产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF9795, RRID:AB_2842989.
展开/折叠
FLJ22524; FLJ22622; HGNC:30265; MGC78448; No Rab11 binding protein 1A; NOEL1A; Rab coupling protein; Rab effector protein; Rab interacting recycling protein; Rab-coupling protein; RAB11 family interacting protein 1 (class I); Rab11 family interacting protein 1D; Rab11 family-interacting protein 1; Rab11 FIP1; Rab11-FIP1; RAB11FIP1; RCP; RFIP1_HUMAN;
抗原和靶标
Isoform 2 is expressed in brain, heart, testis, lung, spleen, ovary and small intestine.
- Q6WKZ4 RFIP1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSLMVSAGRGLGAVWSPTHVQVTVLQARGLRAKGPGGTSDAYAVIQVGKEKYATSVSERSLGAPVWREEATFELPSLLSSGPAAAATLQLTVLHRALLGLDKFLGRAEVDLRDLHRDQGRRKTQWYKLKSKPGKKDKERGEIEVDIQFMRNNMTASMFDLSMKDKSRNPFGKLKDKIKGKNKDSGSDTASAIIPSTTPSVDSDDESVVKDKKKKSKIKTLLSKSNLQKTPLSQSMSVLPTSKPEKVLLRPGDFQSQWDEDDNEDESSSASDVMSHKRTASTDLKQLNQVNFTLPKKEGLSFLGGLRSKNDVLSRSNVCINGNHVYLEQPEAKGEIKDSSPSSSPSPKGFRKKHLFSSTENLAAGSWKEPAEGGGLSSDRQLSESSTKDSLKSMTLPSYRPAPLVSGDLRENMAPANSEATKEAKESKKPESRRSSLLSLMTGKKDVAKGSEGENPLTVPGREKEGMLMGVKPGEDASGPAEDLVRRSEKDTAAVVSRQGSSLNLFEDVQITEPEAEPESKSEPRPPISSPRAPQTRAVKPRLEVSPEAQPTARLPSPTDSPSSLPPLPSSSGQASVPSELGHGADTQSSESPSVFSSLSSPIAAPISTSTPIESWPLVDRGQAKSEGPPLLPKAELQTESLTPVPNSGSSALGSLFKQPSFPANKGTEDSLMGRTRETGTEKNTSSLELEESLPEQPETGRQEEELPRFPCKKQDYSPSSGEAQEVPFALSLSSDGAVSPVGELAAGGDRDLESQAGSLVESKARDAAEEVAPPLPMGASVPSIDSMMRKLEEMGLNLRKDQKKTKKRVSFSEQLFTEEAVAGAALLVEGHSSCPQELNPAWSVAGNASDGEPPESPHAEDSERESVTTPGPATCGAPASPADHLLLPSQEESFSEVPMSEASSAKDTPLFRMEGEDALVTQYQSKASDHEGLLSDPLSDLQLVSDFKSPIMADLNLSLPSIPEVASDDERIDQVEDDGDQVEDDGETAKSSTLDIGALSLGLVVPCPERGKGPSGEADRLVLGEGLCDFRLQAPQASVTAPSEQTTEFGIHKPHLGKSSSLDKQLPGPSGGEEEKPMGNGSPSPPPGTSLDNPVPSPSPSEIFPVTHSFPSSAHSDTHHTSTAESQKKATAEGSAGRVENFGKRKPLLQAWVSPSETHPVSAQPGAGTGSAKHRLHPVKPMNAMATKVANCSLGTATIISENLNNEVMMKKYSPSDPAFAYAQLTHDELIQLVLKQKETISKKEFQVRELEDYIDNLLVRVMEETPNILRIPTQVGKKAGKM
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q6WKZ4 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| R9 | Methylation | Uniprot | |
| K129 | Acetylation | Uniprot | |
| K131 | Acetylation | Uniprot | |
| T154 | Phosphorylation | Uniprot | |
| S156 | Phosphorylation | Uniprot | |
| S161 | Phosphorylation | Uniprot | |
| S184 | Phosphorylation | Uniprot | |
| T188 | Phosphorylation | Uniprot | |
| S190 | Phosphorylation | Uniprot | |
| T197 | Phosphorylation | Uniprot | |
| S199 | Phosphorylation | Uniprot | |
| S202 | Phosphorylation | Uniprot | |
| S206 | Phosphorylation | Uniprot | |
| K218 | Ubiquitination | Uniprot | |
| T219 | Phosphorylation | Uniprot | |
| S222 | Phosphorylation | Uniprot | |
| S224 | Phosphorylation | Uniprot | |
| T229 | Phosphorylation | Uniprot | |
| S232 | Phosphorylation | Uniprot | |
| S234 | Phosphorylation | Uniprot | |
| S236 | Phosphorylation | Uniprot | |
| S241 | Phosphorylation | Uniprot | |
| S266 | Phosphorylation | Uniprot | |
| S268 | Phosphorylation | Uniprot | |
| T278 | Phosphorylation | Uniprot | |
| S280 | Phosphorylation | Uniprot | |
| T281 | Phosphorylation | Uniprot | |
| T292 | Phosphorylation | Uniprot | |
| K296 | Ubiquitination | Uniprot | |
| S300 | Phosphorylation | Uniprot | |
| S307 | Phosphorylation | Uniprot | |
| S315 | Phosphorylation | Uniprot | |
| Y325 | Phosphorylation | Uniprot | |
| S338 | Phosphorylation | Uniprot | |
| S339 | Phosphorylation | Uniprot | |
| S341 | Phosphorylation | Uniprot | |
