Phospho-HDAC4 (Ser632) Antibody - #AF3349

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产品: 磷酸化 HDAC4 (Ser632) 抗体
货号: AF3349
描述: Rabbit polyclonal antibody to Phospho-HDAC4 (Ser632)
应用: WB IF/ICC
文献验证: WB
反应: Human, Mouse, Rat
预测: Pig, Zebrafish, Bovine, Sheep, Dog, Chicken, Xenopus
蛋白号: P56524
RRID: AB_2834764

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 50ul RMB¥ 1300 现货
 100ul RMB¥ 2400 现货
 200ul RMB¥ 3200 现货

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说明书
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实验方案
WB Handbook
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IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
Phospho-HDAC4 (Ser632) Antibody detects endogenous levels of HDAC4 only when phosphorylated at Serine 632.
RRID:
AB_2834764
引用格式: Affinity Biosciences Cat# AF3349, RRID:AB_2834764.
偶联:
Unconjugated.
纯化:
The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

AHO3; BDMR; EC 3.5.1.98; HA6116; HD 4; HD4; HDAC 4; HDAC A; HDAC4; HDAC4_HUMAN; HDACA; Histone deacetylase 4; Histone Deacetylase A; KIAA0288;

抗原和靶标

免疫原:

A synthesized peptide derived from human HDAC4 around the phosphorylation site of Ser632.

基因/基因ID:
HDAC4(9759)
描述:
HDAC4 a transcriptional regulator of the histone deacetylase family, subfamily 2. Deacetylates lysine residues on the N-terminal part of the core histones H2A, H2B, H3 AND H4.

研究领域

· Environmental Information Processing > Signal transduction > Apelin signaling pathway.   (View pathway)

· Human Diseases > Substance dependence > Alcoholism.

· Human Diseases > Infectious diseases: Viral > Human papillomavirus infection.

· Human Diseases > Infectious diseases: Viral > Epstein-Barr virus infection.

· Human Diseases > Cancers: Overview > Viral carcinogenesis.

· Human Diseases > Cancers: Overview > MicroRNAs in cancer.

文献引用

1). Interaction between A-kinase anchoring protein 5 and protein kinase A mediates CaMKII/HDAC signaling to inhibit cardiomyocyte hypertrophy after hypoxic reoxygenation. Cellular signalling, 2023 (PubMed: 36565899) [IF=4.4]

Application: WB    Species: Rat    Sample:

Fig. 2. AKAP5-mediated cardiomyocyte hypertrophy CaMKII/HDAC pathway. (A) Expression of CaMKII/HDAC and hypertrophy-related proteins after H/R and AKAP5 transfection; (B) Expression of CaMKII/HDAC proteins after H/R and siAKAP5 transfection and KN93(10 uM, 1 h) intervention. Analysis by one-way ANOVA, All data are presented as the means ± SD (n = 3). ***P < 0.001 and ****P < 0.0001 vs. the CON group; *P < 0.05, **P < 0.01 and ***P < 0.001 vs. the H/R group; **P < 0.01, ***P < 0.001 and ****P < 0.0001 vs. the H/R + siAKAP5 group. CON, normal control group; H/R, hypoxia-reoxygenation group; NC, empty vector group; siAKAP5, siRNA-AKAP5 transfection group; KN93, an inhibitor of calmodulin-dependent kinase type II; AKAP5, A-kinase anchoring protein 5; CaMKII, Ca2+/CaM-dependent protein kinase II; HDAC4 /5, Histone deacetylases 4/5; MEF2C, Myocyte enhancer factor 2C.

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