Bcl-2 Antibody - #AF4700

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产品: Bcl-2 抗体
货号: AF4700
描述: Rabbit polyclonal antibody to Bcl-2
应用: WB
文献验证: WB
反应: Human
预测: Pig, Bovine
蛋白号: P10415
RRID: AB_2844705

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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实验方案
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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human
克隆:
Polyclonal
特异性:
Bcl-2 Antibody detects endogenous levels of total Bcl-2.
RRID:
AB_2844705
引用格式: Affinity Biosciences Cat# AF4700, RRID:AB_2844705.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Apoptosis regulator Bcl 2; Apoptosis regulator Bcl-2; Apoptosis regulator Bcl2; AW986256; B cell CLL/lymphoma 2; B cell leukemia/lymphoma 2; Bcl-2; Bcl2; BCL2_HUMAN; C430015F12Rik; D630044D05Rik; D830018M01Rik; Leukemia/lymphoma, B-cell, 2; Oncogene B-cell leukemia 2; PPP1R50; Protein phosphatase 1, regulatory subunit 50;

抗原和靶标

免疫原:

A synthesized peptide derived from human Bcl-2, corresponding to a region within the internal amino acids.

基因/基因ID:
BCL2(596)

研究领域

· Cellular Processes > Transport and catabolism > Autophagy - animal.   (View pathway)

· Cellular Processes > Cell growth and death > Apoptosis.   (View pathway)

· Cellular Processes > Cell growth and death > Apoptosis - multiple species.   (View pathway)

· Cellular Processes > Cell growth and death > Necroptosis.   (View pathway)

· Cellular Processes > Cellular community - eukaryotes > Focal adhesion.   (View pathway)

· Environmental Information Processing > Signal transduction > NF-kappa B signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > HIF-1 signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > Sphingolipid signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > PI3K-Akt signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > Hedgehog signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > Jak-STAT signaling pathway.   (View pathway)

· Genetic Information Processing > Folding, sorting and degradation > Protein processing in endoplasmic reticulum.   (View pathway)

· Human Diseases > Drug resistance: Antineoplastic > EGFR tyrosine kinase inhibitor resistance.

· Human Diseases > Drug resistance: Antineoplastic > Endocrine resistance.

· Human Diseases > Drug resistance: Antineoplastic > Platinum drug resistance.

· Human Diseases > Neurodegenerative diseases > Amyotrophic lateral sclerosis (ALS).

· Human Diseases > Infectious diseases: Parasitic > Toxoplasmosis.

· Human Diseases > Infectious diseases: Bacterial > Tuberculosis.

· Human Diseases > Infectious diseases: Viral > Hepatitis B.

· Human Diseases > Infectious diseases: Viral > Epstein-Barr virus infection.

· Human Diseases > Cancers: Overview > Pathways in cancer.   (View pathway)

· Human Diseases > Cancers: Overview > MicroRNAs in cancer.

· Human Diseases > Cancers: Specific types > Colorectal cancer.   (View pathway)

· Human Diseases > Cancers: Specific types > Prostate cancer.   (View pathway)

· Human Diseases > Cancers: Specific types > Small cell lung cancer.   (View pathway)

· Human Diseases > Cancers: Specific types > Gastric cancer.   (View pathway)

· Organismal Systems > Circulatory system > Adrenergic signaling in cardiomyocytes.   (View pathway)

· Organismal Systems > Immune system > NOD-like receptor signaling pathway.   (View pathway)

· Organismal Systems > Nervous system > Neurotrophin signaling pathway.   (View pathway)

· Organismal Systems > Nervous system > Cholinergic synapse.

· Organismal Systems > Endocrine system > Estrogen signaling pathway.   (View pathway)

文献引用

1). Self-activated arsenic manganite nanohybrids for visible and synergistic thermo/immuno-arsenotherapy. Journal of Controlled Release, 2022 (PubMed: 36063961) [IF=10.5]
2). Downregulation of the Long Noncoding RNA IALNCR Targeting MAPK8/JNK1 Promotes Apoptosis and Antagonizes Bovine Viral Diarrhea Virus Replication in Host Cells. Journal of Virology, 2022 (PubMed: 35993735) [IF=4.0]

Application: WB    Species: Bovine    Sample: MDBK cells and BT cell

FIG 3 mRNA levels of apoptosis-related genes caspase-3 and Bcl-2 (A), and Bax and Bak1 (B) detected by qRT-PCR at different time points after BVDV infection (*, P < 0.05; **, P < 0.01; ***, P < 0.001). (C) Protein levels of caspase-3 and Bcl-2 were detected by Western blotting at different time points after BVDV infection. Lowercase letters (a versus b; b versus c) indicate a significant difference of P < 0.05; a versus c indicates a significant difference of P < 0.01. (D) Protein levels of apoptosis-related pathway proteins were detected by Western blotting (***, P < 0.001). (E) Identification of procaspase-3/8/9 cleavage, ICAD/DFF45 degradation, nuclear translocation of active caspase-3 and CAD/DFF40, and nuclear PARP cleavage by Western blotting in BVDV-infected MDBK cells and BT cells at different time points after infection.
3). 前列腺素D2对山羊黄体细胞内分泌功能及其凋亡相关基因表达的影响. , 2023
4). Effect of Prostaglandin D2 on Endocrine Function and Expression of Apoptosis-related Genes in Goat Luteal Cells. 畜牧兽医学报, 2023

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