Phospho-STAT3 (Tyr705) Antibody - #AF3295

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产品: 磷酸化 STAT3 (Tyr705) 抗体
货号: AF3295
描述: Rabbit polyclonal antibody to Phospho-STAT3 (Tyr705)
应用: WB IHC IF/ICC IP
文献验证: WB
反应: Human, Mouse, Rat
预测: Pig, Bovine, Horse, Rabbit, Chicken
蛋白号: P40763
RRID: AB_2834714

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200, IP, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
Phospho-STAT3 (Tyr705) Antibody detects endogenous levels of STAT3 only when phosphorylated at Tyrosine 705.
RRID:
AB_2834714
引用格式: Affinity Biosciences Cat# AF3295, RRID:AB_2834714.
偶联:
Unconjugated.
纯化:
The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

1110034C02Rik; Acute Phase Response Factor; Acute-phase response factor; ADMIO; APRF; AW109958; DNA binding protein APRF; FLJ20882; HIES; MGC16063; Signal transducer and activator of transcription 3 (acute phase response factor); Signal transducer and activator of transcription 3; STAT 3; Stat3; STAT3_HUMAN;

抗原和靶标

免疫原:

A synthesized peptide derived from human STAT3 around the phosphorylation site of Tyr705.

基因/基因ID:
STAT3(6774)
描述:
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators.

研究领域

· Cellular Processes > Cell growth and death > Necroptosis.   (View pathway)

· Cellular Processes > Cellular community - eukaryotes > Signaling pathways regulating pluripotency of stem cells.   (View pathway)

· Environmental Information Processing > Signal transduction > HIF-1 signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > FoxO signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > Jak-STAT signaling pathway.   (View pathway)

· Human Diseases > Drug resistance: Antineoplastic > EGFR tyrosine kinase inhibitor resistance.

· Human Diseases > Endocrine and metabolic diseases > Insulin resistance.

· Human Diseases > Infectious diseases: Parasitic > Toxoplasmosis.

· Human Diseases > Infectious diseases: Viral > Hepatitis C.

· Human Diseases > Infectious diseases: Viral > Hepatitis B.

· Human Diseases > Infectious diseases: Viral > Measles.

· Human Diseases > Infectious diseases: Viral > Epstein-Barr virus infection.

· Human Diseases > Cancers: Overview > Pathways in cancer.   (View pathway)

· Human Diseases > Cancers: Overview > Viral carcinogenesis.

· Human Diseases > Cancers: Overview > Proteoglycans in cancer.

· Human Diseases > Cancers: Overview > MicroRNAs in cancer.

· Human Diseases > Cancers: Specific types > Pancreatic cancer.   (View pathway)

· Human Diseases > Cancers: Specific types > Acute myeloid leukemia.   (View pathway)

· Human Diseases > Cancers: Specific types > Non-small cell lung cancer.   (View pathway)

· Human Diseases > Immune diseases > Inflammatory bowel disease (IBD).

· Organismal Systems > Immune system > Chemokine signaling pathway.   (View pathway)

· Organismal Systems > Immune system > Th17 cell differentiation.   (View pathway)

· Organismal Systems > Endocrine system > Prolactin signaling pathway.   (View pathway)

· Organismal Systems > Endocrine system > Adipocytokine signaling pathway.

文献引用

1). Apoptotic vesicles resist oxidative damage in noise-induced hearing loss through activation of FOXO3a-SOD2 pathway. Stem cell research & therapy, 2023 (PubMed: 37061707) [IF=7.5]

Application: WB    Species: Mouse    Sample:

Fig. 7 STAT3 in apoVs may responsible for activating FOXO3a-SOD2 pathway. a, b, c western blotting examining the STAT3, SOD2, β-actin protein levels in UMSCs and apoVs (a), and statistical analysis (b, c). The level of SOD2 (b) and STAT3 (c) were relative to β-actin. N = 3 per group. d, e western blotting showing the STAT3, p-STAT3, β-actin levels in HEI-OC1 cells of each group (d), and statistical analysis (e, f). N = 4 per group. Data are presented as means ± SD. *p 
2). Leptin promotes angiogenesis via pericyte STAT3 pathway upon intracerebral hemorrhage. Cells, 2022 (PubMed: 36078162) [IF=6.0]
3). Leptin combined with withaferin A boost posthemorrhagic neurogenesis via activation of STAT3/SOCS3 pathway. Experimental neurology, 2024 (PubMed: 38714285) [IF=4.6]
4). Interleukin‑10 promotes proliferation and migration, and inhibits tendon differentiation via the JAK/Stat3 pathway in tendon‑derived stem cells in vitro. Molecular Medicine Reports, 2018 (PubMed: 30320384) [IF=3.4]
5). The capsaicinoid nonivamide suppresses the inflammatory response and attenuates the progression of steatosis in a NAFLD‐rat model. Journal of Biochemical and Molecular Toxicology, 2023 (PubMed: 36541345) [IF=3.2]
6). Interleukin-6 Promotes Proliferation but Inhibits Tenogenic Differentiation via the Janus Kinase/Signal Transducers and Activators of Transcription 3 (JAK/STAT3) Pathway in Tendon-Derived Stem Cells. MEDICAL SCIENCE MONITOR, 2018 (PubMed: 29547593) [IF=2.2]
7). Huang Gan Formula Eliminates the Oxidative Stress Effects of Advanced Oxidation Protein Products on the Divergent Regulation of the Expression of AGEs Receptors via the JAK2/STAT3 Pathway. Evidence-based Complementary and Alternative Medicine, 2017 (PubMed: 28465704)

Application: WB    Species: human    Sample:

Figure 6: Effects of AOPPs on JAK2 and STAT3 phosphorylation. Serum-starved HMCs were incubated with 200

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