TMEM173/STING Antibody - #DF12090

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产品: TMEM173/STING 抗体
货号: DF12090
描述: Rabbit polyclonal antibody to TMEM173/STING
应用: WB IHC IF/ICC
文献验证: WB
反应: Human, Mouse, Rat
预测: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
蛋白号: Q86WV6
RRID: AB_2844895

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
TMEM173/STING Antibody detects endogenous levels of total TMEM173/STING.
RRID:
AB_2844895
引用格式: Affinity Biosciences Cat# DF12090, RRID:AB_2844895.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

endoplasmic reticulum IFN stimulator; Endoplasmic reticulum interferon stimulator; ERIS; FLJ38577; hMITA; hSTING; Mediator of IRF3 activation; MITA; Mitochondrial mediator of IRF3 activation; MPYS; N terminal methionine proline tyrosine serine plasma membrane tetraspanner; NET23; Stimulator of interferon genes; Stimulator of interferon genes protein; STING; TM173_HUMAN; Tmem173; Transmembrane protein 173;

抗原和靶标

免疫原:

A synthesized peptide derived from human TMEM173/STING, corresponding to a region within the internal amino acids.

基因/基因ID:
TMEM173(340061)

研究领域

· Organismal Systems > Immune system > NOD-like receptor signaling pathway.   (View pathway)

· Organismal Systems > Immune system > RIG-I-like receptor signaling pathway.   (View pathway)

· Organismal Systems > Immune system > Cytosolic DNA-sensing pathway.   (View pathway)

文献引用

1). Novel intravenous formulation for radiosensitization in osteosarcoma treatment. Materials today. Bio, 2025 (PubMed: 40206141) [IF=8.7]

Application: WB    Species: Mouse    Sample: K7M2 cells

Fig. 5. HPTM with NIR and RT induced accumulation of cytosolic DNA, activation of cGAS-STING and ICD. (A) Representative fluorescence images and (B) quantitative analysis of Picogreen(green) staining of K7M2 cells treated by different treatments, including HPTM, HP + NIR + RT, RT, HPTM + NIR, HPTM + RT, HPTM + NIR + RT. (C) Activation of cGAS-STING related protein was measured by Western Blot. (D) Cytokine levels of IFN-γ in K7M2 cells by ELISA on day 3 post various treatments. (E) Released ATP and (F) HMGB1 were quantified through ATP detection kits and ELISA kits, respectively. (G) Calreticulin immunofluorescence on the outer surface of K7M2RR cells was imaged by LSCM. All experiments were carried out with 3 biological replicates. # indicates a group which was compared with other groups. All values are the mean ± SD, n = 3. P values, ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001,∗∗∗∗p < 0.0001. ns, not significant.
2). Commensal cow Roseburia reduces gut-dysbiosis-induced mastitis through inhibiting bacterial translocation by producing butyrate in mice. Cell Reports, 2022 (PubMed: 36417859) [IF=7.5]
3). Lycopene Protects against Atrazine-Induced Kidney STING-Dependent PANoptosis through Stabilizing mtDNA via Interaction with Sam50/PHB1. Journal of agricultural and food chemistry, 2024 (PubMed: 38820047) [IF=5.7]
4). Hydrogen combined with needle-embedding therapy alleviates traumatic brain injury by inhibiting NLRP3 inflammasome activation via STING signaling pathway. Cytokine, 2025 (PubMed: 40187069) [IF=3.7]

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