Phospho-CD32 (Tyr288) Antibody - #AF4348
| 产品: | 磷酸化 CD32 (Tyr288) 抗体 |
| 货号: | AF4348 |
| 描述: | Rabbit polyclonal antibody to Phospho-CD32 (Tyr288) |
| 应用: | WB IHC |
| 反应: | Human, Rat |
| 分子量: | 40kDa,44 kDa; 35kD(Calculated). |
| 蛋白号: | P12318 |
| RRID: | AB_2844427 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF4348, RRID:AB_2844427.
展开/折叠
CD32; CD32 antigen; CDw32; Fc fragment of IgG, low affinity IIa, receptor (CD32); Fc fragment of IgG, low affinity IIa, receptor for (CD32); Fc gamma RII a; Fc gamma RIIa; Fc-gamma RII-a; Fc-gamma-RIIa; FCG2; FCG2A_HUMAN; FcGR; FCGR2; FCGR2A; FCGR2A1; FcRII a; FcRII-a; IGFR2; IgG Fc receptor II a; IgG Fc receptor II-a; Immunoglobulin G Fc receptor II; low affinity immunoglobulin gamma Fc region receptor II a; Low affinity immunoglobulin gamma Fc region receptor II-a;
抗原和靶标
- P12318 FCG2A_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MTMETQMSQNVCPRNLWLLQPLTVLLLLASADSQAAAPPKAVLKLEPPWINVLQEDSVTLTCQGARSPESDSIQWFHNGNLIPTHTQPSYRFKANNNDSGEYTCQTGQTSLSDPVHLTVLSEWLVLQTPHLEFQEGETIMLRCHSWKDKPLVKVTFFQNGKSQKFSHLDPTFSIPQANHSHSGDYHCTGNIGYTLFSSKPVTITVQVPSMGSSSPMGIIVAVVIATAVAAIVAAVVALIYCRKKRISANSTDPVKAAQFEPPGRQMIAIRKRQLEETNNDYETADGGYMTLNPRAPTDDDKNIYLTLPPNDHVNSNN
翻译修饰 - P12318 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| N97 | N-Glycosylation | Uniprot | |
| N178 | N-Glycosylation | Uniprot | |
| Y240 | Phosphorylation | Uniprot | |
| K255 | Ubiquitination | Uniprot | |
| K271 | Acetylation | Uniprot | |
| T277 | Phosphorylation | Uniprot | |
| Y281 | Phosphorylation | P51451 (BLK) , P43405 (SYK) , P07948 (LYN) , P06241 (FYN) | Uniprot |
| T283 | Phosphorylation | Uniprot | |
| Y288 | Phosphorylation | P07948 (LYN) , P43405 (SYK) , P51451 (BLK) , P06241 (FYN) | Uniprot |
| T290 | Phosphorylation | Uniprot | |
| T297 | Phosphorylation | Uniprot | |
| Y304 | Phosphorylation | P43405 (SYK) , P06241 (FYN) , P07948 (LYN) , P51451 (BLK) | Uniprot |
研究背景
Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens.
Phosphorylated by SRC-type Tyr-kinases such as LYN, BLK, FYN, HCK and SYK.
Cell membrane>Single-pass type I membrane protein.
Found on monocytes, neutrophils and eosinophil platelets.
Interacts with INPP5D/SHIP1 and INPPL1/SHIP2, regulating its function. Interacts with APCS and FGR. Interacts with HCK.
研究领域
· Cellular Processes > Transport and catabolism > Phagosome. (View pathway)
· Human Diseases > Infectious diseases: Parasitic > Leishmaniasis.
· Human Diseases > Infectious diseases: Bacterial > Staphylococcus aureus infection.
· Human Diseases > Infectious diseases: Bacterial > Tuberculosis.
· Human Diseases > Immune diseases > Systemic lupus erythematosus.
· Organismal Systems > Development > Osteoclast differentiation. (View pathway)
· Organismal Systems > Immune system > Platelet activation. (View pathway)
· Organismal Systems > Immune system > Fc gamma R-mediated phagocytosis. (View pathway)
限制条款
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