产品: | 磷酸化 CDK1/CDC2 (Thr14) 抗体 |
货号: | AF3236 |
描述: | Rabbit polyclonal antibody to Phospho-CDK1/CDC2 (Thr14) |
应用: | WB IF/ICC |
反应: | Human, Mouse, Rat |
预测: | Pig, Zebrafish, Bovine, Horse, Rabbit, Dog, Chicken, Xenopus |
分子量: | 34kDa; 34kD(Calculated). |
蛋白号: | P06493 |
RRID: | AB_2834662 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF3236, RRID:AB_2834662.
展开/折叠
Cdc2 related protein kinase; cdc2-related protein kinase; CDC28; CDC2A; Cdk 2; CDK1; CDK2; CDK2_HUMAN; CDKN2; Cell devision kinase 2; Cell division protein kinase 2; Cyclin dependent kinase 2; cyclin dependent kinase 2-alpha; Cyclin-dependent kinase 2; kinase Cdc2; MPF; p33 protein kinase; p33(CDK2);
抗原和靶标
- P06493 CDK1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM
种属预测
score>80的预测可信度较高,可尝试用于WB检测。*预测模型主要基于免疫原序列比对,结果仅作参考,不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P06493 作为底物
Site | PTM Type | Enzyme | Source |
---|---|---|---|
M1 | Acetylation | Uniprot | |
Y4 | Phosphorylation | P19525 (EIF2AK2) | Uniprot |
T5 | Phosphorylation | Uniprot | |
K6 | Acetylation | Uniprot | |
K6 | Sumoylation | Uniprot | |
K6 | Ubiquitination | Uniprot | |
K9 | Acetylation | Uniprot | |
K9 | Sumoylation | Uniprot | |
K9 | Ubiquitination | Uniprot | |
T14 | Phosphorylation | Q99640 (PKMYT1) | Uniprot |
Y15 | Phosphorylation | P12931 (SRC) , P30291 (WEE1) , Q99640 (PKMYT1) , P04626 (ERBB2) , P07948 (LYN) | Uniprot |
Y19 | Phosphorylation | Uniprot | |
K20 | Ubiquitination | Uniprot | |
K24 | Sumoylation | Uniprot | |
K24 | Ubiquitination | Uniprot | |
K33 | Acetylation | Uniprot | |
K33 | Sumoylation | Uniprot | |
K33 | Ubiquitination | Uniprot | |
K34 | Acetylation | Uniprot | |
K34 | Sumoylation | Uniprot | |
K34 | Ubiquitination | Uniprot | |
S39 | Phosphorylation | P68400 (CSNK2A1) | Uniprot |
S46 | Phosphorylation | Uniprot | |
S53 | Phosphorylation | Uniprot | |
K56 | Ubiquitination | Uniprot | |
Y77 | Phosphorylation | Uniprot | |
K89 | Ubiquitination | Uniprot | |
C119 | S-Nitrosylation | Uniprot | |
S121 | Phosphorylation | Uniprot | |
K130 | Sumoylation | Uniprot | |
K130 | Ubiquitination | Uniprot | |
K139 | Sumoylation | Uniprot | |
K139 | Ubiquitination | Uniprot | |
T141 | Phosphorylation | Uniprot | |
K143 | Ubiquitination | Uniprot | |
Y160 | Phosphorylation | Uniprot | |
T161 | Phosphorylation | P41279 (MAP3K8) , P50613 (CDK7) | Uniprot |
S171 | Phosphorylation | Uniprot | |
S178 | Phosphorylation | Uniprot | |
K201 | Sumoylation | Uniprot | |
K201 | Ubiquitination | Uniprot | |
S208 | Phosphorylation | O14757 (CHEK1) | Uniprot |
T222 | Phosphorylation | Uniprot | |
S233 | Phosphorylation | Uniprot | |
K238 | Sumoylation | Uniprot | |
K238 | Ubiquitination | Uniprot | |
T240 | Phosphorylation | Uniprot | |
K243 | Ubiquitination | Uniprot | |
K245 | Sumoylation | Uniprot | |
K245 | Ubiquitination | Uniprot | |
S248 | Phosphorylation | Uniprot | |
K254 | Sumoylation | Uniprot | |
K254 | Ubiquitination | Uniprot | |
S265 | Phosphorylation | Uniprot | |
K266 | Ubiquitination | Uniprot | |
Y270 | Phosphorylation | Uniprot | |
K274 | Ubiquitination | Uniprot | |
S277 | Phosphorylation | Uniprot | |
K279 | Sumoylation | Uniprot | |
K279 | Ubiquitination | Uniprot | |
Y286 | Phosphorylation | Uniprot | |
K295 | Sumoylation | Uniprot | |
K295 | Ubiquitination | Uniprot | |
K296 | Ubiquitination | Uniprot |
翻译修饰 - P06493 作为激酶
Substrate | Site | Source |
---|---|---|
A6NKT7 (RGPD3) | S1276 | Uniprot |
O00267 (SUPT5H) | S666 | Uniprot |
O00311 (CDC7) | T376 | Uniprot |
O00399 (DCTN6) | T186 | Uniprot |
O00418 (EEF2K) | S359 | Uniprot |
O00429 (DNM1L) | S616 | Uniprot |
O00443 (PIK3C2A) | S259 | Uniprot |
O00562 (PITPNM1) | T287 | Uniprot |
O00562 (PITPNM1) | S382 | Uniprot |
O00571 (DDX3X) | T204 | Uniprot |
O00571 (DDX3X) | T323 | Uniprot |
O14715 (RGPD8) | S1275 | Uniprot |
