Phospho-RYR2 (Ser2808) Antibody - #AF7454

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产品: 磷酸化RYR2 (Ser2808) 抗体
货号: AF7454
描述: Rabbit polyclonal antibody to Phospho-RYR2 (Ser2808)
应用: WB IHC
文献验证: WB
反应: Human, Mouse, Rat
预测: Pig, Bovine, Horse, Sheep, Rabbit
蛋白ID: Q92736
RRID: AB_2845459

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Phospho-RYR2 (Ser2808) Peptide

1mg
相关下载
抗原肽/阻断肽MS报告
抗原肽/阻断肽HPLC报告
MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
Phospho-RYR2 (Ser2808) Antibody detects endogenous levels of RYR2 only when phosphorylated at Ser2808.
RRID:
AB_2845459
引用格式: Affinity Biosciences Cat# AF7454, RRID:AB_2845459.
偶联:
Unconjugated.
纯化:
The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

ARVC2; ARVD2; Cardiac muscle ryanodine receptor; Cardiac muscle ryanodine receptor-calcium release channel; hRYR-2; ryanodine receptor 2 (cardiac); Ryanodine receptor 2; RyR; RYR-2; RyR2; RYR2_HUMAN; Type 2 ryanodine receptor; VTSIP;

抗原和靶标

免疫原:

A synthesized peptide derived from human RYR2 around the phosphorylation site of Ser2808.

基因/基因ID:
RYR2(6262)

研究领域

· Environmental Information Processing > Signal transduction > Calcium signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > cAMP signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > Apelin signaling pathway.   (View pathway)

· Human Diseases > Cardiovascular diseases > Hypertrophic cardiomyopathy (HCM).

· Human Diseases > Cardiovascular diseases > Arrhythmogenic right ventricular cardiomyopathy (ARVC).

· Human Diseases > Cardiovascular diseases > Dilated cardiomyopathy (DCM).

· Organismal Systems > Circulatory system > Cardiac muscle contraction.   (View pathway)

· Organismal Systems > Circulatory system > Adrenergic signaling in cardiomyocytes.   (View pathway)

· Organismal Systems > Environmental adaptation > Circadian entrainment.

· Organismal Systems > Endocrine system > Insulin secretion.   (View pathway)

· Organismal Systems > Endocrine system > Oxytocin signaling pathway.

· Organismal Systems > Digestive system > Pancreatic secretion.

文献引用

1). Alzheimer's-like signaling in brains of COVID-19 patients. Alzheimer's & Dementia, 2022 (PubMed: 35112786) [IF=13.0]

Application: WB    Species: Human    Sample: brain

FIGURE3Dysregulationofcalcium-handlingproteinsinCOVID-19brains.A,Westernblotsdepictingryanodinereceptor2(RyR2)oxidation,proteinkinaseA(PKA)phosphorylation,andcalstabin2orNADPHoxidase2(NOX2)boundtothechannelfrombrain(CB,cerebellum;Ctx,cortex)lysates.B,BargraphsquantifyingDNP/RyR2,pS2808/RyR2,andcalstabin2andNOX2boundtothechannelfromtheWesternblots.Dataaremean±standarddeviation(SD).*P
2). Microgravity-Induced Cognitive Decline: Investigating the Pathogenic Mechanisms of RyR2 Hyperphosphorylation and S107 Intervention. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2025 (PubMed: 40577051) [IF=4.4]
3). Fibroblast Growth Factor Receptor 4 Promotes Triple-Negative Breast Cancer Progression via Regulating Fatty Acid Metabolism Through the AKT/RYR2 Signaling. Cancer medicine, 2024 (PubMed: 39658878) [IF=2.9]

Application: WB    Species: human    Sample:

FIGURE 5 FGFR4 regulates TNBC progression through the AKT/RYR2 axis. (A) Western blotting was performed after FGFR4 inhibition in TNBC cell lines. (B) The Western blotting bands were quantified by ImageJ software. (C) The mRNA levels of lipid metabolism-related genes were determined by qRT-PCR after FGFR4 inhibition alone or combined with SC79 in TNBC cell lines. (D) Represent image of colony formation assay after treatment. (E) Colony formation number was quantified by ImageJ software. (F) Represent image of Transwell assay after treatment (left). Invasive cell number was quantified (right). (G) Represent image of Oil red O staining after treatment. (H) Intracellular lipid droplet contents were quantified by ImageJ software. (I) Represent image of JC-1 staining for MMP measurement after treatment (left). MMP level was quantified (right). *p 
4). Evodiamine protects against cardiac remodeling in heart failure through modulation of calcium signaling and CD47. Biochemical and biophysical research communications, 2025 (PubMed: 40609209) [IF=2.5]

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