产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF9865, RRID:AB_2843059.
展开/折叠
Alpha Pix; Alpha-Pix; ARHG6_HUMAN; ARHGEF6; COOL 2; COOL-2; COOL2; Mental retardation, X linked 46; MRX46; PAK interacting exchange factor alpha; PAK-interacting exchange factor alpha; PIXA; Rac/Cdc42 guanine exchange factor (GEF) 6; Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6; Rac/Cdc42 guanine nucleotide exchange factor 6; Rho guanine nucleotide exchange factor 6;
抗原和靶标
- Q15052 ARHG6_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MNPEEQIVTWLISLGVLESPKKTICDPEEFLKSSLKNGVVLCKLINRLMPGSVEKFCLDPQTEADCINNINDFLKGCATLQVEIFDPDDLYSGVNFSKVLSTLLAVNKATEDQLSERPCGRSSSLSAANTSQTNPQGAVSSTVSGLQRQSKTVEMTENGSHQLIVKARFNFKQTNEDELSVCKGDIIYVTRVEEGGWWEGTLNGRTGWFPSNYVREIKSSERPLSPKAVKGFETAPLTKNYYTVVLQNILDTEKEYAKELQSLLVTYLRPLQSNNNLSTVEVTSLLGNFEEVCTFQQTLCQALEECSKFPENQHKVGGCLLSLMPHFKSMYLAYCANHPSAVNVLTQHSDELEQFMENQGASSPGILILTTNLSKPFMRLEKYVTLLQELERHMEDTHPDHQDILKAIVAFKTLMGQCQDLRKRKQLELQILSEPIQAWEGEDIKNLGNVIFMSQVMVQYGACEEKEERYLMLFSNVLIMLSASPRMSGFIYQGKIPIAGTVVTRLDEIEGNDCTFEITGNTVERIVVHCNNNQDFQEWLEQLNRLIRGPASCSSLSKTSSSSCSAHSSFSSTGQPRGPLEPPQIIKPWSLSCLRPAPPLRPSAALGYKERMSYILKESSKSPKTMKKFLHKRKTERKPSEEEYVIRKSTAALEEDAQILKVIEAYCTSANFQQGHGSSTRKDSIPQVLLPEEEKLIIEETRSNGQTIMEEKSLVDTVYALKDEVRELKQENKRMKQCLEEELKSRRDLEKLVRRLLKQTDECIRGESSSKTSILP
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q15052 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K22 | Ubiquitination | Uniprot | |
| K32 | Ubiquitination | Uniprot | |
| K43 | Ubiquitination | Uniprot | |
| Y91 | Phosphorylation | Uniprot | |
| S101 | Phosphorylation | Uniprot | |
| K108 | Ubiquitination | Uniprot | |
| S122 | Phosphorylation | Uniprot | |
| S123 | Phosphorylation | Uniprot | |
| S124 | Phosphorylation | Uniprot | |
| S126 | Phosphorylation | Uniprot | |
| S131 | Phosphorylation | Uniprot | |
| T133 | Phosphorylation | Uniprot | |
| S144 | Phosphorylation | Uniprot | |
| S150 | Phosphorylation | Uniprot | |
| K151 | Ubiquitination | Uniprot | |
| K166 | Ubiquitination | Uniprot | |
| Y188 | Phosphorylation | Uniprot | |
| S225 | Phosphorylation | Q04759 (PRKCQ) | Uniprot |
| K227 | Ubiquitination | Uniprot | |
| K230 | Ubiquitination | Uniprot | |
| K254 | Ubiquitination | Uniprot | |
| K382 | Ubiquitination | Uniprot | |
| K406 | Ubiquitination | Uniprot | |
| K412 | Ubiquitination | Uniprot | |
| Y470 | Phosphorylation | Uniprot | |
| S488 | Phosphorylation | Q04759 (PRKCQ) | Uniprot |
| Y492 | Phosphorylation | Uniprot | |
| K495 | Ubiquitination | Uniprot | |
| T504 | Phosphorylation | Uniprot | |
| S552 | Phosphorylation | Uniprot | |
| K558 | Ubiquitination | Uniprot | |
| S561 | Phosphorylation | Uniprot | |
| S562 | Phosphorylation | Uniprot | |
| S565 | Phosphorylation | Uniprot | |
| S569 | Phosphorylation | Uniprot | |
| T573 | Phosphorylation | Uniprot | |
| S592 | Phosphorylation | Uniprot | |
| Y608 | Phosphorylation | Uniprot | |
| S613 | Phosphorylation | Uniprot | |
| Y614 | Phosphorylation | Uniprot | |
| K617 | Ubiquitination | Uniprot | |
| S622 | Phosphorylation | Uniprot | |
| K627 | Acetylation | Uniprot | |
| T635 | Phosphorylation | Uniprot | |
| K638 | Ubiquitination | Uniprot | |
| S640 | Phosphorylation | Uniprot | |
| Y644 | Phosphorylation | Uniprot | |
| K648 | Ubiquitination | Uniprot | |
| S649 | Phosphorylation | Uniprot | |
| T650 | Phosphorylation | Uniprot | |
| K661 | Ubiquitination | Uniprot | |
| Y666 | Phosphorylation | Uniprot | |
| S669 | Phosphorylation | Uniprot | |
| K682 | Ubiquitination | Uniprot | |
| S684 | Phosphorylation | P17612 (PRKACA) , Q13976 (PRKG1) | Uniprot |
| K695 | Ubiquitination | Uniprot | |
| T701 | Phosphorylation | Uniprot | |
| S703 | Phosphorylation | Uniprot | |
| K712 | Ubiquitination | Uniprot | |
| S713 | Phosphorylation | Uniprot | |
| T717 | Phosphorylation | Uniprot | |
| Y719 | Phosphorylation | Uniprot | |
| K722 | Ubiquitination | Uniprot | |
| K736 | Ubiquitination | Uniprot | |
| K751 | Acetylation | Uniprot | |
| K758 | Ubiquitination | Uniprot |
研究背景
Acts as a RAC1 guanine nucleotide exchange factor (GEF).
Cell projection>Lamellipodium.
Ubiquitous.
Interacts with PAK kinases through the SH3 domain. Interacts with GIT1. Component of cytoplasmic complexes, which also contain PXN, GIT1 and PAK1 (By similarity). Interacts with PARVB. Interacts with BIN2. Identified in a complex with BIN2 and GIT2.
研究领域
· Cellular Processes > Cell motility > Regulation of actin cytoskeleton. (View pathway)
· Human Diseases > Cancers: Specific types > Pancreatic cancer. (View pathway)
限制条款
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