PP2A-alpha Antibody - #AF4753

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产品: PP2A-alpha 抗体
货号: AF4753
描述: Rabbit polyclonal antibody to PP2A-alpha
应用: WB
文献验证: WB
反应: Human, Mouse, Rat
预测: Pig, Zebrafish, Bovine, Horse, Rabbit, Chicken, Xenopus
蛋白号: P67775
RRID: AB_2844748

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
PP2A-alpha Antibody detects endogenous levels of total PP2A-alpha.
RRID:
AB_2844748
引用格式: Affinity Biosciences Cat# AF4753, RRID:AB_2844748.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

PP2A alpha; PP2A-alpha; PP2AA_HUMAN; PP2Aalpha; PP2Ac; PP2CA; PP2Calpha; PPP2CA; Protein phosphatase 2 (formerly 2A) catalytic subunit alpha isoform; Protein phosphatase 2 catalytic subunit alpha isoform; Protein phosphatase 2, catalytic subunit, alpha isozyme; Protein phosphatase 2A catalytic subunit, alpha isoform; Replication protein C; RP C; RP-C; RPC; Serine/threonine protein phosphatase 2A catalytic subunit alpha isoform; Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform;

抗原和靶标

免疫原:

A synthesized peptide derived from human PP2A-alpha, corresponding to a region within C-terminal amino acids.

基因/基因ID:
PPP2CA(5515)

研究领域

· Cellular Processes > Cell growth and death > Oocyte meiosis.   (View pathway)

· Cellular Processes > Transport and catabolism > Autophagy - other.   (View pathway)

· Cellular Processes > Transport and catabolism > Autophagy - animal.   (View pathway)

· Cellular Processes > Cellular community - eukaryotes > Tight junction.   (View pathway)

· Environmental Information Processing > Signal transduction > Sphingolipid signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > PI3K-Akt signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > AMPK signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > TGF-beta signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > Hippo signaling pathway.   (View pathway)

· Genetic Information Processing > Translation > mRNA surveillance pathway.

· Human Diseases > Infectious diseases: Parasitic > Chagas disease (American trypanosomiasis).

· Human Diseases > Infectious diseases: Viral > Hepatitis C.

· Human Diseases > Infectious diseases: Viral > Human papillomavirus infection.

· Organismal Systems > Circulatory system > Adrenergic signaling in cardiomyocytes.   (View pathway)

· Organismal Systems > Nervous system > Dopaminergic synapse.

· Organismal Systems > Nervous system > Long-term depression.

文献引用

1). The miR-345-3p/PPP2CA signaling axis promotes proliferation and invasion of breast cancer cells Get access Arrow. CARCINOGENESIS, 2022 (PubMed: 34922339) [IF=3.3]
2). Therapeutic Mechanism of Kai Xin San on Alzheimer’s Disease Based on Network Pharmacology and Experimental Validation. Chinese Journal of Integrative Medicine, 2022 (PubMed: 36474082) [IF=2.2]
3). Identification of Key Pathways and Targets of Kai Xin San in The Treatment of Alzheimer's Disease Based On a Network Pharmacology Approach and Experimental Validation. Research Square, 2021

Application: WB    Species: Rat    Sample:

Figure 9. Kai Xin San administration attenuated Aβ, p-Tau Ser404, GSK3β as well as CDK5 levels, and upregulated PP1 and PP2A levels in hippocampus of Aβ1-42 injection Rats. Compared with the Aβ1-42 group, the levels of Aβ, p-Tau Ser404, GSK3β, as well as CDK5 decreased markedly in KXS and DH groups. Whereas, the expressions of PP1 and PP2A were increased obviously in KXS and DH groups. No significant change was found in the relative expression of Tau in each group

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