SERP1 Antibody - #DF9873

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产品: SERP1 抗体
货号: DF9873
描述: Rabbit polyclonal antibody to SERP1
应用: WB IHC IF/ICC
文献验证: WB
反应: Human, Mouse, Rat
预测: Pig, Bovine, Rabbit, Chicken
分子量: 7 kDa; 7kD(Calculated).
蛋白号: Q9Y6X1
RRID: AB_2843067

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   规格 价格 库存
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MS Report
HPLC Report
MSDS
说明书
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实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:1000-3000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
预测:
Pig(100%), Bovine(%), Rabbit(%), Chicken(%)
克隆:
Polyclonal
特异性:
SERP1 Antibody detects endogenous levels of total SERP1.
RRID:
AB_2843067
引用格式: Affinity Biosciences Cat# DF9873, RRID:AB_2843067.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

D3Ucla1; Ramp4; Ribosome associated membrane protein 4; Ribosome attached membrane protein 4; Ribosome-attached membrane protein 4; Serp1; SERP1_HUMAN; Stress associated endoplasmic reticulum protein 1; Stress-associated endoplasmic reticulum protein 1;

抗原和靶标

免疫原:
Uniprot:

Q9Y6X1(SERP1_HUMAN) >>Visit HPA database.

基因/基因ID:
SERP1(27230)
序列:
MVAKQRIRMANEKHSKNITQRGNVAKTSRNAPEEKASVGPWLLALFIFVVCGSAIFQIIQSIRMGM

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Pig
100
Bovine
100
Rabbit
100
Chicken
92
Xenopus
67
Zebrafish
67
Horse
0
Sheep
0
Dog
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

研究背景

功能:

Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target proteins after termination of ER stress. May modulate the use of N-glycosylation sites on target proteins (By similarity).

细胞定位:

Membrane>Single-pass type IV membrane protein. Endoplasmic reticulum membrane>Single-pass membrane protein>Cytoplasmic side.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
亚基结构:

Interacts with SEC61B, SEC61A1 and the SEC61 complex. Interacts with CANX (By similarity).

蛋白家族:

Belongs to the RAMP4 family.

文献引用

1). SERP1 reduces inchoate acute hepatic injury through regulation of endoplasmic reticulum stress via the GSK3β/β‑catenin/TCF/LEF signaling pathway. Molecular Medicine Reports, 2022 (PubMed: 35419615) [IF=3.4]

Application: WB    Species: Mouse    Sample:

Figure 1. - Establishment of an inchoate acute hepatic injury model and detection of ERS-related proteins. (A) Pathological changes of tissues of mice in the model group detected by H&E staining. (B) Levels of alanine aminotransferase and aspartate aminotransferase in the serum. (C) ERS-related protein expression detected by western blotting. SERP1 expression in acute hepatic injury tissues detected by (D) immunohistochemistry and (E) western blotting. (F) SERP1 expression in acute hepatic injury cells detected by western blotting and reverse transcription-quantitative PCR. *P

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