O14745 (SLC9A3R1) | S280 | Uniprot |
O14745 (SLC9A3R1) | S302 | Uniprot |
O14757 (CHEK1) | S286 | Uniprot |
O14757 (CHEK1) | S301 | Uniprot |
O14773 (TPP1) | T201 | Uniprot |
O14974 (PPP1R12A) | S432 | Uniprot |
O14974 (PPP1R12A) | S473 | Uniprot |
O14974 (PPP1R12A) | S601 | Uniprot |
O14980 (XPO1) | S391 | Uniprot |
O14994 (SYN3) | S470 | Uniprot |
O15151 (MDM4) | S96 | Uniprot |
O15287 (FANCG) | S383 | Uniprot |
O15287 (FANCG) | S387 | Uniprot |
O15287 (FANCG) | T487 | Uniprot |
O15350-1 (TP73) | T86 | Uniprot |
O15392 (BIRC5) | T34 | Uniprot |
O15446 (CD3EAP) | S285 | Uniprot |
O43521-2 (BCL2L11) | S44 | Uniprot |
O43663 (PRC1) | T481 | Uniprot |
O43683 (BUB1) | S593 | Uniprot |
O43683 (BUB1) | T609 | Uniprot |
O60331 (PIP5K1C) | S650 | Uniprot |
O60566 (BUB1B) | S543 | Uniprot |
O60566 (BUB1B) | T620 | Uniprot |
O60566 (BUB1B) | S670 | Uniprot |
O60566 (BUB1B) | S1043 | Uniprot |
O60610 (DIAPH1) | T768 | Uniprot |
O60701 (UGDH) | T461 | Uniprot |
O75122 (CLASP2) | S507 | Uniprot |
O75122 (CLASP2) | S541 | Uniprot |
O75152 (ZC3H11A) | T321 | Uniprot |
O75154 (RAB11FIP3) | S102 | Uniprot |
O94782 (USP1) | S313 | Uniprot |
O94916 (NFAT5) | T135 | Uniprot |
O95251 (KAT7) | T85 | Uniprot |
O95251 (KAT7) | T88 | Uniprot |
O95835-1 (LATS1) | T490 | Uniprot |
O95835 (LATS1) | S613 | Uniprot |
O95997 (PTTG1) | S165 | Uniprot |
P00338 (LDHA) | T248 | Uniprot |
P00519-1 (ABL1) | S569 | Uniprot |
P00519-2 (ABL1) | S588 | Uniprot |
P00533 (EGFR) | S1026 | Uniprot |
P02545-3 (LMNA) | T19 | Uniprot |
P02545-1 (LMNA) | S22 | Uniprot |
P02545 (LMNA) | S390 | Uniprot |
P02545 (LMNA) | S392 | Uniprot |
P04179 (SOD2) | S106 | Uniprot |
P04183 (TK1) | S13 | Uniprot |
P04637 (TP53) | S315 | Uniprot |
P05067 (APP) | T743 | Uniprot |
P05412 (JUN) | S63 | Uniprot |
P05412 (JUN) | S73 | Uniprot |
P05412 (JUN) | S243 | Uniprot |
P05783 (KRT18) | S34 | Uniprot |
P05787 (KRT8) | S432 | Uniprot |
P06400 (RB1) | S249 | Uniprot |
P06400 (RB1) | T252 | Uniprot |
P06400 (RB1) | T373 | Uniprot |
P06400 (RB1) | S807 | Uniprot |
P06400 (RB1) | S811 | Uniprot |
P06493-2 (CDK1) | Y19 | Uniprot |
P06748 (NPM1) | S70 | Uniprot |
P06748 (NPM1) | T199 | Uniprot |
P06748-2 (NPM1) | T205 | Uniprot |
P06748-2 (NPM1) | T208 | Uniprot |
P06748-1 (NPM1) | T219 | Uniprot |
P06748 (NPM1) | T234 | Uniprot |
P06748 (NPM1) | T237 | Uniprot |
P08047 (SP1) | T739 | Uniprot |
P08670 (VIM) | S55 | Uniprot |
P08670 (VIM) | S56 | Uniprot |
P0C1Z6 (TFPT) | S180 | Uniprot |
P10275 (AR) | S83 | Uniprot |
P10275 (AR) | S310 | Uniprot |
P10275 (AR) | S516 | Uniprot |
P10412 (HIST1H1E) | T18 | Uniprot |
P10415 (BCL2) | T56 | Uniprot |
P10415 (BCL2) | S70 | Uniprot |
P10636-6 (MAPT) | T95 | Uniprot |
P10636-8 (MAPT) | T153 | Uniprot |
P10636-8 (MAPT) | S202 | Uniprot |
P10636-8 (MAPT) | T205 | Uniprot |
P10636-8 (MAPT) | T212 | Uniprot |
P10636-8 (MAPT) | T231 | Uniprot |
P10636-8 (MAPT) | S235 | Uniprot |
P10636-8 (MAPT) | S404 | Uniprot |
P11171-2 (EPB41) | T60 | Uniprot |
P11171-2 (EPB41) | S679 | Uniprot |
P11387 (TOP1) | S112 | Uniprot |
P11387 (TOP1) | S394 | Uniprot |
P11388 (TOP2A) | S1213 | Uniprot |
P11388 (TOP2A) | S1247 | Uniprot |
P11388 (TOP2A) | S1354 | Uniprot |
P11388 (TOP2A) | S1361 | Uniprot |
P11388 (TOP2A) | S1393 | Uniprot |
P12270 (TPR) | S2073 | Uniprot |
P12272 (PTHLH) | T108 | Uniprot |
P12272 (PTHLH) | T121 | Uniprot |
P13051 (UNG) | S64 | Uniprot |
P14136-1 (GFAP) | S8 | Uniprot |
P14635 (CCNB1) | S126 | Uniprot |
P14635 (CCNB1) | S128 | Uniprot |
P15172 (MYOD1) | S5 | Uniprot |
P15172 (MYOD1) | S200 | Uniprot |
P15531 (NME1) | T94 | Uniprot |
P15531 (NME1) | S120 | Uniprot |
P15927 (RPA2) | S23 | Uniprot |
P15927 (RPA2) | S29 | Uniprot |
P15927 (RPA2) | S33 | Uniprot |
P16220 (CREB1) | S270 | Uniprot |
P16220 (CREB1) | S271 | Uniprot |
P16949 (STMN1) | S25 | Uniprot |
