产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF12244, RRID:AB_2845049.
展开/折叠
ACAD 6; ACAD6; ACADV_HUMAN; Acadvl; Acyl CoA dehydrogenase very long chain; Acyl Coenzyme A dehydrogenase very long chain; LCACD; mitochondrial; Very long chain specific acyl CoA dehydrogenase; Very long chain specific acyl CoA dehydrogenase mitochondrial; Very long-chain specific acyl-CoA dehydrogenase; VLCAD;
抗原和靶标
- P49748 ACADV_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MQAARMAASLGRQLLRLGGGSSRLTALLGQPRPGPARRPYAGGAAQLALDKSDSHPSDALTRKKPAKAESKSFAVGMFKGQLTTDQVFPYPSVLNEEQTQFLKELVEPVSRFFEEVNDPAKNDALEMVEETTWQGLKELGAFGLQVPSELGGVGLCNTQYARLVEIVGMHDLGVGITLGAHQSIGFKGILLFGTKAQKEKYLPKLASGETVAAFCLTEPSSGSDAASIRTSAVPSPCGKYYTLNGSKLWISNGGLADIFTVFAKTPVTDPATGAVKEKITAFVVERGFGGITHGPPEKKMGIKASNTAEVFFDGVRVPSENVLGEVGSGFKVAMHILNNGRFGMAAALAGTMRGIIAKAVDHATNRTQFGEKIHNFGLIQEKLARMVMLQYVTESMAYMVSANMDQGATDFQIEAAISKIFGSEAAWKVTDECIQIMGGMGFMKEPGVERVLRDLRIFRIFEGTNDILRLFVALQGCMDKGKELSGLGSALKNPFGNAGLLLGEAGKQLRRRAGLGSGLSLSGLVHPELSRSGELAVRALEQFATVVEAKLIKHKKGIVNEQFLLQRLADGAIDLYAMVVVLSRASRSLSEGHPTAQHEKMLCDTWCIEAAARIREGMAALQSDPWQQELYRNFKSISKALVERGGVVTSNPLGF
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P49748 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S54 | Phosphorylation | Uniprot | |
| K71 | Acetylation | Uniprot | |
| K239 | Acetylation | Uniprot | |
| K247 | Methylation | Uniprot | |
| K276 | Acetylation | Uniprot | |
| K278 | Acetylation | Uniprot | |
| R286 | Methylation | Uniprot | |
| K298 | Acetylation | Uniprot | |
| K299 | Acetylation | Uniprot | |
| S328 | Phosphorylation | Uniprot | |
| K331 | Acetylation | Uniprot | |
| K372 | Acetylation | Uniprot | |
| K372 | Ubiquitination | Uniprot | |
| K482 | Acetylation | Uniprot | |
| S485 | Phosphorylation | Uniprot | |
| S489 | Phosphorylation | Uniprot | |
| K492 | Ubiquitination | Uniprot | |
| K507 | Acetylation | Uniprot | |
| K507 | Ubiquitination | Uniprot | |
| S517 | Phosphorylation | Uniprot | |
| S522 | Phosphorylation | Uniprot | |
| S586 | Phosphorylation | Uniprot | |
| Y631 | Phosphorylation | Uniprot | |
| K635 | Sumoylation | Uniprot | |
| K639 | Acetylation | Uniprot | |
| K639 | Ubiquitination | Uniprot | |
| R644 | Methylation | Uniprot |
研究背景
Active toward esters of long-chain and very long chain fatty acids such as palmitoyl-CoA, myristoyl-CoA and stearoyl-CoA. Can accommodate substrate acyl chain lengths as long as 24 carbons, but shows little activity for substrates of less than 12 carbons.
S-nitrosylation at Cys-237 in liver improves catalytic efficiency.
Mitochondrion inner membrane.
Homodimer.
Belongs to the acyl-CoA dehydrogenase family.
研究领域
· Metabolism > Lipid metabolism > Fatty acid degradation.
· Metabolism > Global and overview maps > Metabolic pathways.
· Metabolism > Global and overview maps > Fatty acid metabolism.
限制条款
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