F13B Antibody - #DF9401

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产品: F13B 抗体
货号: DF9401
描述: Rabbit polyclonal antibody to F13B
应用: WB IHC IF/ICC
反应: Human, Monkey
预测: Pig, Zebrafish, Bovine, Sheep, Rabbit, Dog
分子量: 76kDa; 76kD(Calculated).
蛋白号: P05160
RRID: AB_2842597

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   规格 价格 库存
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
IHC 1:50-1:200, IF/ICC 1:100-1:500, WB 1:1000-3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Monkey
预测:
Pig(100%), Zebrafish(83%), Bovine(86%), Sheep(100%), Rabbit(86%), Dog(100%)
克隆:
Polyclonal
特异性:
F13B Antibody detects endogenous levels of total F13B.
RRID:
AB_2842597
引用格式: Affinity Biosciences Cat# DF9401, RRID:AB_2842597.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Coagulation factor XIII, A2 polypeptide; Coagulation factor XIII, B polypeptide; F13A2; F13B; FXIIIB;

抗原和靶标

免疫原:
Uniprot:

P05160(F13B_HUMAN) >>Visit HPA database.

基因/基因ID:
F13B(2165)
序列:
MRLKNLTFIIILIISGELYAEEKPCGFPHVENGRIAQYYYTFKSFYFPMSIDKKLSFFCLAGYTTESGRQEEQTTCTTEGWSPEPRCFKKCTKPDLSNGYISDVKLLYKIQENMRYGCASGYKTTGGKDEEVVQCLSDGWSSQPTCRKEHETCLAPELYNGNYSTTQKTFKVKDKVQYECATGYYTAGGKKTEEVECLTYGWSLTPKCTKLKCSSLRLIENGYFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQCYNFGWYPESPVCEGRRNRCPPPPLPINSKIQTHSTTYRHGEIVHIECELNFEIHGSAEIRCEDGKWTEPPKCIEGQEKVACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITCNRGKWTLPPECVENNENCKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRCEQGKWSSPPVCLEPCTVNVDYMNRNNIEMKWKYEGKVLHGDLIDFVCKQGYDLSPLTPLSELSVQCNRGEVKYPLCTRKESKGMCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYCLDGMWTTPPLCLEPCTLSFTEMEKNNLLLKWDFDNRPHILHGEYIEFICRGDTYPAELYITGSILRMQCDRGQLKYPRCIPRQSTLSYQEPLRT

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Pig
100
Sheep
100
Dog
100
Bovine
86
Rabbit
86
Zebrafish
83
Horse
71
Chicken
50
Xenopus
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - P05160 作为底物

Site PTM Type Enzyme
N162 N-Glycosylation
T182 Phosphorylation
S373 Phosphorylation
Y512 Phosphorylation
N545 N-Glycosylation
Y643 Phosphorylation
T661 Phosphorylation

研究背景

功能:

The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin.

细胞定位:

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
亚基结构:

Tetramer of two A chains (F13A1) and two B (F13B) chains.

研究领域

· Organismal Systems > Immune system > Complement and coagulation cascades.   (View pathway)

文献引用

1). Cationic Zinc is Required for Factor XII Recruitment and Activation by Stimulated Platelets and for Thrombus Formation in vivo. JOURNAL OF THROMBOSIS AND HAEMOSTASIS (PubMed: 32542960) [IF=10.4]

Application: IF/ICC    Species: Mouse    Sample:

FIGURE 5 Factor XII deficiency inhibits thrombus formation in vivo. A, Wild-type (WT) or FXII knockout mice (FXII KO) mice underwent quantitative assessment of thrombus formation in the cremaster arteriole laser injury model (platelet accumulation in red, fibrin formation in green). Representative intravital images are shown, together with median curves and area under the curve (AUC) distributions for platelet accumulation (B-C) and fibrin formation (D-E).

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