P16949-1 (STMN1) | S38 | Uniprot |
P17096 (HMGA1) | S36 | Uniprot |
P17096-2 (HMGA1) | T42 | Uniprot |
P17096 (HMGA1) | T53 | Uniprot |
P17096-2 (HMGA1) | T67 | Uniprot |
P17096 (HMGA1) | T78 | Uniprot |
P17302 (GJA1) | S255 | Uniprot |
P17661 (DES) | S32 | Uniprot |
P17676 (CEBPB) | S76 | Uniprot |
P17706-2 (PTPN2) | S304 | Uniprot |
P18031 (PTPN1) | S386 | Uniprot |
P18754-1 (RCC1) | S2 | Uniprot |
P18754 (RCC1) | S11 | Uniprot |
P18754 (RCC1) | T274 | Uniprot |
P18754 (RCC1) | S387 | Uniprot |
P18858 (LIG1) | S76 | Uniprot |
P19338 (NCL) | T121 | Uniprot |
P19338 (NCL) | T641 | Uniprot |
P19338 (NCL) | T707 | Uniprot |
P20338 (RAB4A) | S204 | Uniprot |
P20700 (LMNB1) | S23 | Uniprot |
P20700 (LMNB1) | S393 | Uniprot |
P21333 (FLNA) | S1084 | Uniprot |
P21333 (FLNA) | S1436 | Uniprot |
P21333 (FLNA) | S1459 | Uniprot |
P21333 (FLNA) | S1533 | Uniprot |
P21333 (FLNA) | S1630 | Uniprot |
P22234 (PAICS) | S27 | Uniprot |
P22314-1 (UBA1) | S4 | Uniprot |
P22314-1 (UBA1) | S835 | Uniprot |
P22392 (NME2) | T94 | Uniprot |
P23396 (RPS3) | T221 | Uniprot |
P23443 (RPS6KB1) | S394 | Uniprot |
P23443 (RPS6KB1) | S434 | Uniprot |
P23443 (RPS6KB1) | T444 | Uniprot |
P23443 (RPS6KB1) | S447 | Uniprot |
P23769 (GATA2) | T176 | Uniprot |
P24928 (POLR2A) | S1920 | Uniprot |
P24928 (POLR2A) | S1934 | Uniprot |
P25205 (MCM3) | S112 | Uniprot |
P26358 (DNMT1) | S154 | Uniprot |
P26368 (U2AF2) | S79 | Uniprot |
P27361-3 (MAPK3) | S343 | Uniprot |
P27816 (MAP4) | S696 | Uniprot |
P27816 (MAP4) | S787 | Uniprot |
P27816 (MAP4) | T892 | Uniprot |
P27816 (MAP4) | T901 | Uniprot |
P27816 (MAP4) | T917 | Uniprot |
P27824 (CANX) | S583 | Uniprot |
P29590 (PML) | S518 | Uniprot |
P29692 (EEF1D) | S133 | Uniprot |
P30101 (PDIA3) | S456 | Uniprot |
P30260 (CDC27) | T205 | Uniprot |
P30260 (CDC27) | T209 | Uniprot |
P30260 (CDC27) | S222 | Uniprot |
P30260 (CDC27) | T289 | Uniprot |
P30260 (CDC27) | S312 | Uniprot |
P30260 (CDC27) | T329 | Uniprot |
P30260 (CDC27) | T343 | Uniprot |
P30260 (CDC27) | S364 | Uniprot |
P30260 (CDC27) | S426 | Uniprot |
P30260 (CDC27) | T430 | Uniprot |
P30260 (CDC27) | S434 | Uniprot |
P30260 (CDC27) | S435 | Uniprot |
P30260 (CDC27) | T446 | Uniprot |
P30291 (WEE1) | S123 | Uniprot |
P30304 (CDC25A) | S18 | Uniprot |
P30304 (CDC25A) | S116 | Uniprot |
P30305-2 (CDC25B) | S146 | Uniprot |
P30305 (CDC25B) | S160 | Uniprot |
P30305-2 (CDC25B) | S307 | Uniprot |
P30305 (CDC25B) | S321 | Uniprot |
P30307 (CDC25C) | T48 | Uniprot |
P30307 (CDC25C) | T67 | Uniprot |
P30307-1 (CDC25C) | S122 | Uniprot |
P30307 (CDC25C) | T130 | Uniprot |
P30307 (CDC25C) | S168 | Uniprot |
P30307 (CDC25C) | S214 | Uniprot |
P31350-1 (RRM2) | S20 | Uniprot |
P31350 (RRM2) | T33 | Uniprot |
P31948 (STIP1) | T198 | Uniprot |
P31948 (STIP1) | T332 | Uniprot |
P33316-2 (DUT) | S11 | Uniprot |
P33316 (DUT) | S99 | Uniprot |
P33991 (MCM4) | T7 | Uniprot |
P33991 (MCM4) | T19 | Uniprot |
P33991 (MCM4) | S32 | Uniprot |
P33991 (MCM4) | S88 | Uniprot |
P33991 (MCM4) | T110 | Uniprot |
P33993 (MCM7) | S121 | Uniprot |
P35251 (RFC1) | T506 | Uniprot |
P35251 (RFC1) | S518 | Uniprot |
P35611 (ADD1) | S12 | Uniprot |
P35611 (ADD1) | S355 | Uniprot |
P36956 (SREBF1) | S439 | Uniprot |
P38398 (BRCA1) | S1189 | Uniprot |
P38398 (BRCA1) | S1191 | Uniprot |
P38398 (BRCA1) | S1497 | Uniprot |
P39748 (FEN1) | S187 | Uniprot |
P39880-1 (CUX1) | S1237 | Uniprot |
P39880 (CUX1) | S1270 | Uniprot |
P40763 (STAT3) | S727 | Uniprot |
P42166 (TMPO) | S424 | Uniprot |
P43307 (SSR1) | S268 | Uniprot |
P46013 (MKI67) | T761 | Uniprot |
P46013 (MKI67) | T1943 | Uniprot |
P46060 (RANGAP1) | T409 | Uniprot |
P46060 (RANGAP1) | S428 | Uniprot |
P46060 (RANGAP1) | S442 | Uniprot |
P46937 (YAP1) | T119 | Uniprot |
P46937 (YAP1) | S289 | Uniprot |
P46937 (YAP1) | S367 | Uniprot |
