| 产品: | LDB3 抗体 |
| 货号: | DF12652 |
| 描述: | Rabbit polyclonal antibody to LDB3 |
| 应用: | WB |
| 反应: | Human, Mouse, Rat |
| 预测: | Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 32/78 kDa; 77kD(Calculated). |
| 蛋白号: | O75112 |
| RRID: | AB_2845614 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF12652, RRID:AB_2845614.
展开/折叠
CMD1C; CYPHER; HGNC:15710; KIAA01613; KIAA0613; Ldb3; LDB3_HUMAN; LDB3Z1; LDB3Z4; LIM domain binding 3; LIM domain binding protein 3; LIM domain-binding protein 3; LVNC3; ORACLE; PDLIM6; PDZ and LIM domain 6; Protein cypher; Z band alternatively spliced PDZ motif; Z band alternatively spliced PDZ motif protein; Z-band alternatively spliced PDZ-motif protein; ZASP;
抗原和靶标
Expressed primarily in skeletal muscle and to a lesser extent in heart. Also detected in brain and placenta.
- O75112 LDB3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSYSVTLTGPGPWGFRLQGGKDFNMPLTISRITPGSKAAQSQLSQGDLVVAIDGVNTDTMTHLEAQNKIKSASYNLSLTLQKSKRPIPISTTAPPVQTPLPVIPHQKDPALDTNGSLVAPSPSPEARASPGTPGTPELRPTFSPAFSRPSAFSSLAEASDPGPPRASLRAKTSPEGARDLLGPKALPGSSQPRQYNNPIGLYSAETLREMAQMYQMSLRGKASGVGLPGGSLPIKDLAVDSASPVYQAVIKSQNKPEDEADEWARRSSNLQSRSFRILAQMTGTEFMQDPDEEALRRSSTPIEHAPVCTSQATTPLLPASAQPPAAASPSAASPPLATAAAHTAIASASTTAPASSPADSPRPQASSYSPAVAASSAPATHTSYSEGPAAPAPKPRVVTTASIRPSVYQPVPASTYSPSPGANYSPTPYTPSPAPAYTPSPAPAYTPSPVPTYTPSPAPAYTPSPAPNYNPAPSVAYSGGPAEPASRPPWVTDDSFSQKFAPGKSTTSISKQTLPRGGPAYTPAGPQVPPLARGTVQRAERFPASSRTPLCGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLCAKCNTKIMGEVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEAGDKFIEALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLCKKHAHTINL
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - O75112 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Phosphorylation | Uniprot | |
| K21 | Sumoylation | Uniprot | |
| S44 | Phosphorylation | Uniprot | |
| S71 | Phosphorylation | Uniprot | |
| Y74 | Phosphorylation | Uniprot | |
| T98 | Phosphorylation | Uniprot | |
| T113 | Phosphorylation | Uniprot | |
| S116 | Phosphorylation | Uniprot | |
| S129 | Phosphorylation | Uniprot | |
| K171 | Ubiquitination | Uniprot | |
| Y202 | Phosphorylation | Uniprot | |
| S243 | Phosphorylation | Uniprot | |
| Y246 | Phosphorylation | Uniprot | |
| S267 | Phosphorylation | Uniprot | |
| S268 | Phosphorylation | Uniprot | |
| T513 | Phosphorylation | Uniprot | |
| Y521 | Phosphorylation | Uniprot | |
| Y579 | Phosphorylation | Uniprot | |
| Y656 | Phosphorylation | Uniprot | |
| Y661 | Phosphorylation | Uniprot | |
| S666 | Phosphorylation | Uniprot | |
| T667 | Phosphorylation | Uniprot | |
| K712 | Acetylation | Uniprot | |
| K713 | Acetylation | Uniprot |
研究背景
May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton.
Cytoplasm>Perinuclear region. Cell projection>Pseudopodium. Cytoplasm>Cytoskeleton. Cytoplasm>Myofibril>Sarcomere>Z line.
Note: Localized to the cytoplasm around nuclei and pseudopodia of undifferentiated cells and detected throughout the myotubes of differentiated cells. Colocalizes with ACTN2 at the Z-lines.
Expressed primarily in skeletal muscle and to a lesser extent in heart. Also detected in brain and placenta.
Interacts via its LIM domains with various PKC isoforms (By similarity). Interacts via its PDZ domain with the ACTN2 C-terminal region. Interacts with MYOZ1, MYOZ2 and MYOZ3.
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