产品: Parathyroid Hormone 抗体
货号: AF0234
描述: Rabbit polyclonal antibody to Parathyroid Hormone
应用: WB IF/ICC
反应: Human
预测: Pig, Bovine, Horse, Rabbit, Dog
分子量: 16kDa; 13kD(Calculated).
蛋白号: P01270
RRID: AB_2833409

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 50ul RMB¥ 1250 现货
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 200ul RMB¥ 3000 现货

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:3000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human
预测:
Pig(93%), Bovine(87%), Horse(93%), Rabbit(86%), Dog(80%)
克隆:
Polyclonal
特异性:
Parathyroid Hormone Antibody detects endogenous levels of total Parathyroid Hormone.
RRID:
AB_2833409
引用格式: Affinity Biosciences Cat# AF0234, RRID:AB_2833409.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

hPTH; Parathormone; Parathyrin; Parathyroid hormone 1; Parathyroid hormone; Prepro PTH; Preproparathyroid hormone; PTH; PTH1; PTH1 receptor; PTH1R; PTHR; PTHR1; PTHY_HUMAN;

抗原和靶标

免疫原:
Uniprot:
基因/基因ID:
描述:
PTH PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Belongs to the parathyroid hormone family.
序列:
MIPAKDMAKVMIVMLAICFLTKSDGKSVKKRSVSEIQLMHNLGKHLNSMERVEWLRKKLQDVHNFVALGAPLAPRDAGSQRPRKKEDNVLVESHEKSLGEADKADVNVLTKAKSQ

种属预测

种属预测:

score>80的预测可信度较高,可尝试用于WB检测。*预测模型主要基于免疫原序列比对,结果仅作参考,不作为质保凭据。

Species
Results
Score
Pig
93
Horse
93
Bovine
87
Rabbit
86
Dog
80
Sheep
73
Chicken
73
Xenopus
0
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - P01270 作为底物

Site PTM Type Enzyme
T21 Phosphorylation
S23 Phosphorylation
S32 Phosphorylation
S34 Phosphorylation
S48 Phosphorylation

研究背景

功能:

PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells.

细胞定位:

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
亚基结构:

Interacts with PTH1R (via N-terminal extracellular domain).

蛋白家族:

Belongs to the parathyroid hormone family.

文献引用

1). Design, semi-synthesis and bioactivity evaluation of novel podophyllotoxin derivatives as potent anti-tumor agents. Bioorganic Chemistry (PubMed: 35661529) [IF=5.1]

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