NR1H4 Antibody - #DF12511

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产品: NR1H4 抗体
货号: DF12511
描述: Rabbit polyclonal antibody to NR1H4
应用: WB IHC
文献验证: WB
反应: Human, Rat
预测: Pig, Bovine, Horse, Sheep, Rabbit, Dog
蛋白号: Q96RI1
RRID: AB_2845473

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   规格 价格 库存
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MS Report
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实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:100
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Rat
克隆:
Polyclonal
特异性:
NR1H4 Antibody detects endogenous levels of total NR1H4.
RRID:
AB_2845473
引用格式: Affinity Biosciences Cat# DF12511, RRID:AB_2845473.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

BAR; Bile acid receptor; Farnesoid X activated receptor; Farnesoid X receptor; Farnesoid X-activated receptor; Farnesol receptor HRR 1; Farnesol receptor HRR-1; Farnesol receptor HRR1; FXR; HRR 1; HRR1; NR1H4; NR1H4_HUMAN; Nuclear receptor subfamily 1 group H member 4; Retinoid X receptor interacting protein 14; Retinoid X receptor-interacting protein 14; RIP 14; RIP14; RXR interacting protein 14; RXR-interacting protein 14;

抗原和靶标

免疫原:

A synthesized peptide derived from human NR1H4, corresponding to a region within N-terminal amino acids.

基因/基因ID:
NR1H4(9971)

文献引用

1). Saikosaponin D improves non-alcoholic fatty liver disease via gut microbiota-bile acid metabolism pathway. Food Science and Human Wellness, 2024 [IF=7.0]

Application: WB    Species: Mouse    Sample:

Fig. 3. SSD increased liver fatty acid oxidation and inhibited intestinal FXR signal in NAFLD mice. (A) Expression levels of liver fatty acid synthesis-related genes (n = 5). (B) Liver fatty acid oxidation-related gene expression level (n = 5). (C) Liver fatty acid oxidation-related protein expression. (D) The expression level of liver bile acid synthesis related genes. (E) Expression levels of FXR target genes (n = 5). (F) Protein expression level of intestinal FXR (n = 5). Compared with HFD group in same gene, *P < 0.05, **P < 0.01, ***P < 0.001. Compared with NCD group in same gene, #P < 0.05, ##P < 0.01, ###P < 0.001. All experiments were repeated 3 times.
2). NRF2 and FXR dual signaling pathways cooperatively regulate the effects of oleanolic acid on cholestatic liver injury. Phytomedicine, 2023 (PubMed: 36343550) [IF=6.7]
3). Ginsenosides From Panax ginseng Improves Hepatic Lipid Metabolism Disorders in HFD-Fed Rats by Regulating Gut Microbiota and Cholesterol Metabolism Signaling Pathways. Phytotherapy research : PTR, 2024 (PubMed: 39660634) [IF=6.1]
4). Construction of Humanized CYP1A2 Rats Using CRISPR/CRISPR-Associated Protein 9 to Promote Drug Metabolism and Pharmacokinetic Research. Drug Metabolism and Disposition, 2024 (PubMed: 37884392)

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