产品: 磷酸化 SQSTM1/p62 (Ser366) 抗体
货号: AF7374
描述: Rabbit polyclonal antibody to Phospho-SQSTM1/p62 (Ser366)
应用: WB IHC
文献验证: WB
反应: Human, Mouse, Rat
预测: Pig, Bovine, Horse, Sheep, Rabbit
蛋白号: Q13501
RRID: AB_2843814

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 100ul RMB¥ 5800 现货

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
Phospho-SQSTM1/p62 (Ser366) Antibody detects endogenous levels of SQSTM1/p62 only when phosphorylated at Ser366.
RRID:
AB_2843814
引用格式: Affinity Biosciences Cat# AF7374, RRID:AB_2843814.
偶联:
Unconjugated.
纯化:
The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

A170; DMRV; EBI 3 associated protein of 60 kDa; EBI 3 associated protein p60; EBI3 associated protein of 60 kDa; EBI3 associated protein p60; EBI3-associated protein of 60 kDa; EBIAP; FTDALS3; MGC127197; ORCA; OSF-6; Osi; OSIL; Oxidative stress induced like; p60; p62; p62B; Paget disease of bone 3; PDB 3; PDB3; Phosphotyrosine independent ligand for the Lck SH2 domain of 62 kDa; Phosphotyrosine independent ligand for the Lck SH2 domain p62; Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa; PKC-zeta-interacting protein; Protein kinase C-zeta-interacting protein; Sequestosome 1; Sequestosome-1; SQSTM 1; SQSTM_HUMAN; Sqstm1; STAP; STONE14; Ubiquitin binding protein p62; Ubiquitin-binding protein p62; ZIP 3; ZIP; ZIP3;

抗原和靶标

免疫原:

A synthesized peptide derived from human SQSTM1/p62 around the phosphorylation site of Ser366.

基因/基因ID:

研究领域

· Cellular Processes > Cell growth and death > Necroptosis.   (View pathway)

· Cellular Processes > Cell growth and death > Cellular senescence.   (View pathway)

· Organismal Systems > Development > Osteoclast differentiation.   (View pathway)

文献引用

1). TBK1 Is a Synthetic Lethal Target in Cancer with VHL Loss. Cancer Discovery, 2020 (PubMed: 31810986) [IF=29.7]

Application: WB    Species: human    Sample: kidney cancer

Figure 6. TBK1 phosphorylates p62 on Ser366 and stabilize p62 in kidney cancer cells

2). BBOX1 restrains TBK1-mTORC1 oncogenic signaling in clear cell renal cell carcinoma. Nature communications, 2025 (PubMed: 39934163) [IF=16.6]

3). Kinome-wide siRNA screen identifies a DCLK2-TBK1 oncogenic signaling axis in clear cell renal cell carcinoma. Molecular cell, 2024 (PubMed: 38211588) [IF=14.5]

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