| 产品: | MRAP 抗体 |
| 货号: | DF9621 |
| 描述: | Rabbit polyclonal antibody to MRAP |
| 应用: | WB IHC |
| 反应: | Human, Mouse |
| 分子量: | 19 kDa; 19kD(Calculated). |
| 蛋白号: | Q8TCY5 |
| RRID: | AB_2842817 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF9621, RRID:AB_2842817.
展开/折叠
B27; C21orf61; FALP; Fat cell-specific low molecular weight protein; Fat tissue-specific low MW protein; FGD2; GCCD2; Melanocortin-2 receptor accessory protein; Mrap; MRAP_HUMAN;
抗原和靶标
Expressed in adrenal cortex, testis, breast, thyroid, lymph node, ovary and fat. Expressed in adipose tissues.
- Q8TCY5 MRAP_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MANGTNASAPYYSYEYYLDYLDLIPVDEKKLKAHKHSIVIAFWVSLAAFVVLLFLILLYMSWSASPQMRNSPKHHQTCPWSHGLNLHLCIQKCLPCHREPLATSQAQASSVEPGSRTGPDQPLRQESSSTLPLGGFQTHPTLLWELTLNGGPLVRSKPSEPPPGDRTSQLQS
研究背景
Modulator of melanocortin receptors (MC1R, MC2R, MC3R, MC4R and MC5R). Acts by increasing ligand-sensitivity of melanocortin receptors and enhancing generation of cAMP by the receptors. Required both for MC2R trafficking to the cell surface of adrenal cells and for signaling in response to corticotropin (ACTH). May be involved in the intracellular trafficking pathways in adipocyte cells.
Cell membrane>Single-pass membrane protein. Endoplasmic reticulum membrane>Single-pass membrane protein.
Note: The formation of antiparallel homo- and heterodimers suggest that N- and C-terminus can both localize in the cytoplasmic and extracellular parts, depending on the context (PubMed:20371771). Upon insulin stimulation, it is redistributed into spotty structures throughout the cytoplasm.
Expressed in adrenal cortex, testis, breast, thyroid, lymph node, ovary and fat. Expressed in adipose tissues.
Homodimer and heterodimer. Forms antiparallel homodimers and heterodimers with MRAP2. Interacts with MC1R, MC2R, MC3R, MC4R and MC5R.
Belongs to the MRAP family.
限制条款
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