| 产品: | Septin 1 抗体 |
| 货号: | AF9196 |
| 描述: | Rabbit polyclonal antibody to Septin 1 |
| 应用: | WB IF/ICC |
| 反应: | Human |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit |
| 分子量: | 41kDa; 42kD(Calculated). |
| 蛋白号: | Q8WYJ6 |
| RRID: | AB_2843386 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# AF9196, RRID:AB_2843386.
展开/折叠
DIFF6; Differentiation 6 (deoxyguanosine triphosphate triphosphohydrolase); LARP; MGC20394; Peanut like protein 3; Peanut-like protein 3; PNUTL3; SEP1; SEPT1; SEPT1_HUMAN; Septin 1; Septin-1; Serologically defined breast cancer antigen NY BR 24; Serologically defined breast cancer antigen NY-BR-24;
抗原和靶标
- Q8WYJ6 SEPT1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDKEYVGFAALPNQLHRKSVKKGFDFTLMVAGESGLGKSTLINSLFLTNLYEDRQVPEASARLTQTLAIERRGVEIEEGGVKVKLTLVDTPGFGDSVDCSDCWLPVVKFIEEQFEQYLRDESGLNRKNIQDSRVHCCLYFISPFGRGLRPLDVAFLRAVHEKVNIIPVIGKADALMPQETQALKQKIRDQLKEEEIHIYQFPECDSDEDEDFKRQDAEMKESIPFAVVGSCEVVRDGGNRPVRGRRYSWGTVEVENPHHCDFLNLRRMLVQTHLQDLKEVTHDLLYEGYRARCLQSLARPGARDRASRSKLSRQSATEIPLPMLPLADTEKLIREKDEELRRMQEMLEKMQAQMQQSQAQGEQSDAL
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q8WYJ6 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K3 | Ubiquitination | Uniprot | |
| Y5 | Phosphorylation | Uniprot | |
| K18 | Ubiquitination | Uniprot | |
| S19 | Phosphorylation | Uniprot | |
| K22 | Ubiquitination | Uniprot | |
| T48 | Phosphorylation | Uniprot | |
| Y51 | Phosphorylation | Uniprot | |
| S60 | Phosphorylation | Uniprot | |
| K82 | Ubiquitination | Uniprot | |
| K84 | Ubiquitination | Uniprot | |
| K127 | Ubiquitination | Uniprot | |
| S132 | Phosphorylation | Uniprot | |
| K162 | Ubiquitination | Uniprot | |
| K171 | Ubiquitination | Uniprot | |
| K184 | Ubiquitination | Uniprot | |
| K186 | Ubiquitination | Uniprot | |
| Y199 | Phosphorylation | Uniprot | |
| S206 | Phosphorylation | Uniprot | |
| K213 | Ubiquitination | Uniprot | |
| K220 | Ubiquitination | Uniprot | |
| R240 | Methylation | Uniprot | |
| Y247 | Phosphorylation | Uniprot | |
| S248 | Phosphorylation | Q96GD4 (AURKB) | Uniprot |
| T251 | Phosphorylation | Uniprot | |
| K278 | Ubiquitination | Uniprot | |
| Y286 | Phosphorylation | Uniprot | |
| Y289 | Phosphorylation | Uniprot | |
| S307 | Phosphorylation | Q96GD4 (AURKB) | Uniprot |
| S315 | Phosphorylation | Q96GD4 (AURKB) | Uniprot |
| T317 | Phosphorylation | Uniprot | |
| K331 | Ubiquitination | Uniprot | |
| K336 | Ubiquitination | Uniprot | |
| K349 | Ubiquitination | Uniprot |
研究背景
Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential).
Cytoplasm. Cytoplasm>Cytoskeleton. Cytoplasm>Cytoskeleton>Microtubule organizing center>Centrosome. Midbody.
Note: Remains at the centrosomes and the nearby microtubules throughout mitosis. Localizes to the midbody during cytokinesis.
Expressed at high levels in lymphoid and hematopoietic tissues.
Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By similarity). Interacts with AURKB.
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
研究领域
· Human Diseases > Infectious diseases: Bacterial > Bacterial invasion of epithelial cells.
限制条款
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