| S342 | Phosphorylation | Uniprot | |
| S343 | Phosphorylation | Uniprot | |
| S345 | Phosphorylation | Uniprot | |
| K352 | Ubiquitination | Uniprot | |
| S356 | Phosphorylation | Uniprot | |
| S357 | Phosphorylation | Uniprot | |
| T358 | Phosphorylation | Uniprot | |
| S365 | Phosphorylation | Uniprot | |
| S382 | Phosphorylation | Uniprot | |
| S384 | Phosphorylation | Uniprot | |
| T386 | Phosphorylation | Uniprot | |
| K387 | Ubiquitination | Uniprot | |
| S389 | Phosphorylation | Uniprot | |
| K391 | Ubiquitination | Uniprot | |
| S392 | Phosphorylation | Uniprot | |
| T394 | Phosphorylation | Uniprot | |
| S397 | Phosphorylation | Uniprot | |
| Y398 | Phosphorylation | Uniprot | |
| S431 | Phosphorylation | Uniprot | |
| S434 | Phosphorylation | Uniprot | |
| S435 | Phosphorylation | Uniprot | |
| S438 | Phosphorylation | Uniprot | |
| T441 | Phosphorylation | Uniprot | |
| K443 | Acetylation | Uniprot | |
| K448 | Ubiquitination | Uniprot | |
| S450 | Phosphorylation | Uniprot | |
| S477 | Phosphorylation | Uniprot | |
| S487 | Phosphorylation | Uniprot | |
| T491 | Phosphorylation | Uniprot | |
| S496 | Phosphorylation | Uniprot | |
| S500 | Phosphorylation | Uniprot | |
| S501 | Phosphorylation | Uniprot | |
| T511 | Phosphorylation | Uniprot | |
| S519 | Phosphorylation | Uniprot | |
| S521 | Phosphorylation | Uniprot | |
| S528 | Phosphorylation | Uniprot | |
| S529 | Phosphorylation | Uniprot | |
| S545 | Phosphorylation | Uniprot | |
| S625 | Phosphorylation | Uniprot | |
| T642 | Phosphorylation | Uniprot | |
| S660 | Phosphorylation | Uniprot | |
| S670 | Phosphorylation | Uniprot | |
| T684 | Phosphorylation | Uniprot | |
| S685 | Phosphorylation | Uniprot | |
| S686 | Phosphorylation | Uniprot | |
| S692 | Phosphorylation | Uniprot | |
| S739 | Phosphorylation | Uniprot | |
| S754 | Phosphorylation | Uniprot | |
| S758 | Phosphorylation | Uniprot | |
| K800 | Acetylation | Uniprot | |
| K803 | Acetylation | Uniprot | |
| S880 | Phosphorylation | Uniprot | |
| S925 | Phosphorylation | Uniprot | |
| S928 | Phosphorylation | Uniprot | |
| S935 | Phosphorylation | Uniprot | |
| S967 | Phosphorylation | Uniprot | |
| S1135 | Phosphorylation | Uniprot | |
| S1154 | Phosphorylation | Uniprot | |
| T1187 | Phosphorylation | Uniprot | |
| S1193 | Phosphorylation | Uniprot | |
| T1196 | Phosphorylation | Uniprot | |
| K1211 | Ubiquitination | Uniprot | |
| K1212 | Ubiquitination | Uniprot | |
| S1214 | Phosphorylation | Uniprot | |
| S1216 | Phosphorylation | Uniprot | |
| T1226 | Phosphorylation | Uniprot | |
| Y1254 | Phosphorylation | Uniprot | |
| T1274 | Phosphorylation | Uniprot | |
| K1278 | Ubiquitination | Uniprot |
研究背景
A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis.
Recycling endosome.
Note: Rab11A rather than Rab4A mediates localization in the endocytic recycling compartment (ERC).
Cytoplasmic vesicle>Phagosome membrane.
Note: Membrane-bound (isoform 2). Colocalizes with Rab11A at phagosomes (isoform 2).
Isoform 2 is expressed in brain, heart, testis, lung, spleen, ovary and small intestine.
Homooligomer (isoform 2). Isoform 2 interacts with RAB4A, RAB11A, RAB11B and RAB25. According to RAB4A binding to RAB11FIP1 is of very low affinity in vitro and in vivo.
研究领域
· Cellular Processes > Transport and catabolism > Endocytosis. (View pathway)
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