P47736-1 (RAP1GAP) | S484 | Uniprot |
P48200 (IREB2) | S157 | Uniprot |
P48681 (NES) | T315 | Uniprot |
P49418-1 (AMPH) | S272 | Uniprot |
P49418-1 (AMPH) | S276 | Uniprot |
P49418 (AMPH) | S285 | Uniprot |
P49450 (CENPA) | S68 | Uniprot |
P49459-2 (UBE2A) | S90 | Uniprot |
P49459 (UBE2A) | S120 | Uniprot |
P49715 (CEBPA) | S21 | Uniprot |
P49715 (CEBPA) | S234 | Uniprot |
P49792 (RANBP2) | T2153 | Uniprot |
P49792 (RANBP2) | S2246 | Uniprot |
P49792 (RANBP2) | S2251 | Uniprot |
P49792 (RANBP2) | S2276 | Uniprot |
P49792 (RANBP2) | S2280 | Uniprot |
P49915 (GMPS) | T318 | Uniprot |
P49916 (LIG3) | T191 | Uniprot |
P49916 (LIG3) | S210 | Uniprot |
P49916 (LIG3) | S913 | Uniprot |
P50570 (DNM2) | S764 | Uniprot |
P50570 (DNM2) | T766 | Uniprot |
P50613 (CDK7) | S164 | Uniprot |
P50613 (CDK7) | T170 | Uniprot |
P51587 (BRCA2) | S3291 | Uniprot |
P52732 (KIF11) | T926 | Uniprot |
P52926 (HMGA2) | S44 | Uniprot |
P52926 (HMGA2) | S59 | Uniprot |
P52948-2 (NUP98) | T529 | Uniprot |
P52948-2 (NUP98) | T536 | Uniprot |
P52948-2 (NUP98) | S595 | Uniprot |
P52948-2 (NUP98) | S606 | Uniprot |
P52948 (NUP98) | S612 | Uniprot |
P52948 (NUP98) | S623 | Uniprot |
P52948-2 (NUP98) | T653 | Uniprot |
P52948 (NUP98) | T670 | Uniprot |
P54132 (BLM) | S714 | Uniprot |
P54132 (BLM) | T766 | Uniprot |
P54274 (TERF1) | T344 | Uniprot |
P54274 (TERF1) | T371 | Uniprot |
P54578 (USP14) | T235 | Uniprot |
P55211 (CASP9) | T125 | Uniprot |
P61020-1 (RAB5B) | S123 | Uniprot |
P61978 (HNRNPK) | S216 | Uniprot |
P62136 (PPP1CA) | T320 | Uniprot |
P63279 (UBE2I) | S71 | Uniprot |
P67870 (CSNK2B) | S209 | Uniprot |
P68400-2 (CSNK2A1) | T208 | Uniprot |
P68400-2 (CSNK2A1) | T224 | Uniprot |
P68400-2 (CSNK2A1) | S226 | Uniprot |
P68400-2 (CSNK2A1) | S234 | Uniprot |
P68400 (CSNK2A1) | T344 | Uniprot |
P68400 (CSNK2A1) | T360 | Uniprot |
P68400 (CSNK2A1) | S362 | Uniprot |
P68400 (CSNK2A1) | S370 | Uniprot |
P82970 (HMGN5) | T31 | Uniprot |
Q01094 (E2F1) | S332 | Uniprot |
Q01094 (E2F1) | S337 | Uniprot |
Q01167 (FOXK2) | S373 | Uniprot |
Q01167 (FOXK2) | S428 | Uniprot |
Q01196 (RUNX1) | S21 | Uniprot |
Q01196 (RUNX1) | S249 | Uniprot |
Q01196 (RUNX1) | S266 | Uniprot |
Q01196 (RUNX1) | T273 | Uniprot |
Q01196-8 (RUNX1) | S276 | Uniprot |
Q01196-8 (RUNX1) | S293 | Uniprot |
Q01196-8 (RUNX1) | T300 | Uniprot |
Q01196-8 (RUNX1) | S303 | Uniprot |
Q01196 (RUNX1) | S397 | Uniprot |
Q01196-8 (RUNX1) | S424 | Uniprot |
Q01581 (HMGCS1) | S495 | Uniprot |
Q02539 (HIST1H1A) | T4 | Uniprot |
Q02750 (MAP2K1) | T286 | Uniprot |
Q02750 (MAP2K1) | T292 | Uniprot |
Q02880 (TOP2B) | S1424 | Uniprot |
Q02952 (AKAP12) | T767 | Uniprot |
Q03060-16 (CREM) | S87 | Uniprot |
Q03060-16 (CREM) | S110 | Uniprot |
Q03060-6 (CREM) | S136 | Uniprot |
Q04637 (EIF4G1) | S1231 | Uniprot |
Q05682-5 (CALD1) | T377 | Uniprot |
Q05682-4 (CALD1) | T383 | Uniprot |
Q05682-3 (CALD1) | T403 | Uniprot |
Q05682-6 (CALD1) | T409 | Uniprot |
Q05682-5 (CALD1) | S463 | Uniprot |
Q05682-4 (CALD1) | S469 | Uniprot |
Q05682-5 (CALD1) | T469 | Uniprot |
Q05682-4 (CALD1) | T475 | Uniprot |
Q05682-5 (CALD1) | S483 | Uniprot |
Q05682-3 (CALD1) | S489 | Uniprot |
Q05682-6 (CALD1) | S494 | Uniprot |
Q05682-3 (CALD1) | T495 | Uniprot |
Q05682-5 (CALD1) | S498 | Uniprot |
Q05682-6 (CALD1) | T500 | Uniprot |
Q05682-4 (CALD1) | S504 | Uniprot |
Q05682-3 (CALD1) | S509 | Uniprot |
Q05682-6 (CALD1) | S514 | Uniprot |
Q05682-3 (CALD1) | S524 | Uniprot |
Q05682-6 (CALD1) | S529 | Uniprot |
Q05682-1 (CALD1) | T638 | Uniprot |
Q05682-1 (CALD1) | S724 | Uniprot |
Q05682-1 (CALD1) | T730 | Uniprot |
Q05682-1 (CALD1) | S744 | Uniprot |
Q05682-1 (CALD1) | S759 | Uniprot |
Q06413 (MEF2C) | S396 | Uniprot |
Q06481 (APLP2) | T736 | Uniprot |
Q06830 (PRDX1) | T90 | Uniprot |
Q07666 (KHDRBS1) | T317 | Uniprot |
Q07820 (MCL1) | S64 | Uniprot |
