TXN Antibody - #AF7577

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产品: TXN 抗体
货号: AF7577
描述: Rabbit polyclonal antibody to TXN
应用: WB
文献验证: WB
反应: Human, Mouse, Rat
预测: Pig, Bovine, Horse, Sheep, Rabbit
蛋白号: P10599
RRID: AB_2843941

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
TXN Antibody detects endogenous levels of total TXN.
RRID:
AB_2843941
引用格式: Affinity Biosciences Cat# AF7577, RRID:AB_2843941.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

ADF; ATL derived factor; ATL-derived factor; DKFZp686B1993; MGC61975; SASP; Surface associated sulphydryl protein; Surface-associated sulphydryl protein; testicular tissue protein Li 199; THIO_HUMAN; Thioredoxin; thioredoxin delta 3; TRDX; TRX 1; Trx; TRX1; TXN; TXN delta 3; TXN protein; zgc:92903;

抗原和靶标

免疫原:

A synthesized peptide derived from human TXN, corresponding to a region within C-terminal amino acids.

基因/基因ID:
TXN(7295)

研究领域

· Organismal Systems > Immune system > NOD-like receptor signaling pathway.   (View pathway)

文献引用

1). Irisin suppresses pancreatic β cell pyroptosis in T2DM by inhibiting the NLRP3-GSDMD pathway and activating the Nrf2-TrX/TXNIP signaling axis. Diabetology & metabolic syndrome, 2023 (PubMed: 37993958) [IF=4.8]

Application: WB    Species: Mouse    Sample: Min6 cells

Fig. 3 Irisin decreased oxidative stress levels and pyroptosis through activation of the Nrf2-TrX/TXNIP signaling axis The T2DM cell model was established via HG induction. Then, 100 ng/mL Irisin was added along with the Nrf2 inhibitor ML385, and the level of oxidative stress of cells in each group was evaluated (A: ROS, B: MDA, and C: SOD). (D) Pyroptosis was detected by GSDMD-N staining. (E) WB assays were performed to evaluate the level of expression of Nrf2 in the nucleus, as well as, the level of expression of TXNIP, TrX1, NLRP3, ASC, C-caspase-1, and GSDMD-N. (F) The protein expression levels were calculated as grayscale values. (G) Caspase-1 activity was assessed. ELISA was performed to assess the level of expression of IL-1β and IL-18 proteins (H) for elucidating the mechanism underlying the inhibition of oxidative stress and NLRP3-mediated pyroptosis by irisin. Scale bar = 130 μm

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