产品: PRPS1 抗体
货号: AF7030
描述: Rabbit polyclonal antibody to PRPS1
应用: WB
反应: Human, Mouse, Rat
预测: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
分子量: 34 KD; 35kD(Calculated).
蛋白号: P60891
RRID: AB_2843470

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 50ul RMB¥ 1250 现货
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 200ul RMB¥ 3000 现货

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:1000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
预测:
Pig(78%), Bovine(78%), Horse(78%), Sheep(78%), Rabbit(63%), Dog(0%), Chicken(67%), Xenopus(57%)
克隆:
Polyclonal
特异性:
PRPS1 Antibody detects endogenous levels of total PRPS1.
RRID:
AB_2843470
引用格式: Affinity Biosciences Cat# AF7030, RRID:AB_2843470.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

ARTS; CMTX5; Deafness 2 perceptive congenital; Deafness X linked 2 perceptive congenital; DFN2; DFNX1; EC 2.7.6.1; KIAA0967; Phosphoribosyl pyrophosphate synthase I; Phosphoribosyl pyrophosphate synthetase I; PPRibP; Prps1; PRPS1_HUMAN; PRS I; PRS-I; PRSI; Ribose phosphate pyrophosphokinase I; Ribose-phosphate pyrophosphokinase 1;

抗原和靶标

免疫原:
Uniprot:
基因/基因ID:
描述:
Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
序列:
MPNIKIFSGSSHQDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDNLMELLIMINACKIASASRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIRENISEWRNCTIVSPDAGGAKRVTSIADRLNVDFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAGATRVYAILTHGIFSGPAISRINNACFEAVVVTNTIPQEDKMKHCSKIQVIDISMILAEAIRRTHNGESVSYLFSHVPL

种属预测

种属预测:

score>80的预测可信度较高,可尝试用于WB检测。*预测模型主要基于免疫原序列比对,结果仅作参考,不作为质保凭据。

Species
Results
Score
Pig
78
Horse
78
Bovine
78
Sheep
78
Chicken
67
Rabbit
63
Xenopus
57
Dog
0
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - P60891 作为底物

Site PTM Type Enzyme
K5 Ubiquitination
K18 Ubiquitination
R22 Methylation
K29 Ubiquitination
S36 Phosphorylation
S103 Phosphorylation
Y146 Phosphorylation
R156 Methylation
K176 Acetylation
K176 Ubiquitination
S180 Phosphorylation
R184 Methylation
K194 Acetylation
K194 Ubiquitination
R204 Methylation
K212 Acetylation
K212 Ubiquitination
T225 Phosphorylation
T228 Phosphorylation
K235 Ubiquitination
S238 Phosphorylation
T242 Phosphorylation
Y245 Phosphorylation
K280 Ubiquitination
S308 Phosphorylation
S310 Phosphorylation
Y311 Phosphorylation

研究背景

功能:

Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.

亚基结构:

Homodimer. The active form is probably a hexamer composed of 3 homodimers.

蛋白家族:

Belongs to the ribose-phosphate pyrophosphokinase family.

研究领域

· Metabolism > Carbohydrate metabolism > Pentose phosphate pathway.

· Metabolism > Nucleotide metabolism > Purine metabolism.

· Metabolism > Global and overview maps > Metabolic pathways.

· Metabolism > Global and overview maps > Carbon metabolism.

· Metabolism > Global and overview maps > Biosynthesis of amino acids.

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