产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF12232, RRID:AB_2845037.
展开/折叠
Signal recognition particle 68; Signal recognition particle 68 kDa; Signal recognition particle 68 kDa protein; signal recognition particle 68kD; Signal recognition particle 68kDa; signal recognition particle subunit SRP68; SRP 68; SRP68; SRP68_HUMAN;
抗原和靶标
- Q9UHB9 SRP68_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAAEKQVPGGGGGGGSGGGGGSGGGGSGGGRGAGGEENKENERPSAGSKANKEFGDSLSLEILQIIKESQQQHGLRHGDFQRYRGYCSRRQRRLRKTLNFKMGNRHKFTGKKVTEELLTDNRYLLLVLMDAERAWSYAMQLKQEANTEPRKRFHLLSRLRKAVKHAEELERLCESNRVDAKTKLEAQAYTAYLSGMLRFEHQEWKAAIEAFNKCKTIYEKLASAFTEEQAVLYNQRVEEISPNIRYCAYNIGDQSAINELMQMRLRSGGTEGLLAEKLEALITQTRAKQAATMSEVEWRGRTVPVKIDKVRIFLLGLADNEAAIVQAESEETKERLFESMLSECRDAIQVVREELKPDQKQRDYILEGEPGKVSNLQYLHSYLTYIKLSTAIKRNENMAKGLQRALLQQQPEDDSKRSPRPQDLIRLYDIILQNLVELLQLPGLEEDKAFQKEIGLKTLVFKAYRCFFIAQSYVLVKKWSEALVLYDRVLKYANEVNSDAGAFKNSLKDLPDVQELITQVRSEKCSLQAAAILDANDAHQTETSSSQVKDNKPLVERFETFCLDPSLVTKQANLVHFPPGFQPIPCKPLFFDLALNHVAFPPLEDKLEQKTKSGLTGYIKGIFGFRS
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q9UHB9 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K5 | Acetylation | Uniprot | |
| S16 | Phosphorylation | Uniprot | |
| S22 | Phosphorylation | Uniprot | |
| S27 | Phosphorylation | Uniprot | |
| R31 | Methylation | Uniprot | |
| K39 | Ubiquitination | Uniprot | |
| S48 | Phosphorylation | Uniprot | |
| K49 | Ubiquitination | Uniprot | |
| K52 | Ubiquitination | Uniprot | |
| K67 | Ubiquitination | Uniprot | |
| K112 | Ubiquitination | Uniprot | |
| K142 | Ubiquitination | Uniprot | |
| K164 | Ubiquitination | Uniprot | |
| K205 | Ubiquitination | Uniprot | |
| K220 | Ubiquitination | Uniprot | |
| S241 | Phosphorylation | Uniprot | |
| S267 | Phosphorylation | Uniprot | |
| T270 | Phosphorylation | Uniprot | |
| K277 | Ubiquitination | Uniprot | |
| K288 | Ubiquitination | Uniprot | |
| S294 | Phosphorylation | Uniprot | |
| K306 | Ubiquitination | Uniprot | |
| K333 | Ubiquitination | Uniprot | |
| S339 | Phosphorylation | Uniprot | |
| K360 | Ubiquitination | Uniprot | |
| Y364 | Phosphorylation | Uniprot | |
| K372 | Ubiquitination | Uniprot | |
| Y385 | Phosphorylation | Uniprot | |
| K400 | Ubiquitination | Uniprot | |
| K416 | Acetylation | Uniprot | |
| K416 | Ubiquitination | Uniprot | |
| K452 | Acetylation | Uniprot | |
| K452 | Ubiquitination | Uniprot | |
| K457 | Ubiquitination | Uniprot | |
| K491 | Ubiquitination | Uniprot | |
| K504 | Ubiquitination | Uniprot | |
| K508 | Ubiquitination | Uniprot | |
| T518 | Phosphorylation | Uniprot | |
| K524 | Ubiquitination | Uniprot | |
| T543 | Phosphorylation | Uniprot | |
| C562 | S-Nitrosylation | Uniprot | |
| T611 | Phosphorylation | Uniprot | |
| K612 | Ubiquitination | Uniprot | |
| Y618 | Phosphorylation | Uniprot | |
| S627 | Phosphorylation | Uniprot |
研究背景
Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP68 binds the 7S RNA, SRP72 binds to this complex subsequently. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function.
Cytoplasm. Nucleus>Nucleolus.
Signal recognition particle consists of a 7S RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.
The RNA-binding domain is located near the N-terminus.
Belongs to the SRP68 family.
研究领域
· Genetic Information Processing > Folding, sorting and degradation > Protein export.
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