Phospho-TMEM173/STING (Ser366) Antibody - #AF7416

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产品: 磷酸化 TMEM173/STING (Ser366) 抗体
货号: AF7416
描述: Rabbit polyclonal antibody to Phospho-TMEM173/STING (Ser366)
应用: WB IHC IF/ICC
文献验证: WB, IF/ICC
反应: Human, Mouse, Rat
预测: Pig, Bovine, Horse, Sheep, Rabbit
蛋白号: Q86WV6
RRID: AB_2843856

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   规格 价格 库存
 100ul RMB¥ 2800 现货
 200ul RMB¥ 3800 现货

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
Phospho-TMEM173/STING (Ser366) Antibody detects endogenous levels of TMEM173/STING only when phosphorylated at Ser366.
RRID:
AB_2843856
引用格式: Affinity Biosciences Cat# AF7416, RRID:AB_2843856.
偶联:
Unconjugated.
纯化:
The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

endoplasmic reticulum IFN stimulator; Endoplasmic reticulum interferon stimulator; ERIS; FLJ38577; hMITA; hSTING; Mediator of IRF3 activation; MITA; Mitochondrial mediator of IRF3 activation; MPYS; N terminal methionine proline tyrosine serine plasma membrane tetraspanner; NET23; Stimulator of interferon genes; Stimulator of interferon genes protein; STING; TM173_HUMAN; Tmem173; Transmembrane protein 173;

抗原和靶标

免疫原:

A synthesized peptide derived from human TMEM173/STING around the phosphorylation site of Ser366.

基因/基因ID:
TMEM173(340061)

研究领域

· Organismal Systems > Immune system > NOD-like receptor signaling pathway.   (View pathway)

· Organismal Systems > Immune system > RIG-I-like receptor signaling pathway.   (View pathway)

· Organismal Systems > Immune system > Cytosolic DNA-sensing pathway.   (View pathway)

文献引用

1). Inhibiting Chemotherapy Immune Tolerance and Reversing Tumor Microenvironment by Macrophage-Targeted Nanohybrid Systems for Enhancing Tumor Chemo-Immunotherapy. ADVANCED FUNCTIONAL MATERIALS, 2025 [IF=18.5]
2). PARP Inhibition Induces Synthetic Lethality and Adaptive Immunity in LKB1-Mutant Lung Cancer. Cancer research, 2023 (PubMed: 36512628) [IF=12.5]
3). Manganese-doped liquid metal nanoplatforms for cellular uptake and glutathione depletion-enhanced photothermal and chemodynamic combination tumor therapy. Acta biomaterialia, 2025 (PubMed: 39522626) [IF=9.7]
4). Microglial double stranded DNA accumulation induced by DNase II deficiency drives neuroinflammation and neurodegeneration. Journal of neuroinflammation, 2025 (PubMed: 39833906) [IF=9.3]
5). Loss of Nrf2 aggravates ionizing radiation-induced intestinal injury by activating the cGAS/STING pathway via Pirin. Cancer letters, 2024 (PubMed: 39233044) [IF=9.1]
6). STING orchestrates microglia polarization via interaction with LC3 in autophagy after ischemia. Cell death & disease, 2024 (PubMed: 39537618) [IF=9.0]
7). Novel intravenous formulation for radiosensitization in osteosarcoma treatment. Materials today. Bio, 2025 (PubMed: 40206141) [IF=8.7]
8). IFI16 inhibits DNA repair that potentiates type-I interferon-induced antitumor effects in triple negative breast cancer. Cell Reports, 2021 (PubMed: 34936865) [IF=7.5]
9). STING promotes ferroptosis through NCOA4-dependent ferritinophagy in acute kidney injury. Free radical biology & medicine, 2023 (PubMed: 37634745) [IF=7.1]
10). Role of the cGAS-STING Pathway in Aging-related Endothelial Dysfunction. Aging and Disease, 2022 (PubMed: 36465181) [IF=7.0]

Application: WB    Species: Mouse    Sample:

Figure 1. Age-dependent changes in vasodilation function, and eNOS, p53, p21 p16 cGAS, STING and p-IRF3/IRF3 expression levels in mice. Acetylcholine (ACh)-induced relaxation (A) and sodium nitroprusside (SNP)-induced relaxation (B) of mouse aortas were measured in the 2 Months, 6 Months, 12 Months and 24 Months age groups. (C) The protein levels of eNOS, p53, p21, p16, cGAS, STING, p-IRF3, IRF3 and β-actin were measured in the aortas of mice in each age group by western blot analysis. β-actin was used as the housekeeper protein for normalization. Quantification of protein levels is shown in (D). Data were analyzed by (A and B) two-way ANOVA or (D) one way ANOVA plus Bonferroni post hoc test. All data shown are mean±SD. AU indicates arbitrary units. Relative expression is the fold changes relative to the 2 Months group. n=6, *P
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