ATR Antibody - #AF4767

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产品: ATR 抗体
货号: AF4767
描述: Rabbit polyclonal antibody to ATR
应用: WB
文献验证: WB
反应: Human, Mouse
预测: Bovine, Sheep
蛋白号: Q13535
RRID: AB_2844760

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse
克隆:
Polyclonal
特异性:
ATR Antibody detects endogenous levels of total ATR.
RRID:
AB_2844760
引用格式: Affinity Biosciences Cat# AF4767, RRID:AB_2844760.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Ataxia telangiectasia and Rad3 related; Ataxia telangiectasia and Rad3-related protein; ATR; ATR_HUMAN; FCTCS; FRAP Related Protein 1; FRAP-related protein 1; FRP1; MEC1; MEC1 mitosis entry checkpoint 1 homolog; Protein kinase ATR; RAC3; Rad3 related protein; SCKL; SCKL1; Serine/threonine protein kinase ATR; Serine/threonine-protein kinase ATR;

抗原和靶标

免疫原:

A synthesized peptide derived from human ATR, corresponding to a region within the internal amino acids.

基因/基因ID:
ATR(545)

研究领域

· Cellular Processes > Cell growth and death > Cell cycle.   (View pathway)

· Cellular Processes > Cell growth and death > p53 signaling pathway.   (View pathway)

· Cellular Processes > Cell growth and death > Cellular senescence.   (View pathway)

· Genetic Information Processing > Replication and repair > Fanconi anemia pathway.

· Human Diseases > Infectious diseases: Viral > Human papillomavirus infection.

· Human Diseases > Infectious diseases: Viral > HTLV-I infection.

文献引用

1). Inhibition of checkpoint kinase prevents human oocyte apoptosis induced by chemotherapy and allows enhanced tumour chemotherapeutic efficacy. Human reproduction (Oxford, England), 2023 (PubMed: 37451671) [IF=6.0]

Application: WB    Species: human    Sample:

Figure 3.Cisplatin activates the CHEK-TAp63α pathway in human primordial follicles. (A) H&E staining of human foetal ovaries. (B) p53, p63, and p73 immunostaining in human foetal ovaries. (C) H&E staining of human foetal ovary treated with cisplatin and PBS (Con) and histograms showing analysis of the apoptosis ratio of primordial follicles. (D) Conformational change of TAp63α detected by SDS-PAGE. The original and shifted positions of TAp63α are indicated by black and red arrows, respectively. (E) ChIP analysis of cisplatin-treated human foetal ovaries was performed to interrogate the Puma and Noxa promoter regions with specific antibodies for IgG (control) and p63. (F) Western blots for the ATR/ATM-CHEK pathway. (G) H&E staining and the ratio of apoptotic primordial oocytes in human foetal ovaries treated with cisplatin alone or along with CHEK1 inhibitor (CK1) or CHEK2 inhibitor (CK2). Red arrows indicate healthy primordial follicles, and yellow arrows indicate apoptotic primordial follicles. (H) Analysis of apoptosis-related proteins (BAX, BCL2, γH2AX, NOXA, and PUMA) in each group. (I) H&E staining and the ratio of apoptotic primordial oocytes in each group of adult ovaries. Red arrows indicate healthy primordial follicles, and yellow arrows indicate apoptotic primordial follicles. (J) TUNEL staining of adult ovaries. Yellow arrows indicate apoptotic primordial follicles and red arrows indicate healthy primordial follicles. **P 
2). Fraxetin attenuates DNA damage and inflammation in cisplatin-induced nephrotoxicity via FoxO1 activation. International immunopharmacology, 2025 (PubMed: 39765000) [IF=5.6]

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