Q07820 (MCL1) | T92 | Uniprot |
Q08050 (FOXM1) | S251 | Uniprot |
Q08050-2 (FOXM1) | T596 | Uniprot |
Q08050 (FOXM1) | T600 | Uniprot |
Q08050-1 (FOXM1) | T611 | Uniprot |
Q08050 (FOXM1) | T620 | Uniprot |
Q08050-3 (FOXM1) | T649 | Uniprot |
Q08379 (GOLGA2) | S37 | Uniprot |
Q09472 (EP300) | S1038 | Uniprot |
Q09472 (EP300) | S2039 | Uniprot |
Q09666 (AHNAK) | S5763 | Uniprot |
Q12778 (FOXO1) | S249 | Uniprot |
Q12888 (TP53BP1) | T1609 | Uniprot |
Q12888 (TP53BP1) | S1678 | Uniprot |
Q12959 (DLG1) | S158 | Uniprot |
Q12959 (DLG1) | S443 | Uniprot |
Q13042 (CDC16) | S112 | Uniprot |
Q13042 (CDC16) | S560 | Uniprot |
Q13042 (CDC16) | T581 | Uniprot |
Q13188 (STK3) | S385 | Uniprot |
Q13415 (ORC1) | S258 | Uniprot |
Q13415 (ORC1) | S273 | Uniprot |
Q13415 (ORC1) | T375 | Uniprot |
Q13428 (TCOF1) | S156 | Uniprot |
Q13428 (TCOF1) | S583 | Uniprot |
Q13428 (TCOF1) | T983 | Uniprot |
Q13501 (SQSTM1) | T269 | Uniprot |
Q13501 (SQSTM1) | S272 | Uniprot |
Q13535 (ATR) | S428 | Uniprot |
Q13541 (EIF4EBP1) | T37 | Uniprot |
Q13541 (EIF4EBP1) | T46 | Uniprot |
Q13541 (EIF4EBP1) | S65 | Uniprot |
Q13541 (EIF4EBP1) | T70 | Uniprot |
Q13541 (EIF4EBP1) | S83 | Uniprot |
Q13586 (STIM1) | S668 | Uniprot |
Q13950 (RUNX2) | S465 | Uniprot |
Q14005-3 (IL16) | T56 | Uniprot |
Q14005-1 (IL16) | T757 | Uniprot |
Q14157 (UBAP2L) | S454 | Uniprot |
Q14202 (ZMYM3) | T826 | Uniprot |
Q14203 (DCTN1) | S212 | Uniprot |
Q14244 (MAP7) | S209 | Uniprot |
Q14247 (CTTN) | S405 | Uniprot |
Q14493 (SLBP) | T62 | Uniprot |
Q14643 (ITPR1) | S421 | Uniprot |
Q14643 (ITPR1) | T800 | Uniprot |
Q14674 (ESPL1) | S1126 | Uniprot |
Q14739 (LBR) | S71 | Uniprot |
Q14739 (LBR) | S86 | Uniprot |
Q14790 (CASP8) | S387 | Uniprot |
Q14807 (KIF22) | S427 | Uniprot |
Q14807 (KIF22) | T463 | Uniprot |
Q14978 (NOLC1) | T607 | Uniprot |
Q14978 (NOLC1) | T610 | Uniprot |
Q14980 (NUMA1) | T2015 | Uniprot |
Q14980 (NUMA1) | T2055 | Uniprot |
Q14980 (NUMA1) | S2087 | Uniprot |
Q14980 (NUMA1) | T2106 | Uniprot |
Q14C86 (GAPVD1) | S950 | Uniprot |
Q14CS0 (UBXN2B) | S56 | Uniprot |
Q14CS0 (UBXN2B) | T59 | Uniprot |
Q15149-7 (PLEC) | T4370 | Uniprot |
Q15149-8 (PLEC) | T4380 | Uniprot |
Q15149-9 (PLEC) | T4388 | Uniprot |
Q15149-5 (PLEC) | T4402 | Uniprot |
Q15149-6 (PLEC) | T4406 | Uniprot |
Q15149 (PLEC) | T4539 | Uniprot |
Q15398 (DLGAP5) | T329 | Uniprot |
Q15398 (DLGAP5) | S618 | Uniprot |
Q15398 (DLGAP5) | T639 | Uniprot |
Q15398 (DLGAP5) | S839 | Uniprot |
Q15717 (ELAVL1) | S202 | Uniprot |
Q15910 (EZH2) | T345 | Uniprot |
Q15910 (EZH2) | T487 | Uniprot |
Q16513 (PKN2) | S535 | Uniprot |
Q16659 (MAPK6) | S684 | Uniprot |
Q16659 (MAPK6) | S688 | Uniprot |
Q16659 (MAPK6) | T698 | Uniprot |
Q16659 (MAPK6) | S705 | Uniprot |
Q16665 (HIF1A) | S668 | Uniprot |
Q2M2I8 (AAK1) | T389 | Uniprot |
Q2NKX8 (ERCC6L) | T1063 | Uniprot |
Q38SD2 (LRRK1) | T1427 | Uniprot |
Q53EZ4 (CEP55) | S425 | Uniprot |
Q53EZ4 (CEP55) | S428 | Uniprot |
Q5BJF6-3 (ODF2) | S796 | Uniprot |
Q5FBB7 (SGO1) | T346 | Uniprot |
Q6PGQ7 (BORA) | S252 | Uniprot |
Q6Y7W6-3 (GIGYF2) | S30 | Uniprot |
Q7Z3J3 (RGPD4) | S1276 | Uniprot |
Q86WB0 (ZC3HC1) | S395 | Uniprot |
Q8IWB6 (TEX14) | T618 | Uniprot |
Q8IWB6 (TEX14) | T727 | Uniprot |
Q8IWB6 (TEX14) | T728 | Uniprot |
Q8IX03 (WWC1) | S542 | Uniprot |
Q8IX03 (WWC1) | S931 | Uniprot |
Q8IXJ6 (SIRT2) | S368 | Uniprot |
Q8IZD2 (KMT2E) | T912 | Uniprot |
Q8IZP0 (ABI1) | S216 | Uniprot |
Q8N122 (RPTOR) | S696 | Uniprot |
Q8N122 (RPTOR) | T706 | Uniprot |
Q8NEB9 (PIK3C3) | T159 | Uniprot |
Q8NFH8-2 (REPS2) | S411 | Uniprot |
Q8NFH8 (REPS2) | S463 | Uniprot |
Q8NHV4 (NEDD1) | T550 | Uniprot |
Q8TAP9 (MPLKIP) | S93 | Uniprot |
Q8TAP9 (MPLKIP) | S104 | Uniprot |
Q8TAP9 (MPLKIP) | T120 | Uniprot |
Q8TEM1-1 (NUP210) | S1881 | Uniprot |
Q8TF76 (HASPIN) | T128 | Uniprot |
Q8WWK9 (CKAP2) | T623 | Uniprot |
