NLRP3 Antibody - #AF4620

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产品: NLRP3 抗体
货号: AF4620
描述: Rabbit polyclonal antibody to NLRP3
应用: WB
文献验证: WB
反应: Human, Mouse
预测: Pig, Bovine, Horse, Sheep, Dog
蛋白号: Q96P20
RRID: AB_2844567

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse
克隆:
Polyclonal
特异性:
NLRP3 Antibody detects endogenous levels of total NLRP3.
RRID:
AB_2844567
引用格式: Affinity Biosciences Cat# AF4620, RRID:AB_2844567.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

AGTAVPRL; AII/AVP; Angiotensin/vasopressin receptor AII/AVP like; Angiotensin/vasopressin receptor AII/AVP-like; C1orf7; Caterpiller protein 1.1; CIAS 1; CIAS1; CLR1.1; Cold autoinflammatory syndrome 1; Cold autoinflammatory syndrome 1 protein; Cryopyrin; Familial cold autoinflammatory syndrome; FCAS; FCU; LRR and PYD domains-containing protein 3; Muckle-Wells syndrome; MWS; NACHT; NACHT LRR and PYD containing protein 3; NALP 3; NALP3; NALP3_HUMAN; NLR family pyrin domain containing 3; NLRP3; PYPAF 1; PYPAF1; PYRIN containing APAF1 like protein 1; PYRIN-containing APAF1-like protein 1;

抗原和靶标

免疫原:

A synthesized peptide derived from human NLRP3, corresponding to a region within the internal amino acids.

基因/基因ID:
NLRP3(114548)

研究领域

· Cellular Processes > Cell growth and death > Necroptosis.   (View pathway)

· Human Diseases > Infectious diseases: Bacterial > Pertussis.

· Human Diseases > Infectious diseases: Viral > Influenza A.

· Organismal Systems > Immune system > NOD-like receptor signaling pathway.   (View pathway)

文献引用

1). Knocking down TRPM2 expression reduces cell injury and NLRP3 inflammasome activation in PC12 cells subjected to oxygen-glucose deprivation. Neural Regeneration Research, 2020 (PubMed: 32394974) [IF=5.9]

Application: WB    Species:    Sample:

Figure 6 |TRPM2-shRNA-1 reduces OGD-induced expression of NLRP3,CXCL2, and caspase-1.(A)NLRP3 (NLRP3/β-actin), CXCL2 (CXCL2/β-actin), and caspase-1(caspase-1/β-actin) mRNA expression(as determined by fluorescence-based quantitative reverse transcription-polymerase chain reaction). (B) NLRP3, CXCL2, and caspase-1 protein expression (as determined by western blotting). Data are expressed as the mean ±standard deviation (SD) (n = 6; one-way analysis of variance followed by Student-Newman-Keuls post hoc test). *P< 0.05, vs. shRNA-NC group; #P < 0.05,vs. shRNA-NC + OGD group. CXCL2:chemokine ligand-2; NC: normal control; NLRP3: NACHT, LRR and PYD domains-containing protein 3; OGD:oxygen-glucose deprivation; TRPM2:transient receptor potential melastatin 2.
2). Tracheal epithelial cell-exosome-derived MiR-21-5p inhibits alveolar macrophage pyroptosis to resist pulmonary bacterial infection through PIK3CD-autophagy pathway. Life sciences, 2024 (PubMed: 38092143) [IF=5.2]
3). Inflammatory suppression and immunity regulation benefits of honokiol in a rat model of acute peritonitis via the regulation of NLRP3 inflammasome and Sirt1/autophagy axis. Histology and histopathology, 2024 (PubMed: 38112214) [IF=2.5]

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