PDE2A Antibody - #DF9370
| 产品: | PDE2A 抗体 |
| 货号: | DF9370 |
| 描述: | Rabbit polyclonal antibody to PDE2A |
| 应用: | WB |
| 反应: | Human, Mouse, Rat |
| 预测: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 106 kDa; 106kD(Calculated). |
| 蛋白号: | O00408 |
| RRID: | AB_2842566 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF9370, RRID:AB_2842566.
展开/折叠
5''-cyclic phosphodiesterase; cGMP dependent 3'5' cyclic phosphodiesterase; cGMP stimulated phosphodiesterase 1; cGMP stimulated phosphodiesterase 4; cGMP-dependent 3''; cGMP-stimulated phosphodiesterase 2; CGS PDE; CGS-PDE; cGSPDE; Cyclic GMP stimulated phosphodiesterase; Cyclic GMP-stimulated phosphodiesterase; Human cGMP stimulated 3'5' cyclic nucleotide phosphodiesterase; PDE 2A; PDE 2A1; PDE 2A4; PDE2A; PDE2A_HUMAN; PDE2A1; PDE2A4; phosphodiesterase 2A; Phosphodiesterase 2A cGMP stimulated;
抗原和靶标
Expressed in brain and to a lesser extent in heart, placenta, lung, skeletal muscle, kidney and pancreas.
- O00408 PDE2A_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGQACGHSILCRSQQYPAARPAEPRGQQVFLKPDEPPPPPQPCADSLQDALLSLGSVIDISGLQRAVKEALSAVLPRVETVYTYLLDGESQLVCEDPPHELPQEGKVREAIISQKRLGCNGLGFSDLPGKPLARLVAPLAPDTQVLVMPLADKEAGAVAAVILVHCGQLSDNEEWSLQAVEKHTLVALRRVQVLQQRGPREAPRAVQNPPEGTAEDQKGGAAYTDRDRKILQLCGELYDLDASSLQLKVLQYLQQETRASRCCLLLVSEDNLQLSCKVIGDKVLGEEVSFPLTGCLGQVVEDKKSIQLKDLTSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFLDEEYEVPDLDGTRAPINGCCSLDAE
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - O00408 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| G2 | Myristoylation | Uniprot | |
| S13 | Phosphorylation | Uniprot | |
| S125 | Phosphorylation | Uniprot | |
| T213 | Phosphorylation | Uniprot | |
| K508 | Ubiquitination | Uniprot | |
| K523 | Ubiquitination | Uniprot | |
| Y573 | Phosphorylation | Uniprot | |
| Y582 | Phosphorylation | Uniprot | |
| K584 | Ubiquitination | Uniprot | |
| K712 | Ubiquitination | Uniprot | |
| Y754 | Phosphorylation | Uniprot | |
| Y854 | Phosphorylation | Uniprot | |
| Y871 | Phosphorylation | Uniprot | |
| K880 | Ubiquitination | Uniprot | |
| S912 | Phosphorylation | Uniprot | |
| Y920 | Phosphorylation | Uniprot |
研究背景
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Plays an important role in growth and invasion of malignant melanoma cells (e.g. pseudomyxoma peritonei (PMP) cell line).
Regulates mitochondrial cAMP levels and respiration (By similarity). Involved in the regulation of mitochondria morphology/dynamics and apoptotic cell death via local modulation of cAMP/PKA signaling in the mitochondrion, including the monitoring of local cAMP levels at the outer mitochondrial membrane and of PKA-dependent phosphorylation of DNM1L.
Cell membrane>Lipid-anchor.
Mitochondrion matrix. Mitochondrion inner membrane. Mitochondrion outer membrane.
Cytoplasm.
Mitochondrion.
Expressed in brain and to a lesser extent in heart, placenta, lung, skeletal muscle, kidney and pancreas.
Homodimer.
GAF 1 functions as a dimerization domain, whereas GAF 2 binds cGMP, which causes activation of the catalytic activity of the enzyme.
Belongs to the cyclic nucleotide phosphodiesterase family. PDE2 subfamily.
研究领域
· Environmental Information Processing > Signal transduction > cGMP-PKG signaling pathway. (View pathway)
· Human Diseases > Substance dependence > Morphine addiction.
· Metabolism > Nucleotide metabolism > Purine metabolism.
· Organismal Systems > Sensory system > Olfactory transduction.
· Organismal Systems > Endocrine system > Aldosterone synthesis and secretion.
限制条款
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