Q8WX93 (PALLD) | S641 | Uniprot |
Q8WX93 (PALLD) | S766 | Uniprot |
Q92574 (TSC1) | T417 | Uniprot |
Q92574-1 (TSC1) | S584 | Uniprot |
Q92574 (TSC1) | T1047 | Uniprot |
Q92934 (BAD) | S91 | Uniprot |
Q92993 (KAT5) | S86 | Uniprot |
Q92993 (KAT5) | S90 | Uniprot |
Q92993-3 (KAT5) | S119 | Uniprot |
Q92993-3 (KAT5) | S123 | Uniprot |
Q93045-1 (STMN2) | S73 | Uniprot |
Q96C19 (EFHD2) | S74 | Uniprot |
Q96C36 (PYCR2) | S304 | Uniprot |
Q96EB6 (SIRT1) | T530 | Uniprot |
Q96EB6 (SIRT1) | S540 | Uniprot |
Q96FF9 (CDCA5) | S21 | Uniprot |
Q96FF9 (CDCA5) | S33 | Uniprot |
Q96FF9 (CDCA5) | T48 | Uniprot |
Q96FF9 (CDCA5) | S75 | Uniprot |
Q96FF9 (CDCA5) | S79 | Uniprot |
Q96FF9 (CDCA5) | S83 | Uniprot |
Q96FF9 (CDCA5) | T111 | Uniprot |
Q96FF9 (CDCA5) | T115 | Uniprot |
Q96FF9 (CDCA5) | S126 | Uniprot |
Q96FF9 (CDCA5) | S139 | Uniprot |
Q96FF9 (CDCA5) | T151 | Uniprot |
Q96FF9 (CDCA5) | T159 | Uniprot |
Q96FF9 (CDCA5) | S164 | Uniprot |
Q96FF9 (CDCA5) | S181 | Uniprot |
Q96FF9 (CDCA5) | S209 | Uniprot |
Q96JH7 (VCPIP1) | T761 | Uniprot |
Q96JH7 (VCPIP1) | S768 | Uniprot |
Q96KB5 (PBK) | T9 | Uniprot |
Q96Q89-3 (KIF20B) | T1604 | Uniprot |
Q96Q89 (KIF20B) | T1644 | Uniprot |
Q96R06 (SPAG5) | S135 | Uniprot |
Q96R06 (SPAG5) | S249 | Uniprot |
Q96RL1 (UIMC1) | S677 | Uniprot |
Q96T23 (RSF1) | S1375 | Uniprot |
Q96T88 (UHRF1) | S639 | Uniprot |
Q99638 (RAD9A) | S277 | Uniprot |
Q99638 (RAD9A) | T292 | Uniprot |
Q99638 (RAD9A) | S328 | Uniprot |
Q99638 (RAD9A) | S336 | Uniprot |
Q99638 (RAD9A) | T355 | Uniprot |
Q99661 (KIF2C) | T537 | Uniprot |
Q99666 (RGPD6) | S1275 | Uniprot |
Q99728 (BARD1) | S148 | Uniprot |
Q99728 (BARD1) | S251 | Uniprot |
Q99728 (BARD1) | S288 | Uniprot |
Q99728 (BARD1) | T299 | Uniprot |
Q9BPX3 (NCAPG) | T308 | Uniprot |
Q9BPX3 (NCAPG) | T332 | Uniprot |
Q9BPX3 (NCAPG) | T931 | Uniprot |
Q9BXS6 (NUSAP1) | T300 | Uniprot |
Q9BXS6 (NUSAP1) | T338 | Uniprot |
Q9BYG3 (NIFK) | T238 | Uniprot |
Q9GZM8 (NDEL1) | T219 | Uniprot |
Q9GZM8 (NDEL1) | S242 | Uniprot |
Q9GZM8 (NDEL1) | T245 | Uniprot |
Q9GZV5 (WWTR1) | S90 | Uniprot |
Q9GZV5 (WWTR1) | S105 | Uniprot |
Q9GZV5 (WWTR1) | T285 | Uniprot |
Q9GZV5 (WWTR1) | T326 | Uniprot |
Q9GZV5 (WWTR1) | T346 | Uniprot |
Q9H0H5 (RACGAP1) | T588 | Uniprot |
Q9H1A4 (ANAPC1) | T291 | Uniprot |
Q9H1A4 (ANAPC1) | S355 | Uniprot |
Q9H1A4 (ANAPC1) | S373 | Uniprot |
Q9H1A4 (ANAPC1) | S377 | Uniprot |
Q9H1A4 (ANAPC1) | T530 | Uniprot |
Q9H1A4 (ANAPC1) | T537 | Uniprot |
Q9H1A4 (ANAPC1) | S547 | Uniprot |
Q9H1A4 (ANAPC1) | S555 | Uniprot |
Q9H1A4 (ANAPC1) | S688 | Uniprot |
Q9H1A4 (ANAPC1) | T701 | Uniprot |
Q9H1E3 (NUCKS1) | S181 | Uniprot |
Q9H467 (CUEDC2) | S110 | Uniprot |
Q9H4X1-1 (RGCC) | T111 | Uniprot |
Q9H8V3 (ECT2) | T373 | Uniprot |
Q9H8V3 (ECT2) | T444 | Uniprot |
Q9H8V3-4 (ECT2) | T815 | Uniprot |
Q9H8V3 (ECT2) | T846 | Uniprot |
Q9H9S0 (NANOG) | S71 | Uniprot |
Q9HCH0 (NCKAP5L) | S436 | Uniprot |
Q9HCH0 (NCKAP5L) | S447 | Uniprot |
Q9HCH0 (NCKAP5L) | S466 | Uniprot |
Q9HCH0 (NCKAP5L) | S473 | Uniprot |
Q9HCH0 (NCKAP5L) | S567 | Uniprot |
Q9HCH0 (NCKAP5L) | S573 | Uniprot |
Q9HCH0 (NCKAP5L) | S763 | Uniprot |
Q9NQR1 (KMT5A) | S100 | Uniprot |
Q9NQS7 (INCENP) | T59 | Uniprot |
Q9NQS7 (INCENP) | T412 | Uniprot |
Q9NQX3 (GPHN) | S270 | Uniprot |
Q9NTG7 (SIRT3) | T150 | Uniprot |
Q9NTG7 (SIRT3) | S159 | Uniprot |
Q9NTI5 (PDS5B) | T1370 | Uniprot |
Q9NXR1-2 (NDE1) | T215 | Uniprot |
Q9NXR1-2 (NDE1) | S239 | Uniprot |
Q9NXR1 (NDE1) | T246 | Uniprot |
Q9NZH5 (PTTG2) | S165 | Uniprot |
Q9NZJ0 (DTL) | T464 | Uniprot |
Q9NZT2 (OGFR) | S378 | Uniprot |
Q9UBF8 (PI4KB) | S266 | Uniprot |
Q9UHD8-2 (SEPT9) | T24 | Uniprot |
Q9UJ70 (NAGK) | S76 | Uniprot |
Q9UJX2 (CDC23) | T562 | Uniprot |
Q9UJX2 (CDC23) | T565 | Uniprot |
Q9UJX5 (ANAPC4) | S779 | Uniprot |
Q9UK53-2 (ING1) | S126 | Uniprot |
