Phospho-Caveolin 1 (Tyr14) Antibody - #AF3386

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产品: 磷酸化 Caveolin 1 (Tyr14) 抗体
货号: AF3386
描述: Rabbit polyclonal antibody to Phospho-Caveolin 1 (Tyr14)
应用: WB IF/ICC
文献验证: WB, IF/ICC
反应: Human, Mouse, Rat
预测: Pig, Bovine, Horse, Sheep, Rabbit, Dog
蛋白号: Q03135
RRID: AB_2834817

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 50ul RMB¥ 1300 现货
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 200ul RMB¥ 3200 现货

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实验方案
WB Handbook
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IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
Phospho-Caveolin 1 (Tyr14) Antibody detects endogenous levels of Caveolin 1 only when phosphorylated at Tyrosine 14.
RRID:
AB_2834817
引用格式: Affinity Biosciences Cat# AF3386, RRID:AB_2834817.
偶联:
Unconjugated.
纯化:
The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

BSCL3; CAV; CAV1; CAV1_HUMAN; caveolae protein, 22 kD; caveolin 1 alpha isoform; caveolin 1 beta isoform; Caveolin 1 caveolae protein 22kDa; Caveolin-1; Caveolin1; cell growth-inhibiting protein 32; CGL3; LCCNS; MSTP085; OTTHUMP00000025031; PPH3; VIP 21; VIP21;

抗原和靶标

免疫原:

A synthesized peptide derived from human Caveolin 1 around the phosphorylation site of Tyr14.

基因/基因ID:
CAV1(857)
描述:
caveolin-1 May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Involved in the costimulatory signal essential for T-cell receptor (TCR)- mediated T-cell activation.

研究领域

· Cellular Processes > Transport and catabolism > Endocytosis.   (View pathway)

· Cellular Processes > Cellular community - eukaryotes > Focal adhesion.   (View pathway)

· Human Diseases > Infectious diseases: Bacterial > Bacterial invasion of epithelial cells.

· Human Diseases > Cancers: Overview > Proteoglycans in cancer.

· Human Diseases > Cardiovascular diseases > Viral myocarditis.

文献引用

1). The purified extract of steamed Panax ginseng protects cardiomyocyte from ischemic injury via caveolin-1 phosphorylation-mediating calcium influx. Journal of Ginseng Research, 2023 (PubMed: 38107394) [IF=6.8]

Application: IF/ICC    Species: Rat    Sample:

EPG inhibited apoptosis and decreased STIM via p-caveolin-1 against MI injury in myocardium of rats (n = 4-6/group). (A) TUNEL staining, apoptotic nuclei (green) and DAPI-positive normal nuclei (blue). (B) Immuno-histochemical staining of p-caveolin-1 and STIM1. (C) Apoptotic rate (%). (D, E) Quantitative mean fluorescence intensity (MFI). ###P < 0.001 vs. sham, ∗∗∗P < 0.001 vs. model, & P < 0.05, &&&P < 0.001 vs. EPG.

Application: WB    Species: Rat    Sample:

Fig. 5 P-Caveolin-1/SOCE pathway mediated EPG-induced protection against MI injury in rats (n = 4-6/group). (A) Western blot bands. Quantitative analysis of protein expression (B–F) and mRNA expression (G-J).
2). Irisin alleviates steroid-induced vascular dysfunction by regulating the αVβ5-c-Abl-Caveolin-1 signaling pathway. Biochemical pharmacology, 2025 (PubMed: 40086515) [IF=5.3]
3). Daidzein alleviates osteoporosis by promoting osteogenesis and angiogenesis coupling. PeerJ, 2023 (PubMed: 37868048) [IF=2.3]

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