Phospho-Lyn (Tyr508) Antibody - #AF3119

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产品: 磷酸化 Lyn (Tyr508) 抗体
货号: AF3119
描述: Rabbit polyclonal antibody to Phospho-Lyn (Tyr508)
应用: WB IHC IF/ICC
文献验证: WB
反应: Human, Mouse, Rat
预测: Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
蛋白号: P07948
RRID: AB_2834554

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 50ul RMB¥ 1300 现货
 100ul RMB¥ 2400 现货
 200ul RMB¥ 3200 现货

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说明书
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实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
Phospho-Lyn (Tyr508) Antibody detects endogenous levels of Lyn only when phosphorylated at Tyrosine 507.
RRID:
AB_2834554
引用格式: Affinity Biosciences Cat# AF3119, RRID:AB_2834554.
偶联:
Unconjugated.
纯化:
The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

AA407514; EC 2.7.10.2; FLJ26625; Hck 2; JTK 8; JTK8; Lck/Yes related novel protein tyrosine kinase; LYN; LYN proto oncogene, Src family tyrosine kinase; LYN_HUMAN; ONCOGENE LYN; p53Lyn; p56Lyn; Tyrosine protein kinase LYN; Tyrosine-protein kinase Lyn; V yes 1 Yamaguchi sarcoma viral related oncogene homolog; Yamaguchi sarcoma viral (v yes 1) related oncogene homolog;

抗原和靶标

免疫原:

A synthesized peptide derived from human Lyn around the phosphorylation site of Tyr507.

基因/基因ID:
LYN(4067)
描述:
Lyn a tyrosine kinase of the Src family that plays a role in B cell antigen-receptor signaling.

研究领域

· Environmental Information Processing > Signal transduction > NF-kappa B signaling pathway.   (View pathway)

· Human Diseases > Infectious diseases: Bacterial > Epithelial cell signaling in Helicobacter pylori infection.

· Human Diseases > Infectious diseases: Viral > Epstein-Barr virus infection.

· Human Diseases > Cancers: Overview > Viral carcinogenesis.

· Organismal Systems > Immune system > Chemokine signaling pathway.   (View pathway)

· Organismal Systems > Immune system > Platelet activation.   (View pathway)

· Organismal Systems > Immune system > B cell receptor signaling pathway.   (View pathway)

· Organismal Systems > Immune system > Fc epsilon RI signaling pathway.   (View pathway)

· Organismal Systems > Immune system > Fc gamma R-mediated phagocytosis.   (View pathway)

· Organismal Systems > Nervous system > Long-term depression.

文献引用

1). DNA-Engineered Modular Nanovaccines Featuring Precise Topology for Enhanced Immunogenicity. Advanced materials (Deerfield Beach, Fla.), 2025 (PubMed: 40371439) [IF=27.4]
2). Anti-allergic actions of a Chinese patent medicine, huoxiangzhengqi oral liquid, in RBL-2H3 cells and in mice. Pharmaceutical Biology, 2021 (PubMed: 34078224) [IF=3.9]

Application: WB    Species: Mouse    Sample: RBL-2H3 cells

Figure 5. Inhibitory effects of HXZQ-OL on the phosphorylation of FceRI-induced degranulation signalling cascades (A, B, C) and MAPKs (D) in IgE/Ag-mediated RBL- 2H3 cells. IgE-sensitized RBL-2H3 cells were incubated with HXZQ-OL for 30min, followed by DNP-BSA challenge for 10min. The expression levels of p-Fyn, p-Lyn, p- Syk, p-PLCc1, p-PLCc2, p-PKCd, p-Gabs, p-PI3K, p-Akt, p-ERK1/2, p-p38 and p-JNK1/2 were normalized to total proteins, respectively. The data were expressed as the mean±SD values of three independent experiments. ? p<0.05 and ?? p<0.01.

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