| 产品: | RAB39B 抗体 |
| 货号: | DF9829 |
| 描述: | Rabbit polyclonal antibody to RAB39B |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 25 kDa,37kDa; 25kD(Calculated). |
| 蛋白号: | Q96DA2 |
| RRID: | AB_2843023 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF9829, RRID:AB_2843023.
展开/折叠
6330580M05Rik; MRX72; OTTHUMP00000024247; OTTMUSP00000020441; RAB39B, member RAS oncogene family; Ras related protein Rab 39B; RAS-associated protein RAB39B; RP13-228J13.2; RP23-252K7.1;
抗原和靶标
- Q96DA2 RB39B_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEAIWLYQFRLIVIGDSTVGKSCLIRRFTEGRFAQVSDPTVGVDFFSRLVEIEPGKRIKLQIWDTAGQERFRSITRAYYRNSVGGLLLFDITNRRSFQNVHEWLEETKVHVQPYQIVFVLVGHKCDLDTQRQVTRHEAEKLAAAYGMKYIETSARDAINVEKAFTDLTRDIYELVKRGEITIQEGWEGVKSGFVPNVVHSSEEVVKSERRCLC
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
研究背景
Small GTPases Rab involved in autophagy. The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. May regulate the homeostasis of SNCA/alpha-synuclein. Together with PICK1 proposed to ensure selectively GRIA2 exit from the endoplasmic reticulum to the Golgi and to regulate AMPAR compostion at the post-synapses and thus synaptic transmission (By similarity).
Cell membrane>Lipid-anchor>Cytoplasmic side. Cytoplasmic vesicle membrane>Lipid-anchor>Cytoplasmic side. Golgi apparatus.
Note: Partial colocalization with markers that cycle from the cell surface to the trans-Golgi network.
Highly expressed in the brain.
Interacts (in GTP-bound form) with PICK1 (via PDZ domain); a PICK1 homodimer may allow simultaneous association of RAB39B and GRIA2 to PICK1 which is involved in GRIA2 trafficking.
Belongs to the small GTPase superfamily. Rab family.
限制条款
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