression level of the receptor (n=8). C, D, E, F, G: Expression levels of CD47 (C, D), CD24 (C, E), H2KD (C, F) and PD-L1 (C, G) in lung cancer tissues (n=6). C, H, I: Expression levels of SIRPα (C, H) and PD-1 (C, I) in lung cancer tissues (n=6). Note: & represents significant difference compared with Saline group (P
3). Glutamine Enhances the Hypoglycemic Effect of Insulin in L6 Cells via Phosphatidylinositol-3-Kinase (PI3K)/Protein Kinase B (AKT)/Glucose Transporter 4 (GLUT4) Signaling Pathway. MEDICAL SCIENCE MONITOR, 2018 (PubMed: 29491345) [IF=2.2]

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