LATS2 Antibody - #AF7940

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产品: LATS2 抗体
货号: AF7940
描述: Rabbit polyclonal antibody to LATS2
应用: WB
文献验证: WB
反应: Human, Mouse
预测: Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Xenopus
蛋白号: Q9NRM7
RRID: AB_2844303

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse
克隆:
Polyclonal
特异性:
LATS2 Antibody detects endogenous levels of total LATS2.
RRID:
AB_2844303
引用格式: Affinity Biosciences Cat# AF7940, RRID:AB_2844303.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

FLJ13161; Kinase phosphorylated during mitosis protein; KPM; Large tumor suppressor homolog 2; Large tumor suppressor homolog 2 Drosophila; Large tumor suppressor kinase 2; LATS large tumor suppressor Drosophila homolog 2; LATS large tumor suppressor homolog 2; Lats2; LATS2_HUMAN; Serine/threonine kinase kpm; Serine/threonine protein kinase kpm; Serine/threonine-protein kinase kpm; Serine/threonine-protein kinase LATS2; Warts like kinase; Warts-like kinase;

抗原和靶标

免疫原:

A synthesized peptide derived from human LATS2, corresponding to a region within the internal amino acids.

基因/基因ID:
LATS2(26524)

研究领域

· Environmental Information Processing > Signal transduction > Hippo signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > Hippo signaling pathway - multiple species.   (View pathway)

文献引用

1). LATS1 is a central signal transmitter for achieving full type-I interferon activity. Science Advances, 2022 (PubMed: 35394840) [IF=11.7]
2). Sophoridine inhibits lung cancer cell growth and enhances cisplatin sensitivity through activation of the p53 and Hippo signaling pathways. Gene, 2020 (PubMed: 32165304) [IF=2.6]

Application: WB    Species: human    Sample: NCI-H460、A549 cells and p53-deficient NCI-H1299 cells

Fig. 4.| Sophoridine activates the Hippo pathway and induces mRNA expression of Hippo downstream genes. a Sophoridine induced protein expression of core components of the Hippo pathway(MST1/2 and LATS1/2) and phosphorylated YAP and suppressed YAP protein and the Hippo target gene CTGF in NCI-H460 and A549 cells but not in p53-deficient NCI-H1299 cells. Cells were treated with DMSO or sophoridine (5 or 10 μg/mL) for 48 h.

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