CLDN18 Antibody - #DF9392
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| 产品: | CLDN18 抗体 |
| 货号: | DF9392 |
| 描述: | Rabbit polyclonal antibody to CLDN18 |
| 应用: | WB IHC |
| 反应: | Human, Mouse, Rat, Monkey |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit |
| 分子量: | 28 kDa; 28kD(Calculated). |
| 蛋白号: | P56856 |
| RRID: | AB_2842588 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF9392, RRID:AB_2842588.
展开/折叠
Claudin 18; Claudin-18; CLD18_HUMAN; CLDN18; SFTA5; SFTPJ;
抗原和靶标
Isoform A1: Expression is restricted to the lung (PubMed:19047087). Isoform A2: Expression is restricted to the stomach mucosa where it is predominantly observed in the epithelial cells of the pit region and the base of the gastric glands including exocrine and endocrine cells (at protein level) (PubMed:19047087).
- P56856 CLD18_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSTTTCQVVAFLLSILGLAGCIAATGMDMWSTQDLYDNPVTSVFQYEGLWRSCVRQSSGFTECRPYFTILGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTLTSGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGWVAGGLTLIGGVMMCIACRGLAPEETNYKAVSYHASGHSVAYKPGGFKASTGFGSNTKNKKIYDGGARTEDEVQSYPSKHDYV
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P56856 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y206 | Phosphorylation | Uniprot | |
| S210 | Phosphorylation | Uniprot | |
| Y211 | Phosphorylation | Uniprot | |
| S214 | Phosphorylation | Uniprot | |
| S217 | Phosphorylation | Uniprot | |
| Y220 | Phosphorylation | Uniprot | |
| T229 | Phosphorylation | Uniprot | |
| Y241 | Phosphorylation | Uniprot | |
| T247 | Phosphorylation | Uniprot | |
| S253 | Phosphorylation | Uniprot | |
| Y254 | Phosphorylation | Uniprot | |
| S256 | Phosphorylation | Uniprot | |
| Y260 | Phosphorylation | Uniprot |
研究背景
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Cell junction>Tight junction. Cell membrane>Multi-pass membrane protein.
Note: Localizes to tight junctions in epithelial cells.
Isoform A1: Expression is restricted to the lung. Isoform A2: Expression is restricted to the stomach mucosa where it is predominantly observed in the epithelial cells of the pit region and the base of the gastric glands including exocrine and endocrine cells (at protein level).
Belongs to the claudin family.
研究领域
· Cellular Processes > Cellular community - eukaryotes > Tight junction. (View pathway)
· Environmental Information Processing > Signaling molecules and interaction > Cell adhesion molecules (CAMs). (View pathway)
· Human Diseases > Infectious diseases: Viral > Hepatitis C.
· Organismal Systems > Immune system > Leukocyte transendothelial migration. (View pathway)
文献引用
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