| 产品: | RAB43 抗体 |
| 货号: | DF9833 |
| 描述: | Rabbit polyclonal antibody to RAB43 |
| 应用: | WB IHC |
| 反应: | Human, Mouse |
| 预测: | Pig, Horse |
| 分子量: | 23 kDa; 23kD(Calculated). |
| 蛋白号: | Q86YS6 |
| RRID: | AB_2843027 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF9833, RRID:AB_2843027.
展开/折叠
RAB41; RAB43; RAB43_HUMAN; Ras related protein Rab 41; Ras related protein Rab 43; Ras-related protein Rab-41; Ras-related protein Rab-43;
抗原和靶标
Widely expressed in brain, testis, lung, heart, ovary, colon, kidney, uterus and spleen but not in liver.
- Q86YS6 RAB43_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAGPGPGPGDPDEQYDFLFKLVLVGDASVGKTCVVQRFKTGAFSERQGSTIGVDFTMKTLEIQGKRVKLQIWDTAGQERFRTITQSYYRSANGAILAYDITKRSSFLSVPHWIEDVRKYAGSNIVQLLIGNKSDLSELREVSLAEAQSLAEHYDILCAIETSAKDSSNVEEAFLRVATELIMRHGGPLFSEKSPDHIQLNSKDIGEGWGCGC
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
研究背景
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The low intrinsic GTPase activity of RAB43 is activated by USP6NL. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for the structural integrity of the Golgi complex. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.
Cytoplasmic vesicle>Phagosome. Cytoplasmic vesicle>Phagosome membrane>Lipid-anchor>Cytoplasmic side. Golgi apparatus. Golgi apparatus>trans-Golgi network membrane>Lipid-anchor. Golgi apparatus>trans-Golgi network.
Note: Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211).
Widely expressed in brain, testis, lung, heart, ovary, colon, kidney, uterus and spleen but not in liver.
Interacts with GDI1, GDI2, CHM and CHML; phosphorylation at Thr-82 disrupts these interactions.
Belongs to the small GTPase superfamily. Rab family.
限制条款
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