Phospho-RIPK3 (Ser316) Antibody - #AF4508

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产品: 磷酸化 RIPK3 (Ser316) 抗体
货号: AF4508
描述: Rabbit polyclonal antibody to Phospho-RIPK3 (Ser316)
应用: WB
文献验证: WB
反应: Human
蛋白号: Q9Y572
RRID: AB_2844557

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   规格 价格 库存
 50ul RMB¥ 1500 现货
 100ul RMB¥ 2800 现货
 200ul RMB¥ 3800 现货

货期: 当天发货

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human
克隆:
Polyclonal
特异性:
Phospho-RIPK3 (Ser316) Antibody detects endogenous levels of RIPK3 only when phosphorylated at Ser316.
RRID:
AB_2844557
引用格式: Affinity Biosciences Cat# AF4508, RRID:AB_2844557.
偶联:
Unconjugated.
纯化:
The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Receptor interacting protein 3; Receptor interacting serine threonine kinase 3; Receptor interacting serine/threonine protein kinase 3; Receptor-interacting protein 3; Receptor-interacting serine/threonine-protein kinase 3; RIP 3; RIP like protein kinase 3; RIP-3; RIP-like protein kinase 3; RIPK 3; RIPK3; RIPK3_HUMAN;

抗原和靶标

免疫原:

A synthesized peptide derived from human RIPK3 around the phosphorylation site of Ser316.

基因/基因ID:
RIPK3(11035)

研究领域

· Cellular Processes > Cell growth and death > Necroptosis.   (View pathway)

· Environmental Information Processing > Signal transduction > TNF signaling pathway.   (View pathway)

· Organismal Systems > Immune system > NOD-like receptor signaling pathway.   (View pathway)

· Organismal Systems > Immune system > Cytosolic DNA-sensing pathway.   (View pathway)

文献引用

1). LncRNA EMBP1 sponges miR-454-3p to upregulate IRF1 and activate NLRP3-mediated chondrocyte pyroptosis to drive osteoarthritis progression. International immunopharmacology, 2025 (PubMed: 40112602) [IF=4.8]

Application: WB    Species: human    Sample:

Fig. 6. The expression of the hub gene IRF1 and PANoptosis-related pyroptosis, necrosis, and apoptosis proteins is elevated in clinical OA cartilage samples. (A) Clinical cartilage samples used in this study, with Grade 0–1 cartilage as the control group (green arrow) and Grade 3–4 cartilage as the OA group (red arrow).(B) Western Blot was used to examine the expression of the hub gene IRF1 and PANoptosis-related proteins in cartilage tissue, including pyroptosis markers (NLRP3 and GSDMD-N), necrosis markers (p-RIP3 and p-MLKL), and apoptosis markers (cleaved-Caspase-8 and cleaved-Caspase-3) in the OA and control groups. (Csingle bondI) Quantitative analysis of Western Blot results. All data are presented as mean ± S.D. (n = 3). ⁎⁎P < 0.01, ⁎P < 0.05. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)

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