FABP5 Antibody - #DF12115
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF12115, RRID:AB_2844920.
展开/折叠
CFABP; Cutaneous fatty acid binding protein; DA11; Differentiation associated lipid binding protein LP2; E-FABP; EFABP; Epidermal-type fatty acid-binding protein; FABP5; FABP5_HUMAN; fatty acid binding protein 5 (psoriasis-associated); Fatty acid binding protein epidermal; Fatty acid-binding protein 5; Fatty acid-binding protein, epidermal; Keratinocyte lipid binding protein; KFABP; Klbp; mal1; PA-FABP; PAFABP; Psoriasis associated fatty acid binding protein homolog; Psoriasis-associated fatty acid-binding protein homolog;
抗原和靶标
- Q01469 FABP5_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MATVQQLEGRWRLVDSKGFDEYMKELGVGIALRKMGAMAKPDCIITCDGKNLTIKTESTLKTTQFSCTLGEKFEETTADGRKTQTVCNFTDGALVQHQEWDGKESTITRKLKDGKLVVECVMNNVTCTRIYEKVE
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q01469 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| R10 | Methylation | Uniprot | |
| S16 | Phosphorylation | Uniprot | |
| K17 | Acetylation | Uniprot | |
| K17 | Ubiquitination | Uniprot | |
| Y22 | Phosphorylation | Uniprot | |
| K24 | Methylation | Uniprot | |
| K24 | Ubiquitination | Uniprot | |
| K34 | Ubiquitination | Uniprot | |
| K40 | Acetylation | Uniprot | |
| K40 | Ubiquitination | Uniprot | |
| T46 | Phosphorylation | Uniprot | |
| K50 | Ubiquitination | Uniprot | |
| K55 | Acetylation | Uniprot | |
| K55 | Ubiquitination | Uniprot | |
| K61 | Acetylation | Uniprot | |
| K61 | Ubiquitination | Uniprot | |
| T63 | Phosphorylation | Uniprot | |
| C67 | S-Nitrosylation | Uniprot | |
| K72 | Acetylation | Uniprot | |
| K72 | Ubiquitination | Uniprot | |
| K82 | Ubiquitination | Uniprot | |
| K103 | Ubiquitination | Uniprot | |
| Y131 | Phosphorylation | Uniprot |
研究背景
Intracellular carrier for long-chain fatty acids and related active lipids, such as the endocannabinoid, that regulates the metabolism and actions of the ligands they bind. In addition to the cytosolic transport, selectively delivers specific fatty acids from the cytosol to the nucleus, wherein they activate nuclear receptors. Delivers retinoic acid to the nuclear receptor peroxisome proliferator-activated receptor delta; which promotes proliferation and survival. May also serve as a synaptic carrier of endocannabinoid at central synapses and thus controls retrograde endocannabinoid signaling. Modulates inflammation by regulating PTGES induction via NF-kappa-B activation, and prostaglandin E2 (PGE2) biosynthesis during inflammation (By similarity). May be involved in keratinocyte differentiation.
Cytoplasm. Nucleus. Cell junction>Synapse. Cell junction>Synapse>Postsynaptic density. Secreted.
Note: Localizes primarily to the cytoplasm. Upon certain ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into nucleus (PubMed:24692551). Secreted by astrocytes, but not by neurons (By similarity).
Keratinocytes; highly expressed in psoriatic skin.
Monomer. Homodimer.
Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.
Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
研究领域
· Organismal Systems > Endocrine system > PPAR signaling pathway.
限制条款
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