Coagulation Factor III Antibody - #AF7723

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产品: Coagulation Factor III 抗体
货号: AF7723
描述: Rabbit polyclonal antibody to Coagulation Factor III
应用: WB IF/ICC
反应: Human, Mouse
预测: Pig, Bovine, Sheep
分子量: 33kDa, 50 kDa; 33kD(Calculated).
蛋白号: P13726
RRID: AB_2844087

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WB Handbook
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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse
预测:
Pig(88%), Bovine(86%), Sheep(86%)
克隆:
Polyclonal
特异性:
Coagulation Factor III Antibody detects endogenous levels of total Coagulation Factor III.
RRID:
AB_2844087
引用格式: Affinity Biosciences Cat# AF7723, RRID:AB_2844087.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

CD142; CD142 antigen; Coagulation factor III (thromboplastin tissue factor); Coagulation factor III; F3; FLJ17960; TF; TF_HUMAN; TFA; Thromboplastin; Tissue factor;

抗原和靶标

免疫原:
Uniprot:

P13726(TF_HUMAN) >>Visit HPA database.

基因/基因ID:
F3(2152)
表达:
P13726 TF_HUMAN:

Lung, placenta and pancreas.

序列:
METPAWPRVPRPETAVARTLLLGWVFAQVAGASGTTNTVAAYNLTWKSTNFKTILEWEPKPVNQVYTVQISTKSGDWKSKCFYTTDTECDLTDEIVKDVKQTYLARVFSYPAGNVESTGSAGEPLYENSPEFTPYLETNLGQPTIQSFEQVGTKVNVTVEDERTLVRRNNTFLSLRDVFGKDLIYTLYYWKSSSSGKKTAKTNTNEFLIDVDKGENYCFSVQAVIPSRTVNRKSTDSPVECMGQEKGEFREIFYIIGAVVFVVIILVIILAISLHKCRKAGVGQSWKENSPLNVS

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Pig
88
Bovine
86
Sheep
86
Rabbit
75
Dog
71
Horse
67
Xenopus
0
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - P13726 作为底物

Site PTM Type Enzyme
K100 Ubiquitination
S120 Phosphorylation
S285 Phosphorylation Q16539 (MAPK14) , P17252 (PRKCA)
K287 Methylation
K287 Ubiquitination
S290 Phosphorylation P17252 (PRKCA) , Q16539 (MAPK14)
S295 Phosphorylation

研究背景

功能:

Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.

细胞定位:

Membrane>Single-pass type I membrane protein.

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Lung, placenta and pancreas.

亚基结构:

Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII.

蛋白家族:

Belongs to the tissue factor family.

研究领域

· Organismal Systems > Immune system > Complement and coagulation cascades.   (View pathway)

文献引用

1). Colchicine inhibits the prothrombotic effects of oxLDL in human endothelial cells. VASCULAR PHARMACOLOGY (PubMed: 33232770) [IF=4.0]

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