URAT1 Antibody - #DF12340

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产品: URAT1 抗体
货号: DF12340
描述: Rabbit polyclonal antibody to URAT1
应用: WB IHC
文献验证: WB
反应: Human, Mouse, Rat, Pig, Monkey
预测: Pig, Horse
蛋白号: Q96S37
RRID: AB_2845145

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat, Pig, Monkey
克隆:
Polyclonal
特异性:
URAT1 Antibody detects endogenous levels of total URAT1.
RRID:
AB_2845145
引用格式: Affinity Biosciences Cat# DF12340, RRID:AB_2845145.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Organic anion transporter 4-like protein; Renal-specific transporter; RST; S22AC_HUMAN; Slc22a12; Solute carrier family 22 member 12; Urate anion exchanger 1;

抗原和靶标

免疫原:

A synthesized peptide derived from human URAT1, corresponding to a region within N-terminal amino acids.

基因/基因ID:
SLC22A12(116085)

文献引用

1). Caffeic acid phenethyl ester alleviated hypouricemia in hyperuricemic mice through inhibiting XOD and up-regulating OAT3. PHYTOMEDICINE, 2022 (PubMed: 35714456) [IF=6.7]
2). The Extract of Sonneratia apetala Leaves and Branches Ameliorates Hyperuricemia in Mice by Regulating Renal Uric Acid Transporters and Suppressing the Activation of the JAK/STAT Signaling Pathway. Frontiers in Pharmacology, 2021 (PubMed: 34483901) [IF=5.6]

Application: WB    Species: Mice    Sample: kidney tissues

FIGURE 10 Effects of SAL on the expression of uric acid transporters. (A) The expression levels of the URAT1, GLUT9, and OAT1; quantitative results of Western blot analyses for (B) GLUT9; (C) URAT1; (D) OAT1. β-actin was used as a loading control. All data are expressed as mean ± SD (n = 3). ## p < 0.01 vs. the intact group, **p < 0.01 vs. the vehicle group.
3). Sonneratia apetala seed oil attenuates potassium oxonate/hypoxanthine-induced hyperuricemia and renal injury in mice. Food & Function, 2021 (PubMed: 34606558) [IF=5.1]
4). Uric acid accumulation in the kidney triggers mast cell degranulation and aggravates renal oxidative stress. Toxicology, 2023 (PubMed: 36464070) [IF=4.8]
5). Berberrubine attenuates potassium oxonate- and hypoxanthine-induced hyperuricemia by regulating urate transporters and JAK2/STAT3 signaling pathway. European Journal of Pharmacology, 2021 (PubMed: 34699754) [IF=4.2]
6). Lacticaseibacillus paracasei LT12—A Probiotic Strain That Reduces Hyperuricemia via Inhibiting XO Activity and Regulating Renal Uric Acid Transportation Protein. Fermentation, 2025 [IF=3.7]

Application: WB    Species: Mouse    Sample:

Figure 5. Regulation of renal uric acid transport proteins by L. paracasei LT12 in a hyperuricemia mouse model: URAT1 (a), OAT1 (b), GLUT9 (c), and ABCG2 (d). The t-test with post hoc Tukey revealed statistically significant differences between groups, as indicated by different letters assigned to each group. Treatments sharing the same letter are not significantly different.
7). Ethanol extract of Nepeta angustifoia C. Y. Wu ameliorates hyperuricemia in fructose-induced mice. Pakistan journal of pharmaceutical sciences, 2022 (PubMed: 36008897) [IF=0.7]
8). Naringenin Attenuates Gout-Induced Renal Injury in Rats Via TLR4/NLRP3 Pathway and Urate Transporters. , 2023
9). 基于病症模型的经方四妙丸防治高尿酸血症痛风的药效物质探讨.. Traditional Chinese Drug Research & Clinical Pharmacology, 2024
10). NRBP1 modulates uric acid transporter ABCG2 expression by activating the Wnt/β-catenin pathway in HK-2 cells. Nefrologia, 2023 (PubMed: 36437206)

Application: WB    Species: human    Sample: HK-2 cells

Fig. 2. Effect of NRBP1 overexpression and knockdown on the secretion and reabsorption of uric acid. A, Effect of NRBP1 overexpression and knockdown on the mRNA expression of NRBP1, ABCG2, OAT1, GLUT9 and URAT1. B, Effect of NRBP1 overexpression and knockdown on the protein expression of NRBP1, ABCG2, OAT1, GLUT9 and URAT1. ( n = 3), *P < 0.05, **P < 0.01 vs. Control group, #P < 0.05, ##P < 0.01 vs. Model group.

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