Q9UKX7 (NUP50) | S221 | Uniprot |
Q9ULC4 (MCTS1) | S118 | Uniprot |
Q9ULW0 (TPX2) | T72 | Uniprot |
Q9ULW0 (TPX2) | S738 | Uniprot |
Q9UNZ2-1 (NSFL1C) | S140 | Uniprot |
Q9UPP1 (PHF8) | S69 | Uniprot |
Q9UPP1 (PHF8) | S120 | Uniprot |
Q9UQ35 (SRRM2) | T866 | Uniprot |
Q9UQ35 (SRRM2) | T1413 | Uniprot |
Q9UQR0 (SCML2) | T305 | Uniprot |
Q9UQR0 (SCML2) | S511 | Uniprot |
Q9UQR0 (SCML2) | S590 | Uniprot |
Q9Y2I6 (NINL) | S185 | Uniprot |
Q9Y2I6 (NINL) | S589 | Uniprot |
Q9Y2V2 (CARHSP1) | T23 | Uniprot |
Q9Y3Z3 (SAMHD1) | T592 | Uniprot |
Q9Y4H2 (IRS2) | S391 | Uniprot |
Q9Y5N6 (ORC6) | T195 | Uniprot |
Q9Y5T5 (USP16) | S552 | Uniprot |
Q9Y6I3-3 (EPN1) | S357 | Uniprot |
Q9Y6I3 (EPN1) | S382 | Uniprot |
Q9Y6Q9 (NCOA3) | S728 | Uniprot |
Q9Y6Q9 (NCOA3) | S867 | Uniprot |
研究背景
Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, GOLGA2/GM130, GRASP1, UBE2A/hHR6A, HIST1H1 proteins/histone H1, HMGA1, HIVEP3/KRC, LMNA, LMNB, LMNC, LBR, LATS1, MAP1B, MAP4, MARCKS, MCM2, MCM4, MKLP1, MYB, NEFH, NFIC, NPC/nuclear pore complex, PITPNM1/NIR2, NPM1, NCL, NUCKS1, NPM1/numatrin, ORC1, PRKAR2A, EEF1E1/p18, EIF3F/p47, p53/TP53, NONO/p54NRB, PAPOLA, PLEC/plectin, RB1, TPPP, UL40/R2, RAB4A, RAP1GAP, RCC1, RPS6KB1/S6K1, KHDRBS1/SAM68, ESPL1, SKI, BIRC5/survivin, STIP1, TEX14, beta-tubulins, MAPT/TAU, NEDD1, VIM/vimentin, TK1, FOXO1, RUNX1/AML1, SAMHD1, SIRT2 and RUNX2. CDK1/CDC2-cyclin-B controls pronuclear union in interphase fertilized eggs. Essential for early stages of embryonic development. During G2 and early mitosis, CDC25A/B/C-mediated dephosphorylation activates CDK1/cyclin complexes which phosphorylate several substrates that trigger at least centrosome separation, Golgi dynamics, nuclear envelope breakdown and chromosome condensation. Once chromosomes are condensed and aligned at the metaphase plate, CDK1 activity is switched off by WEE1- and PKMYT1-mediated phosphorylation to allow sister chromatid separation, chromosome decondensation, reformation of the nuclear envelope and cytokinesis. Inactivated by PKR/EIF2AK2- and WEE1-mediated phosphorylation upon DNA damage to stop cell cycle and genome replication at the G2 checkpoint thus facilitating DNA repair. Reactivated after successful DNA repair through WIP1-dependent signaling leading to CDC25A/B/C-mediated dephosphorylation and restoring cell cycle progression. In proliferating cells, CDK1-mediated FOXO1 phosphorylation at the G2-M phase represses FOXO1 interaction with 14-3-3 proteins and thereby promotes FOXO1 nuclear accumulation and transcription factor activity, leading to cell death of postmitotic neurons. The phosphorylation of beta-tubulins regulates microtubule dynamics during mitosis. NEDD1 phosphorylation promotes PLK1-mediated NEDD1 phosphorylation and subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation. In addition, CC2D1A phosphorylation regulates CC2D1A spindle pole localization and association with SCC1/RAD21 and centriole cohesion during mitosis. The phosphorylation of Bcl-xL/BCL2L1 after prolongated G2 arrest upon DNA damage triggers apoptosis. In contrast, CASP8 phosphorylation during mitosis prevents its activation by proteolysis and subsequent apoptosis. This phosphorylation occurs in cancer cell lines, as well as in primary breast tissues and lymphocytes. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. CALD1 phosphorylation promotes Schwann cell migration during peripheral nerve regeneration. CDK1-cyclin-B complex phosphorylates NCKAP5L and mediates its dissociation from centrosomes during mitosis. Regulates the amplitude of the cyclic expression of the core clock gene ARNTL/BMAL1 by phosphorylating its transcriptional repressor NR1D1, and this phosphorylation is necessary for SCF(FBXW7)-mediated ubiquitination and proteasomal degradation of NR1D1.
(Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry.
Phosphorylation at Thr-161 by CAK/CDK7 activates kinase activity. Phosphorylation at Thr-14 and Tyr-15 by PKMYT1 prevents nuclear translocation. Phosphorylation at Tyr-15 by WEE1 and WEE2 inhibits the protein kinase activity and acts as a negative regulator of entry into mitosis (G2 to M transition). Phosphorylation by PKMYT1 and WEE1 takes place during mitosis to keep CDK1-cyclin-B complexes inactive until the end of G2. By the end of G2, PKMYT1 and WEE1 are inactivated, but CDC25A and CDC25B are activated. Dephosphorylation by active CDC25A and CDC25B at Thr-14 and Tyr-15, leads to CDK1 activation at the G2-M transition. Phosphorylation at Tyr-15 by WEE2 during oogenesis is required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, leading to prevent meiotic reentry. Phosphorylation by WEE2 is also required for metaphase II exit during egg activation to ensure exit from meiosis in oocytes and promote pronuclear formation. Phosphorylated at Tyr-4 by PKR/EIF2AK2 upon genotoxic stress. This phosphorylation triggers CDK1 polyubiquitination and subsequent proteolysis, thus leading to G2 arrest. In response to UV irradiation, phosphorylation at Tyr-15 by PRKCD activates the G2/M DNA damage checkpoint.
Polyubiquitinated upon genotoxic stress.
Nucleus. Cytoplasm. Mitochondrion. Cytoplasm>Cytoskeleton>Microtubule organizing center>Centrosome. Cytoplasm>Cytoskeleton>Spindle.
Note: Cytoplasmic during the interphase. Colocalizes with SIRT2 on centrosome during prophase and on splindle fibers during metaphase of the mitotic cell cycle. Reversibly translocated from cytoplasm to nucleus when phosphorylated before G2-M transition when associated with cyclin-B1. Accumulates in mitochondria in G2-arrested cells upon DNA-damage.
Isoform 2 is found in breast cancer tissues.
Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin. Interacts with cyclins-B (CCNB1, CCNB2 and CCNB3) to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. Can also form CDK1-cylin-D and CDK1-cyclin-E complexes that phosphorylate RB1 in vitro. Binds to RB1 and other transcription factors such as FOXO1 and RUNX2. Promotes G2-M transition when in complex with a cyclin-B. Interacts with DLGAP5. Binds to the CDK inhibitors CDKN1A/p21 and CDKN1B/p27. Isoform 2 is unable to complex with cyclin-B1 and also fails to bind to CDKN1A/p21. Interacts with catalytically active CCNB1 and RALBP1 during mitosis to form an endocytotic complex during interphase. Associates with cyclins-A and B1 during S-phase in regenerating hepatocytes. Interacts with FANCC. Interacts with CEP63; this interaction recruits CDK1 to centrosomes. Interacts with CENPA. Interacts with NR1D1. Interacts with proteasome subunit PSMA8; to participate in meiosis progression during spermatogenesis (By similarity).
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
研究领域
· Cellular Processes > Cell growth and death > Cell cycle. (View pathway)
· Cellular Processes > Cell growth and death > Oocyte meiosis. (View pathway)
· Cellular Processes > Cell growth and death > p53 signaling pathway. (View pathway)
· Cellular Processes > Cell growth and death > Cellular senescence. (View pathway)
· Cellular Processes > Cellular community - eukaryotes > Gap junction. (View pathway)
· Human Diseases > Infectious diseases: Viral > Herpes simplex infection.
· Human Diseases > Infectious diseases: Viral > Epstein-Barr virus infection.
· Human Diseases > Cancers: Overview > Viral carcinogenesis.
· Organismal Systems > Endocrine system > Progesterone-mediated oocyte maturation.
文献引用
Application: WB Species: Human Sample: HeyA8 cells
限制条款
产品的规格、报价、验证数据请以官网为准,官网链接:www.affbiotech.com | www.affbiotech.cn(简体中文)| www.affbiotech.jp(日本語)产品的数据信息为Affinity所有,未经授权不得收集Affinity官网数据或资料用于商业用途,对抄袭产品数据的行为我们将保留诉诸法律的权利。
产品相关数据会因产品批次、产品检测情况随时调整,如您已订购该产品,请以订购时随货说明书为准,否则请以官网内容为准,官网内容有改动时恕不另行通知。
Affinity保证所销售产品均经过严格质量检测。如您购买的商品在规定时间内出现问题需要售后时,请您在Affinity官方渠道提交售后申请。产品仅供科学研究使用。不用于诊断和治疗。
产品未经授权不得转售。
Affinity Biosciences将不会对在使用我们的产品时可能发生的专利侵权或其他侵权行为负责。Affinity Biosciences, Affinity Biosciences标志和所有其他商标所有权归Affinity Biosciences LTD.